Impact of dietary supplementation with resistant dextrin (NUTRIOSE®) on satiety, glycaemia, and related endpoints, in healthy adults

Abstract

Purpose Resistant dextrin (RD) supplementation has been shown to alter satiety, glycaemia, and body weight, in overweight Chinese men; however, there are limited data on its effects in other demographic groups. Here, we investigated the effects of RD on satiety in healthy adults living in the United Kingdom. Methods 20 normal weight and 16 overweight adults completed this randomised controlled cross-over study. Either RD (14 g/day NUTRIOSE® FB06) or maltodextrin control was consumed in mid-morning and mid-afternoon preload beverages over a 28-day treatment period with crossover after a 28-day washout. During 10-h study visits (on days 1, 14, and 28 of each treatment period), satietogenic, glycaemic and anorectic hormonal responses to provided meals were assessed. Results Chronic supplementation with RD was associated with higher fasted satiety scores at day 14 (P = 0.006) and day 28 (P = 0.040), compared to control. RD also increased satiety after the mid-morning intervention drink, but it was associated with a reduction in post-meal satiety following both the lunch and evening meals (P < 0.01). The glycaemic response to the mid-morning intervention drink (0–30 min) was attenuated following RD supplementation (P < 0.01). Whilst not a primary endpoint we also observed lower systolic blood pressure at day 14 (P = 0.035) and 28 (P = 0.030), compared to day 1, following RD supplementation in the normal weight group. Energy intake and anthropometrics were unaffected. Conclusions RD supplementation modified satiety and glycaemic responses in this cohort, further studies are required to determine longer-term effects on body weight control and metabolic markers. Clinicaltrials.gov registration CT02041975 (22/01/2014)

Diet Supplementation with NUTRIOSE, a Resistant Dextrin, Increases the Abundance of Parabacteroides distasonis in the Human Gut

“…[61,62] The relation between P. distasonis and GLP-1 production is consistent with three clinical trials showing that RD improves satiety in healthy adults. [22,24,25] Given the impact of RD on specific strains of P. distasonis, we foresee that this fiber could be used to extend our understanding of its growth, function, and interaction with the host. However, this requires to apply the presented analysis on larger and more diverse datasets.…”

“…[ 61 , 62 ] The relation between P. distasonis and GLP‐1 production is consistent with three clinical trials showing that RD improves satiety in healthy adults. [ 22 , 24 , 25 ]…”

“…Modification of gut microbiota included an increase in Bacteroides spp, a decrease in Clostridium perfringens and the production of several SCFAs. In other studies performed on either animal models, healthy volunteers or specific human populations (diabetic women), RD showed different beneficial health responses, such as antiobesogenic, [21][22][23][24][25][26] cholesterol-lowering, [27] anti-inflammatory, [28][29][30] or positive influence on the immune system response. [29] Most of the interventional (human) studies with fibers focused on specific taxa, targeting only Bifidobacterium and Lactobacillus, thus following the first prebiotic definition.…”

“…Modification of gut microbiota included an increase in Bacteroides spp, a decrease in Clostridium perfringens and the production of several SCFAs. In other studies performed on either animal models, healthy volunteers or specific human populations (diabetic women), RD showed different beneficial health responses, such as antiobesogenic, [ 21 , 22 , 23 , 24 , 25 , 26 ] cholesterol‐lowering, [ 27 ] anti‐inflammatory, [ 28 , 29 , 30 ] or positive influence on the immune system response. [ 29 ]…”

Efficiency of Resistant Starch and Dextrins as Prebiotics: A Review of the Existing Evidence and Clinical Trials

“…However, it must be noted that many of those preparations are not comprehensibly tested and should be used carefully. Considering these facts, it is crucial to have a balanced and diverse diet incorporating several types of plant-based foods that grant various types of dietary fibers, promoting the growth of particular kinds of intestinal microorganisms [48,49]. The main physicochemical properties of dietary fibers consist of fermentability, viscosity, and solubility.…”