Impact of Dietary Zinc Oxide Nano-Particles on Antioxidant Status, Liver and Kidney Functions in Alexandria Chickens

Abdel-Monem, N; Elsebai, Azza; Elnagar, Samar A.; El-Hady, Ahmed Abd

doi:10.21608/epsj.2021.197911

Cited by 3 publications

(1 citation statement)

References 8 publications

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“…Our results were inappropriate with those obtained by Ahmadi et al [ 93 ], who sustained that total antioxidant capacity (TAC) and superoxide dismutase had significantly increased (P < 0.05) , as well malondialdehyde decreased (P > 0.05) in chicks fed a diet containing nano zinc oxide at a level of 60 or 90 ppm in comparison to other treatments. Abdel-Monem et al [ 94 ] and Dukare et al [ 95 ] revealed that an 80 mg NZnO/kg diet resulted in a significant elevation in SOD and TAC and a reduction of lipid peroxidation of chicken.. The non-significant conclusion of NZnO on the antioxidant activity might be associated with the level of zinc in the diet and might be due to the use of relatively higher concentrations of NZnO than used in previous studies.…”

Section: Discussionmentioning

confidence: 96%

Nano Zinc Oxide Improves Performance, IGF-I mRNA Expression, Meat Quality, and Humeral Immune Response and Alleviates Oxidative Stress and NF-κB Immunohistochemistry of Broiler Chickens

Alian

Samy

Ibrahim

et al. 2022

Biol Trace Elem Res

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A 35-day trial was set to explore the effects of different dietary zinc sources on growth, insulin-like growth factor I (IGF-I) mRNA expression, meat quality, immune response, antioxidant activity, and immunohistochemistry of nuclear factor kappa B (NF-κ7B) of broiler chickens. Ross 308 broiler chicks (n = 156) were randomly assigned into four experimental groups. The G1 received the basal control diet without zinc supplementation; the G2, G3, and G4 were supplemented with zinc oxide, zinc lysine, and nano zinc oxide, respectively, at a level of 40 mg Zn/kg diet. The data revealed that nano zinc oxide linearly improved the overall growth performance parameters. Nano zinc oxide linearly elevated (P < 0.001) mRNA expression of IGF-I followed by G3. The pH value of breast muscle in G4 shows a linearly decreasing value (P < 0.001). Also, the linearly highest expressible release volume percentage and lightness (L*) value with the lowest redness (a*) value (P < 0.05) were recorded in G4 and G3. A numerical increase in the total antibody titer was recorded on the 35th day in the G3 and G4. A numerical elevation in the superoxide dismutase (SOD) and a numerical reduction in the serum malondialdehyde (MDA) were recorded in the G4. The section of the liver from G4 revealed significantly very low expression of NF-κB staining. It is concluded that nano zinc oxide is considered the more trending zinc source. It had no negative effects on the health status and can be used in broiler diet premix.

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Section: Discussionmentioning

confidence: 96%

Nano Zinc Oxide Improves Performance, IGF-I mRNA Expression, Meat Quality, and Humeral Immune Response and Alleviates Oxidative Stress and NF-κB Immunohistochemistry of Broiler Chickens

Alian

Samy

Ibrahim

et al. 2022

Biol Trace Elem Res

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Effects of Zinc Oxide Nanoparticles on Growth, Carcass Characteristics and Intestinal Tight Junction Protein Gene Expression in 35-day old Broiler Chickens

Mozhiarasi

Karunakaran

Radhakrishnan

et al. 2022

Preprint

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In the present study, the effect of zinc oxide nanoparticles (ZnONPs) at different concentrations (20, 40 and 60 mg/kg) in broiler chicken diet on growth, carcass characteristics and intestinal health of broiler chicks were evaluated. The ZnONPs synthesized by physical method was characterized for its nanoparticle properties and evaluated for its in vitro toxicity using different cell lines. In vivo feeding trials was conducted with 150-day-old broiler chicks randomly assigned to five dietary treatments in three replicates for the period of 35 days with ZnONPs. The results indicated that ZnONPs supplemented group showed significantly higher (p < 0.05) body weight gain and the lower feed conversion ratio (FCR) compared to control. The carcass characteristics like meat pH and dressing percentage revealed the significance differences in the ZnONPs supplemented group. The intestinal histomorphology revealed significantly higher (p < 0.05) crypt depth in ileum and villi length to crypt depth ratio in duodenum of ZnONPs supplemented group. The zinc elemental concentration in the serum found to be significantly higher and the mRNA expression of intestinal tight junction protein genes like mucin-2 and claudin-3 found to be significantly upregulated in the ZnONPs supplemented group. It could be concluded that supplementation of ZnONPs in broiler diet could improve production performance, intestinal health status and can be used as an effective feed additive in broilers.

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Nano zinc supplementation compared with other zinc forms: effects on growth performance, serum concentrations, and economic evaluation in broiler chickens

Saber,

Alian

2024

Preprint

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The current study's aim was to assess how different zinc sources affected the broilers' growth performance, economic evaluation, and serum concentrations. One-day-old "Cobb" broiler chicks (n = 192) with an average initial body weight of 44.10 g and were randomly distributed into 6 groups. The 1st, 2nd, and 3rd groups were supplied with inorganic zinc oxide, inorganic zinc sulphate monohydrate, and organic zinc methionine, respectively, at a level of 100 mg Zn/kg diet. While the 4th, 5th, and 6th groups were supplied with nano zinc oxide (NZnO) at a level of 20, 10, and 5 mg Zn/kg diet, respectively. The study exposed that NZnO at a level of 5 mg Zn/kg (G6) achieved a significant improvement (P < 0.05) in final body weight and cumulative body weight gain, feed conversion ratio, and feed efficiency. Nano zinc oxide in G5 and G6 significantly achieved the best results in economic efficiency enhancement (P < 0.05). NZnO (G6) increased superoxide dismutase activity and HDL (high-density lipoprotein) levels either significantly (P < 0.05) compared to G1, G2, G3, and G4 or numerically with G5. The addition of NZnO lessens blood serum MDA (malondialdehyde), alanine aminotransferase and aspartate aminotransferase (ALT, AST), and creatinine levels. The nano zinc oxide in G4, G5, and G6 achieved the best performance, enhanced antioxidant activity, and improved lipid profiling, liver, and kidney functions. The positive results were more noticeable in the G6. Therefore, applying NZnO (5 mg Zn/kg diet) is a new promising feed additive in the broiler industry.

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Impact of Dietary Zinc Oxide Nano-Particles on Antioxidant Status, Liver and Kidney Functions in Alexandria Chickens

Cited by 3 publications

References 8 publications

Nano Zinc Oxide Improves Performance, IGF-I mRNA Expression, Meat Quality, and Humeral Immune Response and Alleviates Oxidative Stress and NF-κB Immunohistochemistry of Broiler Chickens

Nano Zinc Oxide Improves Performance, IGF-I mRNA Expression, Meat Quality, and Humeral Immune Response and Alleviates Oxidative Stress and NF-κB Immunohistochemistry of Broiler Chickens

Effects of Zinc Oxide Nanoparticles on Growth, Carcass Characteristics and Intestinal Tight Junction Protein Gene Expression in 35-day old Broiler Chickens

Nano zinc supplementation compared with other zinc forms: effects on growth performance, serum concentrations, and economic evaluation in broiler chickens

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