The study discusses the use of oxygenated fuels in reduction of exhaust emissions from diesel engines. The study analyzes the physicochemical properties of oxygenated compounds in diesel fuels based on which 12 such compounds were selected for experimental research (glycol ethers, maleates, carbonates and alcohols). The study presents the results of investigations of the influence of oxygenated fuels on the exhaust emissions under dynamic homologation cycle chassis dynamometer conditions (diesel passenger vehicle, NEDC and FTP-75 cycles). The relationship among the content of individual oxygenated compounds, the conditions of the tests cycle and the exhaust emissions has been ascertained. The performed studies and experimental research have shown that the application of oxygenated fuels in diesel engines results in a significant reduction of the PM emission at a small increase in the emission of NO x. Changes in the emission of CO and HC depend not only on the oxygen content in the fuel but also on the self-ignition quality of the applied oxygenated compounds. The application of oxygenated fuels does not influence the emission of CO 2. Out of the analyzed oxygenated compounds, the most advantageous emission changes (reduction of the emission of PM, CO and HC at a small increase in the emission of NO x) are generated by the compounds of the glycol ethers group.