Impact of demographic, genetic, and bioimpedance factors on gestational weight gain and birth weight in a Romanian population

Mărginean, Cristina Oana; Bănescu, Claudia; Meliţ, Lorena Elena; Tripon, Florin; Iancu, Mihaela

doi:10.1097/md.0000000000004098

Cited by 29 publications

(37 citation statements)

References 56 publications

(96 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Also, two studies performed in Caucasians showed associations between rs1800796 and obesity. In one of the reports, the rs1800796 C-allele was shown to be associated with obesity in children (26), and in the other study, they observed that pregnant women who carry the rs1800796 G-allele were protected from gestational weight gain (27). However, a study performed in a Dutch cohort observed smaller waist circumference in rs1800796-CC individuals compared with G-carriers (28).…”

Section: Discussionmentioning

confidence: 96%

Association of interleukin‐6 polymorphisms with obesity or metabolic traits in young Mexican‐Americans

Boeta-Lopez

Durán

Elizondo

et al. 2017

Obesity Science & Practice

View full text Add to dashboard Cite

SummaryObjectiveThe objective of the study is to investigate the association of interleukin‐6 (IL6) promoter single‐nucleotide polymorphisms rs1800797 (‐597 G/A) and rs1800796 (‐572 G/C) with obesity or metabolic syndrome in Mexican‐Americans.MethodsThe rs1800797 and rs1800796 single‐nucleotide polymorphisms were genotyped in Mexican‐Americans (n = 437) from South Texas, and results were correlated with measures of obesity and metabolic syndrome including body mass index, waist circumference, blood pressure, cholesterol, triglycerides, glucose, liver enzymes, plasma IL6 and high‐sensitive C‐reactive protein (hs‐CRP).ResultsSignificant associations were found for the rs1800796 variant with increased waist circumference, insulin resistance, lower IL6 levels and higher hs‐CRP levels. The rs1800797 variant showed no associations with metabolic traits but was associated with higher IL6 levels and lower hs‐CRP levels.ConclusionsFindings in this study support the anti‐inflammatory, anti‐obesity and glucose homeostatic roles of IL6 in Mexican‐American youth.

show abstract

Section: Discussionmentioning

confidence: 96%

Association of interleukin‐6 polymorphisms with obesity or metabolic traits in young Mexican‐Americans

Boeta-Lopez

Durán

Elizondo

et al. 2017

Obesity Science & Practice

View full text Add to dashboard Cite

show abstract

“…[67] The authors also emphasized that the variant genotype of the IL-6-572C > G polymorphism was a protection factors against the development of mother obesity. [67] …”

Section: Discussionmentioning

confidence: 99%

The role of TGF-β1 869 T > C and PPAR γ2 34 C > G polymorphisms, fat mass, and anthropometric characteristics in predicting childhood obesity at birth

Mărginean

Iancu²,

Szabó

et al. 2016

Medicine

Self Cite

View full text Add to dashboard Cite

This study proposed to establish a correlation between the risk score for child obesity and anthropometric, genetic, and bioimpedance characteristics in mothers and newborns, and to assess the discriminant ability for anthropometric parameters to classify over-fatness (defined by bioimpedance body fatness %) in pregnant women.We performed a cross-sectional study on 388 couples (mother and father) and their newborns admitted in a Tertiary Hospital from Romania. The measured parameters for mothers and their newborns were risk percentage for child obesity, anthropometric characteristics (mid-upper arm circumference [MUAC], tricipital skinfold thickness [TST] of mother and newborn), genetic polymorphisms (human peroxisome proliferator-activated receptor γ [PPARγ2] 34 C > G and transforming growth factor-beta 1 [TGF-β1] 869 T > C gene polymorphisms in both mothers and newborns), and mother's bioimpedance characteristics (fat mass [FM] %).The obesity risk score according to standard predictable Northern Finland Birth Cohort equation was in our study 4.07%. We found a monotone positive significant correlation between the newborn's risk of childhood obesity and the mother's TST (P = 0.01), as well as a tendency toward statistical significance concerning correlation with mother's MUAC (P = 0.053), without any correlations with the mothers’ bioimpedance parameters and also a positive correlation between the newborn's risk of childhood obesity and the newborn's anthropometrical characteristics like body mass index (BMI), MUAC, and TST (P < 0.001). We observed that the calculated newborn's risk percentage for child obesity was greater for the variant allele of the TGF-β1 869 T > C polymorphism and also for the wild-type C allele of the PPARγ2 34 C > G gene polymorphism. Our study indicated that the best predictors for over-fatness are BMI and MUAC (P = 0.01 < 0.02 and P = 0.019 < 0.02, respectively).

show abstract

“…[10,11] The critical periods for the onset of obesity are: pregnancy , [11,12] ‘adiposity rebound’ childhood development (age 3–6 years), [13] and puberty . [14] Identification of risk factors for obesity even since the first days of life and diminishment of obesity incidence in pregnant woman and child have a great impact also on the adult's health, preventing complications of this disorder. [15,16] …”

Section: Introductionmentioning

confidence: 99%

The FTO rs9939609 and LEPR rs1137101 mothers–newborns gene polymorphisms and maternal fat mass index effects on anthropometric characteristics in newborns

et al. 2016

Self Cite

View full text Add to dashboard Cite

The aim of this study was to assess the impact of mothers’ and newborns’ fat mass and obesity-associated gene (FTO) rs9939609 and leptin receptor (LEPR) rs1137101 gene polymorphisms on neonatal anthropometric parameters in order to identify a potential risk for developing obesity.We performed a cross-sectional study on 355 mother–newborn couples in an Obstetrics Gynecology Tertiary Hospital from Romania, evaluated with regard to anthropometric parameters, clinical and laboratory parameters besides 2 genetic polymorphisms (FTO rs9939609 and LEPR rs1137101).Newborns with mothers carrying variant AT or AA genotype for FTO rs9939609 presented lower BMI (P = 0.012) and lower MUAC (P = 0.029). There was a significant interaction effect between newborn and mother LEPR rs1137101 polymorphism on birth weight (P = 0.009) and BMI (P = 0.007). We noticed significantly increased birth weight and BMI in newborns carriers of AG + GG genotype, coming from mothers with AA genotype (P = 0.006). There was no evidence of significant interaction effect between newborn and mother FTO rs9939609 polymorphism on the studied anthropometrical data (P > 0.05). In addition, lower BMI scores (P = 0.042) were observed in newborns carriers of TT genotype whose mothers had AA + AT genotype. Lower MUAC scores (P = 0.041) were noticed in newborns carriers of AA + AT genotype whose mothers had AA + AT genotype for FTO rs9939609 gene polymorphism. Newborns carriers of the AG + GG genotype (P = 0.003) of LEPR rs1137101 coming from mothers with increased FMI (upper tertile) had significantly increased BMIs.Presence of the variant A allele of FTO rs9939609 polymorphism in mothers decreased BMI and MUAC in newborns. The impact of LEPR rs1137101 polymorphism on BMI and birth weight in newborns differed depending on the presence/absence of the dominant LEPR allele in mothers. In addition, we noticed that maternal FMI presented a significant positive effect on newborns’ BMI by changing the effect of LEPR rs1137101.We can conclude that mothers’ FTO rs9939609 and LEPR rs1137101 gene polymorphisms presented an impact on birth weight and newborns’ BMI, therefore being involved in the newborns’ nutritional status and in the design of a potential protocol.

show abstract

Impact of demographic, genetic, and bioimpedance factors on gestational weight gain and birth weight in a Romanian population

Cited by 29 publications

References 56 publications

Association of interleukin‐6 polymorphisms with obesity or metabolic traits in young Mexican‐Americans

Association of interleukin‐6 polymorphisms with obesity or metabolic traits in young Mexican‐Americans

The role of TGF-β1 869 T > C and PPAR γ2 34 C > G polymorphisms, fat mass, and anthropometric characteristics in predicting childhood obesity at birth

The FTO rs9939609 and LEPR rs1137101 mothers–newborns gene polymorphisms and maternal fat mass index effects on anthropometric characteristics in newborns

Contact Info

Product

Resources

About