Impact of Dialysis Modality on Posttransplantation Results in Kidney Transplantation

Helal, Imed; Abderrahim, E.; Hamida, F. Ben; Zouaghi, K.; Ounissi, M.; Barbouche, S.; Hedri, H.; Ezzine, S.; Abdallah, I. Ben; Chrif, M.; Bardi, R.; Ayed, K; Maı̈z, H. Ben; Abdallah, T. Ben; Kheder, A.

doi:10.1016/j.transproceed.2007.08.017

Cited by 11 publications

(10 citation statements)

References 5 publications

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“…While some studies have failed to find a difference in outcomes [12, 16–18], others have found PD to have beneficial effects after renal transplantation compared to HD [1, 13, 19]. Our findings are similar to the studies [3, 13, 19] that have shown PD to have a protective effect on lowering the rate of DGF.…”

Section: Discussionsupporting

confidence: 86%

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The Mode of Pretransplant Dialysis Does Not Affect Postrenal Transplant Outcomes in African Americans

Sharma

Teigeler

Behnke

et al. 2012

Journal of Transplantation

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Background. In previous reports with a majority of Caucasian patients, peritoneal dialysis (PD) before kidney transplantation has been associated with poor outcomes and higher rates of graft thrombosis and infectious complications than hemodialysis (HD). We report our experience on the outcomes of prerenal transplant peritoneal dialysis in predominantly (73%) African American patient population. Methods. A retrospective data analysis of 401 kidney transplants performed at our center from 2000 to 2006 was performed. Adult recipients with at least three months of pretransplant HD or PD were included. Results. There were 339 patients on HD and 62 patients on PD. There was no difference in graft (P = 0.51) and patient survival (P = 0.52) at 1, 3, and 5-years. Patients on HD were more likely to experience delayed graft function than PD (38.8% versus 17.7%, P < 0.005). There was no difference in the incidence of vascular thrombosis or posttransplant infectious complications. When only the African American patients in the two groups were compared, there were no differences in graft or patient survival. Conclusions. Pretransplant peritoneal dialysis is associated with excellent patient and renal allograft outcomes in African Americans and does not predispose them to an increased risk of infectious or thrombotic complications.

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Section: Discussionsupporting

confidence: 86%

“…While some studies [12, 20] have shown the length of time on dialysis to affect transplant outcomes, we did not find any such association in this analysis. Like others [12, 16, 18], we observed that the dialysis modality and race did not independently affect graft outcomes.…”

Section: Discussionsupporting

confidence: 82%

The Mode of Pretransplant Dialysis Does Not Affect Postrenal Transplant Outcomes in African Americans

Sharma

Teigeler

Behnke

et al. 2012

Journal of Transplantation

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“…Whereas the lower incidence in delayed graft function among PD patients compared to those on HD has been confirmed by other studies [60][61][62], the effect on long-term graft survival is not established, with some studies showing a benefit [60] and others no effect [61,62].…”

Section: Pd and Kidney Transplantationmentioning

confidence: 93%

Home dialysis as a first option: a new paradigm

et al. 2009

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Traditionally, the initial choice of dialysis for patients with end stage renal disease (ESRD) has been in-center hemodialysis (HD) or peritoneal dialysis (PD). Usually, the choice between these (PD vs. HD) has been based on the characteristics of the dialysis techniques. Obviously the choice of peritoneal dialysis implied dialysis at home, but its geographic location has been only a secondary consideration. Peritoneal dialysis has evolved as a dependable mode that gives good outcomes. This method has become more attractive with the option of overnight cyclers and the recent use of home helpers in some jurisdictions. At the same time the interest in home hemodialysis was rekindled by reports of good outcomes with short daily or nocturnal hemodialysis. Home dialysis (PD or HD) offers high quality of treatment, a high degree of patient independence, and is financially attractive. Therefore, we propose a change in our approach to the choice of the initial form of dialysis for patients with ESRD. Instead of choosing between HD and PD we should present the new patients the advantage of dialysis at home and instead of asking them to choose between peritoneal dialysis or hemodialysis, they should be offered the option to choose between dialysis at home (PD or HD) or in-hospital. This paper will review the advantages of the home-based dialysis methods and the arguments for this simple but vital change in the process of choosing the method of dialysis.

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“…In contrast, other studies have found better outcomes in patients receiving PD, including lower rates of delayed graft function (DGF) or shorter time on dialysis . Finally, some authors have reported no significant differences between both dialysis modalities in terms of the risk of DGF, acute tubular necrosis, graft rejection, infection, thrombosis, NODAT, or graft and patient survival …”

Section: Introductionmentioning

confidence: 98%

“…13,15,20,21 Finally, some authors have reported no significant differences between both dialysis modalities in terms a Both authors contributed equally to this study. of the risk of DGF, [22][23][24] acute tubular necrosis, 22,[24][25][26] graft rejection, [22][23][24][25] infection, 22 thrombosis, 22 NODAT, 27 or graft and patient survival. 18,[22][23][24][25][26][28][29][30] These inconsistent results may be due to factors that are unrelated to dialysis modality, such as donor characteristics or differences in methodological design (i.e., registry-based or single-center studies).…”

Section: Introductionmentioning

confidence: 99%

Pre‐transplant dialysis modality does not influence short‐ or long‐term outcome in kidney transplant recipients: analysis of paired kidneys from the same deceased donor

Dipalma

Fernández‐Ruiz

Praga

et al. 2016

Clinical Transplantation

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Previous studies have reported contradictory results regarding the effect of pre-transplant dialysis modality on the outcomes after kidney transplantation (KT). To minimize the confounding effect of donor-related variables, we performed a donor-matched retrospective comparison of 160 patients that received only one modality of pre-transplant dialysis (peritoneal dialysis [PD] and hemodialysis [HD] in 80 patients each) and that subsequently underwent KT at our center between January 1990 and December 2007. Cox regression models were used to evaluate the association between pre-transplant dialysis modality and primary study outcomes (death-censored graft survival and patient survival). To control for imbalances in recipient-related baseline characteristics, we performed additional adjustments for the propensity score (PS) for receiving pre-transplant PD (versus HD). There were no significant differences according to pre-transplant dialysis modality in death-censored graft survival (PS-adjusted hazard ratio [aHR]: 0.65; 95% confidence interval [95% CI]: 0.25-1.68) or patient survival (aHR: 0.58; 95% CI: 0.13-2.68). There were no differences in 10-year graft function or in the incidence of post-transplant complications either, except for a higher risk of lymphocele in patients undergoing PD (odds ratio: 4.31; 95% CI: 1.15-16.21). In conclusion, pre-transplant dialysis modality in KT recipients does not impact short- or long-term graft outcomes or patient survival.

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Impact of Dialysis Modality on Posttransplantation Results in Kidney Transplantation

Cited by 11 publications

References 5 publications

The Mode of Pretransplant Dialysis Does Not Affect Postrenal Transplant Outcomes in African Americans

The Mode of Pretransplant Dialysis Does Not Affect Postrenal Transplant Outcomes in African Americans

Home dialysis as a first option: a new paradigm

Pre‐transplant dialysis modality does not influence short‐ or long‐term outcome in kidney transplant recipients: analysis of paired kidneys from the same deceased donor

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