Impact of edaphic factors and nutrient management on the hepatoprotective efficiency of Carlinoside purified from pigeon pea leaves: An evaluation of UGT1A1 activity in hepatitis induced organelles

Das, Subhasish; Teja, K. Charan; Mukherjee, Sandip; Seal, Soma; Sah, Rajesh Kumar; Duary, B.; Kim, Ki‐Hyun; Bhattacharya, Suvendu

doi:10.1016/j.envres.2017.11.054

Cited by 21 publications

(12 citation statements)

References 49 publications

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“…As an isomer of schaftoside, isoschaftoside (Isosch) was also found to be an allelochemical against the development of Striga (Hooper et al 2010 ). Carlinoside (luteolin 6- C -glucosyl-8- C -arabinoside) from Cajanus plants shows antihepatitic and bilirubin solubilization activity (Das et al 2018 ). Recently, both schaftoside and carlinoside were identified as active ingredients against COVID-19.…”

Section: Introductionmentioning

confidence: 99%

De novo biosynthesis of C-arabinosylated flavones by utilization of indica rice C-glycosyltransferases

Chen

Sun

Wang

et al. 2021

Bioresour. Bioprocess.

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Flavone C-arabinosides/xylosides are plant-originated glycoconjugates with various bioactivities. However, the potential utility of these molecules is hindered by their low abundance in nature. Engineering biosynthesis pathway in heterologous bacterial chassis provides a sustainable source of these C-glycosides. We previously reported bifunctional C-glucosyl/C-arabinosyltransferases in Oryza sativa japonica and O. sativa indica, which influence the C-glycoside spectrum in different rice varieties. In this study, we proved the C-arabinosyl-transferring activity of rice C-glycosyltransferases (CGTs) on the mono-C-glucoside substrate nothofagin, followed by taking advantage of specific CGTs and introducing heterologous UDP-pentose supply, to realize the production of eight different C-arabinosides/xylosides in recombinant E. coli. Fed-batch fermentation and precursor supplement maximized the titer of rice-originated C-arabinosides to 20–110 mg/L in an E. coli chassis. The optimized final titer of schaftoside and apigenin di-C-arabinoside reached 19.87 and 113.16 mg/L, respectively. We demonstrate here the success of de novo bio-production of C-arabinosylated and C-xylosylated flavones by heterologous pathway reconstitution. These results lay a foundation for further optimal manufacture of complex flavonoid compounds in microbial cell factories.

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Section: Introductionmentioning

confidence: 99%

De novo biosynthesis of C-arabinosylated flavones by utilization of indica rice C-glycosyltransferases

Chen

Sun

Wang

et al. 2021

Bioresour. Bioprocess.

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“…Organic acids released during vermicomposting result in the solubilization of P from P-bearing minerals, thus enhancing P bio-availability. Unlike chemical fertilizers, vermicomposts have several benefits such as improving both the bio-chemical and physical properties of the soil whilst increasing health related secondary metabolites in plants ( Goswami et al., 2017 ; Das et al., 2018 ). Although several researchers have looked at the potential of composts and vermicompost on P release from rock phosphate, much of the work was based on amendment of mature composts or non-optimized vermicomposts, reducing the potential mineralization benefits of the composting processes ( Kumar and Singh, 2001 ; Aria et al., 2010 ; Busato et al., 2012 ).…”

Section: Introductionmentioning

confidence: 99%

Vermicomposting manure-paper mixture with igneous rock phosphate enhances biodegradation, phosphorus bioavailability and reduces heavy metal concentrations

Mupondi

Mnkeni

Muchaonyerwa

et al. 2018

Heliyon

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In organic soil fertility management, rock phosphate (RP) is gaining momentum as an acceptable phosphorus source, though much of this P is not bioavailable for plant uptake, particularly in igneous RP. This study evaluated the nutrient solubilization, biodegradation and heavy metal concentration when cow dung – waste paper mixture amended with increasing rates of igneous RP was vermicomposted with E. fetida. The cow dung was optimized to a C/N ratio of 30 using waste paper and amended with RP to provide 0%; 2%; 4% and 8% of elemental phosphorus on a dry w/w basis. Incorporation of RP at 2% and 8% P enhanced compost biodegradation resulting in a 12% and 22% significantly (P < 0.001) lower final C/N ratio, respectively, compared to the control; together with higher humification parameters. Amending the cow dung – waste paper mixture with 2%, 4% and 8% P as rock phosphate, resulted in a 39%; 50% and 65% more resin extractable P, respectively, relative to the control. Similarly, the bicarbonate extractable P, which represents the bioavailable P fraction, increased consistently by 19%; 28% and 33% following 2%, 4% and 8% RP application, respectively. Though incorporation of RP initially resulted in increased heavy metal levels, reductions of 40%; 35%; 35%; 40% and 45% for Cr, Cu, Cd, Pb and Zn, respectively, were observed in the 8% RP treatment after 8 weeks, due to the presence of earthworms. Vermicomposting with E. fetida significantly reduced heavy metals to levels below the maximum permissible concentration of potentially toxic elements in soils after 8 weeks. This study demonstrates the potential of optimized vermicomposting with igneous RP for generating nutrient rich organic fertilizers.

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“…Indeed, this approach revealed that nine other ligands form a hydrogen bond with His41, Cys145, and Gln166 (Figure 3(a-i)). In addition to these key interactions, ligands also establish contacts with the protease via water mediated hydrogen bonds, hydrophobic and other [24,25] and are good antiviral candidates [26,27] with several available natural sources including unfermented Rooibos tea [28]. The results of this investigation should not be taken as medical advice or encouragement for people to take supplements of these compounds as excessive intake of flavonoids may cause adverse effects on human health, including the inhibition of thyroid hormone synthesis [29].…”

Section: Protein-ligand Interaction -A Contact Analysismentioning

confidence: 97%

Structure-Based Virtual Screening of a Natural Product Database to Identify Several Possible SARS-CoV-2 Main Protease Inhibitors

Ramaprasad

Merrill²,

Durkin³

et al. 2020

Preprint

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<p>A novel coronavirus (SARS-CoV-2) has been the cause of a recent pandemic of respiratory illness known as COVID-19. The lack of anti-viral drugs or vaccines to control the infection has resulted in an enormous number of seriously ill patients requiring hospitalization. In the absence of an effective vaccine, there is an urgent need for therapies which can fight COVID-19 infection. Readily available compounds in foods and plants may be one source of anti-viral compounds. Here, natural product chemicals from the Nuclei of Bioassays, Ecophysiology and Biosynthesis of Natural Products Database (NuBBE<sub>DB</sub>) were screened against the main protease (Mpro) of SARS-CoV-2. This protease was chosen as a target due to its importance in the replication of SARS-CoV-2. Molecular docking was used to screen the natural products against Mpro to identify potential candidates. The identified candidates were further filtered using molecular dynamics simulation investigation. Nine natural compounds were identified for experimental validation, with carlinoside and quercetin 3-o-sophoroside being the top candidates. </p>

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Impact of edaphic factors and nutrient management on the hepatoprotective efficiency of Carlinoside purified from pigeon pea leaves: An evaluation of UGT1A1 activity in hepatitis induced organelles

Cited by 21 publications

References 49 publications

De novo biosynthesis of C-arabinosylated flavones by utilization of indica rice C-glycosyltransferases

De novo biosynthesis of C-arabinosylated flavones by utilization of indica rice C-glycosyltransferases

Vermicomposting manure-paper mixture with igneous rock phosphate enhances biodegradation, phosphorus bioavailability and reduces heavy metal concentrations

Structure-Based Virtual Screening of a Natural Product Database to Identify Several Possible SARS-CoV-2 Main Protease Inhibitors

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