Impact of dietary glutathione on hematological indices in rats poisoned with hexavalent chromium

Abstract

Abstract:The effects of dietary glutathione against chromium induced hematological indices were studied in rats, Rattus rattus albino. Supplementation of glutahione to the diet of chromium fed rats, elevated significantly percent hemoglobin (40.4%), number of red blood corpuscles (48.7%), plasma corpuscular volume (43.4%) and mean corpuscular volume (37.1%) which were inhibited in chromium poisoned rats. However, no marked elevation was noticed in number of white blood corpuscles and total proteins. Intake of glutahione checked the accumulation of glucose, cholesterol, tryglcerides, phospholipids and bilirubin in chromium treated rats. Chromium intoxication significantly increased the activities of transaminases (p<0.001) and dehydrogenases (p<0.01/p<0.001) which declined by supplementation of gltathione which also restored the chromium inhibited activity of alkaline and acid phosphatase. Specific reasons for these pharmacoticological aspects of glutathione have also been discussed.

Effects of metals cadmium and chromium alone and in combination on the liver and kidney tissue of male Spraque‐Dawley rats: An ultrastructural and electron‐energy‐loss spectroscopy investigation

“…Compared to the control, creatinine levels were significantly lower in the metal combination group and may indicate renal tubular dysfunction (Asagba & Obi ; Babaknejad, Moshtaghie, Shahanipour, & Bahrami, ). Several researchers have also reported lower ALP and creatinine levels after exposed to Cr (Kumar & Kumar, ; Kumar, Rana, & Prakash, ). The TP and bilirubin levels (although the latter was not significant) were altered and may suggest early changes in liver and kidney function.…”