Impact of environmental factors and physical activity on disability and quality of life in CIDP

Abstract

A few observational studies and randomized trials suggest that exercise and rehabilitation may improve activity limitation and quality of life (QoL) in patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), but the impact of other modifiable factors on the severity of the disease is not well understood. Using a structured questionnaire, we collected data on lifestyle and dietary habits of the patients included in the Italian CIDP database to investigate the possible influence of modifiable lifestyle factors on disability and QoL. Questionnaire data were available for 323 patients. The effect of lifestyle and dietary exposures on impairment, disability and QoL was evaluated using logistic regression models, adjusting for age, sex, disease duration, physical activity and smoking. Physical activity was associated with lower sensory impairment by the ISS scale, less disability by the INCAT and RODS scale and a better QoL in all the domains of EURO-QoL scale with the exception of anxiety/depression. None of the other parameters had an impact on these scales. This study adds evidence to the possible role of physical activity in improving symptom severity, disability and QoL in patients with CIDP. None of the other environmental factors investigated appeared to have an impact on the severity and health perception of CIDP.

Comprehensive approaches for diagnosis, monitoring and treatment of chronic inflammatory demyelinating polyneuropathy

“…In real life the influence of these factors is under discussion. In a study with 323 CIDP patients physical activity improves symptom severity, disability and quality of life, but other environmental factors as smoking, alcohol and different dietary regimes did not have an impact on the severity and health perception of CIDP [98].…”

“…The data on the influence of nutrition and environmental factors in CIDP are scarce. Several studies have shown an association of diet and environmental factors like tobacco and alcohol consumption with the progression of disability in different autoimmune diseases [98,99]. In neuroinflammatory and neurodegenerative diseases, the immunological influence of the gut microbiome has increasingly gotten into focus of research [100].…”

Clinical characteristics in a cohort of patients with chronic inflammatory demyelinating polyneuropathy: a retrospective study

“…Furthermore, a study in Mexico found that diabetes is the main associated comorbidity.7 In our study, diabetes was present in 27.8% of the patients, similar to other cohorts (20%, 30.4%, and 18%) [14][15][16] . Other associated factors have been studied: diet, smoking, alcohol consumption, fatigue, toxic exposure, and disability progression and quality of life [17][18][19] .…”

Quality of Life of People With Motor Disabilities, Involved or Not in Parasports

“…The positive effects of physical exercise are well documented in the literature, especially for PWD. Doneddu et al (2020) found that strength training reduces nerve lesions in patients with chronic in ammatory demyelinating polyradiculoneuropathy, due to muscle ber hypertrophy, the antiin ammatory effect of exercise or an increase in neural impulse.…”