Impact of diminazene aceturate on renin-angiotensin system, infectious myocarditis and skeletal myositis in mice: An in vitro and in vivo study

Silva, Thaiany Goulart de Souza e; Vilas-Boas, Diego F.; Gonçalves-Santos, Elda; Mazzeti, Ana Lia; Caldas, Ivo Santana; Gonçalves, Reggiani Vilela; Diniz, Lívia de Figueiredo; Novaes, Rômulo Dias

doi:10.1016/j.lfs.2020.118067

Cited by 8 publications

(2 citation statements)

References 52 publications

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“…Supporting this previous hypothesis, our histological results demonstrated that resistance exercise training alone or combined with whey protein supplementation reduced the pathological microstructural remodeling response induced by muscle injury. Although interstitial cellularity is used as a marker of muscle microstructural inflammatory damage ( Novaes et al, 2017 ; Souza-Silva et al, 2020 ), the cell types involved in muscle inflammation and repair have not been investigated. Thus, a potential relationship between interstitial muscle cell phenotype and pain pathophysiology should be investigated in future studies.…”

Section: Discussionmentioning

confidence: 99%

Resistance Exercise and Whey Protein Supplementation Reduce Mechanical Allodynia and Spinal Microglia Activation After Acute Muscle Trauma in Rats

et al. 2021

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Muscle injury caused by direct trauma to the skeletal muscle is among the main musculoskeletal disorders. Non-pharmacological treatments have been effective in controlling muscle injury–induced pain; however, there are just a few studies in the literature investigating this response. Thus, the present study aimed to evaluate the effect of a resistance exercise training protocol combined or not with whey protein supplementation on mechanical allodynia induced by muscle injury. In addition, we also investigated the involvement of spinal glial cells in this process. For this purpose, male Wistar rats underwent a muscle injury model induced by direct trauma to the gastrocnemius muscle. Mechanical allodynia was measured by a digital von Frey algesimeter test. To evaluate the effect of exercise and/or supplementation on mechanical allodynia, the animals practiced exercises three times a week for 14 days and received supplementation daily for 14 days, respectively. Moreover, the effect of both the participation of spinal glial cells in the muscle injury and the resistance exercise training and/or whey protein supplementation on these cells was also investigated by the Western blot assay. The results demonstrated that resistance exercise training and whey protein supplementation, combined or alone, reduced mechanical allodynia. These treatments also reduced the number of interstitial cells and pro-inflammatory cytokine IL-6 levels in the injured muscle. It was also found that spinal microglia and astrocytes are involved in muscle injury, and that resistance exercise training combined with whey protein supplementation inhibits spinal microglia activation. The results suggest that both resistance exercise training and whey protein supplementation may be effective non-pharmacological treatments to control pain in the muscle after injury induced by acute trauma.

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Section: Discussionmentioning

confidence: 99%

Resistance Exercise and Whey Protein Supplementation Reduce Mechanical Allodynia and Spinal Microglia Activation After Acute Muscle Trauma in Rats

et al. 2021

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“…In clinical testing of COVID-19 patients, it was found that the level of angiotensin converting enzyme (ACE) was extremely low (8). A decline in ACE increases the risk of hypertension, myocarditis, and even heart failure (9)(10)(11). Meanwhile, the impact of 2019-nCoV on the nervous system is also very serious.…”

Section: Introductionmentioning

confidence: 99%

Complication and Sequelae of COVID-19: What Should We Pay Attention to in the Post-Epidemic Era

et al. 2021

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COVID-19 is widespread worldwide and seriously affects the daily life and health of humans. Countries around the world are taking necessary measures to curb the spread. However, COVID-19 patients often have at least one organ complication and sequelae in addition to respiratory symptoms. Controlling the epidemic is only a phased victory, and the complication and sequelae of COVID-19 will need more attention in the post-epidemic era. We collected general information from over 1000 articles published in 2020 after the COVID-19 outbreak and systematically analyzed the complication and sequelae associated with eight major systems in COVID-19 patients caused by ACE2 intervention in the RAS regulatory axis. The autoimmune response induced by 2019-nCoV attacks and damages the normal tissues and organs of the body. Our research will help medical workers worldwide address COVID-19 complication and sequelae.

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Oxidative stress, cardiomyocytes premature senescence and contractile dysfunction in in vitro and in vivo experimental models of Chagas disease

et al. 2023

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Impact of diminazene aceturate on renin-angiotensin system, infectious myocarditis and skeletal myositis in mice: An in vitro and in vivo study

Cited by 8 publications

References 52 publications

Resistance Exercise and Whey Protein Supplementation Reduce Mechanical Allodynia and Spinal Microglia Activation After Acute Muscle Trauma in Rats

Resistance Exercise and Whey Protein Supplementation Reduce Mechanical Allodynia and Spinal Microglia Activation After Acute Muscle Trauma in Rats

Complication and Sequelae of COVID-19: What Should We Pay Attention to in the Post-Epidemic Era

Oxidative stress, cardiomyocytes premature senescence and contractile dysfunction in in vitro and in vivo experimental models of Chagas disease

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