Impact of Diabetes Mellitus and Insulin Use on Survival After Colorectal Cancer Diagnosis: The Cancer Prevention Study-II Nutrition Cohort

Dehal, Ahmed; Newton, Christina C.; Jacobs, Eric J.; Patel, Alpa V.; Gapstur, Susan M.; Campbell, Peter T.

doi:10.1200/jco.2011.38.0303

Cited by 100 publications

(99 citation statements)

References 31 publications

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“…It is possible that DM has different prognostic association on colon and rectal cancer. In a large prospective cohort, however, Dehal et al [24] showed that DM was nonsignificantly associated with higher cancer-specific mortality (relative risk, 1.29; 95% CI, 0.98 to 1.70) in patients with nonmetastatic "colorectal" cancer. Furthermore, a singleinstitute study showed that DM was significantly associated with shorter CSS in patients with resected stage I to stage III colon cancer when no adjustments for adjuvant chemotherapy and comorbidities were made in the multivariate analysis [12].…”

Section: Discussionmentioning

confidence: 96%

Type 2 Diabetes Mellitus Is Associated With Increased Mortality in Chinese Patients Receiving Curative Surgery for Colon Cancer

et al. 2014

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Background. We investigated the association between diabetes mellitus (DM) and the prognosis of patients with early colon cancer who had undergone curative surgery. Methods. From three national databases of patients in Taiwan, we selected a cohort of colon cancer patients who had been newly diagnosed with stage I or stage II colon cancer between January 1, 2004 and December 31, 2008 and had undergone curative surgery. We collected information regarding DM (type 2 DM only), the use of antidiabetic medications, other comorbidities, and survival outcomes. The colon cancer-specific survival (CSS) and the overall survival (OS) were compared between patients with and without DM. Results. We selected 6,937 colon cancer patients, among whom 1,371 (19.8%) had DM. The colon cancer patients with DM were older and less likely to receive adjuvant

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Section: Discussionmentioning

confidence: 96%

Type 2 Diabetes Mellitus Is Associated With Increased Mortality in Chinese Patients Receiving Curative Surgery for Colon Cancer

et al. 2014

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“…Pre-existing diabetes at cancer diagnosis is also associated with poorer overall survival in patients with colorectal cancer (CRC) [5][6][7][8][9][10][11][12][13]. However, investigation of cause-specific mortality in this context has been limited, and findings have been mixed.…”

Section: Introductionmentioning

confidence: 99%

“…However, investigation of cause-specific mortality in this context has been limited, and findings have been mixed. Three studies report a relationship between diabetes and increased CRC mortality [11][12][13], although, in one of these [13], increased CRC mortality was observed in people with diabetes who were diagnosed with rectal cancer but not in those with colon cancer. Two further investigations found no significant effect of diabetes on CRC-specific mortality [8,10].…”

Section: Introductionmentioning

confidence: 99%

“…The mixed evidence for an effect of diabetes on death specifically from CRC suggests that the observed poorer overall survival may reflect an increased hazard of death from other causes. Diabetes is associated with increased mortality from cardiovascular disease (CVD) in many populations, but only one previous study [12] appears to have investigated associations between pre-existing diabetes and survival after CRC when death from CVD is defined as the endpoint. This study reported a significant relationship between pre-existing type 2 diabetes mellitus and higher CVD mortality.…”

Section: Introductionmentioning

confidence: 99%

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Cause-specific mortality in Scottish patients with colorectal cancer with and without type 2 diabetes (2000–2007)

et al. 2013

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Aims/hypothesis The objective of this study was to use Scottish national data to assess the influence of type 2 diabetes on (1) survival (overall and cause-specific) in multiple time intervals after diagnosis of colorectal cancer and (2) cause of death. Methods Data from the Scottish Cancer Registry were linked to data from a population-based national diabetes register. All people in Scotland diagnosed with nonmetastatic cancer of the colon or rectum in 2000-2007 were included. The effect of pre-existing type 2 diabetes on survival over four discrete time intervals (<1, 1-2, 3-5 and >5 years) after cancer diagnosis was assessed by Cox regression. Cumulative incidence functions were calculated representing the respective probabilities of death from the competing causes of colorectal cancer, cardiovascular disease, other cancers and any other cause. Results Data were available for 19,505 people with colon or rectal cancer (1,957 with pre-existing diabetes). Causespecific mortality analyses identified a stronger association between diabetes and cardiovascular disease mortality than that between diabetes and cancer mortality. Beyond 5 years after colon cancer diagnosis, diabetes was associated with a detrimental effect on all-cause mortality after adjustment

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“…Diabetes has been linked with an increased risk of several cancers, including CRC [4][5][6]. Furthermore, diabetes has been associated with increased mortality and poorer clinical outcomes among persons with CRC [7,8]. It is therefore important that persons with diabetes receive CRC screenings according to age-appropriate guidelines [4].…”

Section: Introductionmentioning

confidence: 99%

Exploring opportunities for colorectal cancer screening and prevention in the context of diabetes self-management: an analysis of the 2010 National Health Interview Survey

Adjaye-Gbewonyo

Sabatino

White

2013

Behav. Med. Pract. Policy Res.

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Because diabetes is associated with increased colorectal cancer (CRC) risk, it is important that people with diabetes receive CRC screenings according to guidelines. In addition, many diabetes self-care recommendations are associated with a reduced risk of CRC. This study aims to identify potential opportunities for enhancing CRC prevention within the context of diabetes management. Using data from 1,730 adults with diabetes aged 50-75 years who responded to the 2010 National Health Interview Survey, we calculated population estimates of behaviors consistent with US Preventive Services Task Force guidelines for CRC screening and American Diabetes Association recommendations for diabetes care. We examined bivariate associations between CRC screening and selected diabetes self-care behaviors associated with CRC risk. Results were stratified by demographic characteristics. Thirty-nine percent of adults with diagnosed diabetes were not up-to-date with CRC screenings. Sixteen percent smoked and 2 % exceeded alcohol intake recommendations. Among those capable of exercise, 69 and 90 % did not meet aerobic exercise and resistance training recommendations, respectively.

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Impact of Diabetes Mellitus and Insulin Use on Survival After Colorectal Cancer Diagnosis: The Cancer Prevention Study-II Nutrition Cohort

Abstract: Patients with CRC and T2DM have a higher risk of mortality than patients with CRC who do not have T2DM, especially a higher risk of death from CVD.

Cited by 100 publications

References 31 publications

Type 2 Diabetes Mellitus Is Associated With Increased Mortality in Chinese Patients Receiving Curative Surgery for Colon Cancer

Type 2 Diabetes Mellitus Is Associated With Increased Mortality in Chinese Patients Receiving Curative Surgery for Colon Cancer

Cause-specific mortality in Scottish patients with colorectal cancer with and without type 2 diabetes (2000–2007)

Exploring opportunities for colorectal cancer screening and prevention in the context of diabetes self-management: an analysis of the 2010 National Health Interview Survey

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