Diet Supplementation with NUTRIOSE, a Resistant Dextrin, Increases the Abundance of Parabacteroides distasonis in the Human Gut

Abstract

Scope: An imbalance of the gut microbiota ("dysbiosis") is associated with numerous chronic diseases, and its modulation is a promising novel therapeutic approach. Dietary supplementation with soluble fiber is one of several proposed modulation strategies. This study aims at confirming the impact of the resistant dextrin NUTRIOSE (RD), a soluble fiber with demonstrated beneficial health effects, on the gut microbiota of healthy individuals. Methods and results: Fifty healthy women are enrolled and supplemented daily with either RD (n = 24) or a control product (n = 26) during 6 weeks. Characterization of the fecal metagenome with shotgun sequencing reveals that RD intake dramatically increases the abundance of the commensal bacterium Parabacteroides distasonis. Furthermore, presence in metagenomes of accessory genes from P. distasonis, coding for susCD (a starch-binding membrane protein complex) is associated with a greater increase of the species. This suggests that response to RD might be strain-dependent. Conclusion: Supplementation with RD can be used to specifically increase P. distasonis in gut microbiota of healthy women. The magnitude of the response may be associated with fiber-metabolizing capabilities of strains carried by subjects. Further research will seek to confirm that P. distasonis directly modulates the clinical effects observed in other studies.

Synthesis of Pyrodextrins and Enzymatically Resistant Maltodextrins from Makal (Xanthosoma yucatenensis) Starch

“…The percentage of indigestible material in the ERM of the present study is similar to Nutriose® (85 %) ( 35 ) and Fibersol® (90 %) ( 36 ), both maltodextrin-based resistant products currently marketed for human consumption.…”

Effect of Resistant Dextrin on Intestinal Gas Homeostasis and Microbiota

“…A prebiotic resistant dextrin (14 g/d NUTRIOSE ® FB06 soluble fibre, Roquette Frères, Lestrem, France) was administered in the morning (powder dissolved in water) during the 4 wk administration phase. This particular brand of resistant dextrin was chosen based on previous studies showing its modulatory effects on intestinal microbiota [ 5 , 6 , 7 ], as well as potential health benefits [ 8 , 9 , 10 ].…”

“…Studies in vitro have shown that a resistant dextrin soluble fibre is selectively consumed by Clostridium cluster XIVa and Roseburia genus and beneficially modifies microbiota metabolism [ 5 ]. Clinical studies confirmed the positive modulation of gut microbiota [ 6 , 7 ], and further showed that it is well-tolerated and exerts health benefits related to gut health, sustained energy, blood glucose management and satiety [ 8 , 9 , 10 ]. However, the effect of resistant dextrin on intestinal gas metabolism, a potential mechanism of digestive complaints, has not been investigated.…”

A flexible high-throughput cultivation protocol to assess the response of individuals’ gut microbiota to diet-, drug-, and host-related factors

“…4C ), consistent with previous ex vivo and in vivo studies [ 14 , 68 , 69 ]. Human trials also identified a dextrin-specific increase of Parabacteroides [ 14 , 70 ], which was increased in our ex vivo cultures (2 3.5 -fold increase), though the effect was not significant. Starch supplementation most prominently enriched Faecalibacterium ( P ≤ .01) and Agathobacter ( P ≤ .05; formerly Eubacterium, Fig.…”