Impact of dietary components on enteric infectious disease

Cao, Yu; Liu, Jiaxiu; Zhu, Wenxiu; Qin, Ningbo; Ren, Xiaomeng; Zhu, Beiwei; Xia, Xiaodong

doi:10.1080/10408398.2021.1871587

Cited by 10 publications

(8 citation statements)

References 128 publications

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“…Thus, C. rodentium allows further study of how deprivation of dietary fiber impacts the complex ecological interactions between the gut microbiome, enteropathogens and the host. This, in turn, can aid in understanding the associations of Western dietary patterns with increased susceptibility to enteric pathogens 12 . The lessons learned from such a model could furthermore eventually inform strategies for designing customized diets to reduce the burden of enteric infections.…”

Section: Introductionmentioning

confidence: 99%

Deprivation of dietary fiber in specific-pathogen-free mice promotes susceptibility to the intestinal mucosal pathogen Citrobacter rodentium

Neumann

Steimle

Grant

et al. 2021

Preprint

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The change of dietary habits in Western societies, including reduced consumption of fiber, is linked to alterations in gut microbial ecology. Nevertheless, mechanistic connections between diet-induced microbiota changes that affect colonization resistance and enteric pathogen susceptibility are still emerging. We sought to investigate how a diet devoid of soluble plant fibers impacts the structure and function of a conventional gut microbiota in specific-pathogen-free (SPF) mice and how such changes alter susceptibility to a rodent enteric pathogen. We show that absence of dietary fiber intake leads to shifts in the abundances of specific taxa, microbiome-mediated erosion of the colonic mucus barrier, a reduction of intestinal barrier-promoting short-chain fatty acids, and increases in markers of mucosal barrier integrity disruption. Importantly, our results highlight that these low fiber diet-induced changes in the gut microbial ecology collectively contribute to a lethal colitis by the mucosal pathogen Citrobacter rodentium, which is used as a mouse model for enteropathogenic and enterohemorrhagic Escherichia coli (EPEC and EHEC, respectively). Our study indicates that modern, low-fiber Western diets might make individuals more prone to infection by enteric pathogens via the disruption of mucosal barrier integrity by diet-driven changes in the gut microbiota, illustrating possible implications for EPEC and EHEC infections.

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Section: Introductionmentioning

confidence: 99%

Deprivation of dietary fiber in specific-pathogen-free mice promotes susceptibility to the intestinal mucosal pathogen Citrobacter rodentium

Neumann

Steimle

Grant

et al. 2021

Preprint

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“…On the other hand, emerging evidence indicates that dietary fiber can protect the GIT from pathogen infection. For instance, dietary fiber may directly inhibit enteric pathogens or indirectly influence infections by modulating the gut microbiota and immune function (Cao et al, 2021). Andrew et al indicated that microbiota-accessible carbohydrates (MACs) decrease the expression of C. difficile toxin and suppress the infection of C. difficile in mice (Hryckowian et al, 2018).…”

Section: Dietary Fibermentioning

confidence: 99%

Crosstalk Between the Gut Microbiota and Epithelial Cells Under Physiological and Infectious Conditions

Zhou

Yuan

Yang

et al. 2022

Front. Cell. Infect. Microbiol.

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The gastrointestinal tract (GIT) is considered the largest immunological organ, with a diverse gut microbiota, that contributes to combatting pathogens and maintaining human health. Under physiological conditions, the crosstalk between gut microbiota and intestinal epithelial cells (IECs) plays a crucial role in GIT homeostasis. Gut microbiota and derived metabolites can compromise gut barrier integrity by activating some signaling pathways in IECs. Conversely, IECs can separate the gut microbiota from the host immune cells to avoid an excessive immune response and regulate the composition of the gut microbiota by providing an alternative energy source and releasing some molecules, such as hormones and mucus. Infections by various pathogens, such as bacteria, viruses, and parasites, can disturb the diversity of the gut microbiota and influence the structure and metabolism of IECs. However, the interaction between gut microbiota and IECs during infection is still not clear. In this review, we will focus on the existing evidence to elucidate the crosstalk between gut microbiota and IECs during infection and discuss some potential therapeutic methods, including probiotics, fecal microbiota transplantation (FMT), and dietary fiber. Understanding the role of crosstalk during infection may help us to establish novel strategies for prevention and treatment in patients with infectious diseases, such as C. difficile infection, HIV, and COVID-19.

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“…However, an increasing number of studies have started to focus on the alteration of a host’s immune system in response to the infection. Dietary components are known to affect host physiology and modulate the mucosal innate immune system, directly or indirectly through gut microbiota . A short-term high-fat diet increased a host’s susceptibility to Listeria monocytogenes infection through physiological and microbiota changes, indicating that diet can significantly influence susceptibility to infectious diseases .…”

Section: Introductionmentioning

confidence: 99%

“…Dietary components are known to affect host physiology and modulate the mucosal innate immune system, directly or indirectly through gut microbiota. 13 A short-term high-fat diet increased a host's susceptibility to Listeria monocytogenes infection through physiological and microbiota changes, indicating that diet can significantly influence susceptibility to infectious diseases. 14 Diet is an important environmental factor that induces enteric dysfunction.…”

Section: ■ Introductionmentioning

confidence: 99%

Oxidized PUFAs Increase Susceptibility of Mice to Salmonella Infection by Diminishing Host’s Innate Immune Responses

Wang

Liu

et al. 2022

J. Agric. Food Chem.

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Dietary ω-3 PUFAs are highly prone to oxidation, and this may potentially limit their application in the healthpromoting field. Here, we sought to investigate whether and how oxidized PUFAs modulate the susceptibility of mice to Salmonella typhimurium (S. Tm) infection. Algae oil (AO) and oxidized algae oil (ox-AO) were administered to the C57BL/6 mice prior to S. Tm infection. Compared to the S. Tm group, ox-AO increased bacterial burden in systemic and intestinal tissues, downregulated host anti-infection responses, and developed worse colitis. In macrophages, ox-AO decreased both phagocytosis of S. Tm and clearance of intracellular bacteria and dampened the activation of mitogen-activated protein kinase (MAPK), NF-κB, and autophagy pathways. Furthermore, ox-AO diminished LPS-induced inflammatory cytokine production and S. Tm induced NLRC4 inflammasome activation. This study reveals that oxidized PUFAs may contribute to the development of enteric infections and regular monitoring of the oxidation status in commercial PUFA supplements to prevent their potential adverse impact on human health.

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Impact of dietary components on enteric infectious disease

Cited by 10 publications

References 128 publications

Deprivation of dietary fiber in specific-pathogen-free mice promotes susceptibility to the intestinal mucosal pathogen Citrobacter rodentium

Deprivation of dietary fiber in specific-pathogen-free mice promotes susceptibility to the intestinal mucosal pathogen Citrobacter rodentium

Crosstalk Between the Gut Microbiota and Epithelial Cells Under Physiological and Infectious Conditions

Oxidized PUFAs Increase Susceptibility of Mice to Salmonella Infection by Diminishing Host’s Innate Immune Responses

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