Association of interleukin‐6 polymorphisms with obesity or metabolic traits in young Mexican‐Americans

Boeta-Lopez, K.; Durán, Jorge A. Cano; Elizondo, Diana M.; Gonzales, Enrique; Rentfro, Anne R.; Schwarzbach, Andrea E.; Nair, Saraswathy

doi:10.1002/osp4.138

Cited by 26 publications

(31 citation statements)

References 37 publications

(61 reference statements)

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“…Compared to non-vegetarian dietary patterns, vegetarian dietary patterns generate increased microbially-generated short chain fatty acids, which reduce systemic inflammation (e.g., IL-6), increase hormonal satiety-signaling (e.g., glucagon-like peptide-1) and reduce insulin resistance (32, 33). Among Hispanic/Latino subjects, recent studies suggest that IL-6 may be elevated from a young age, and the link across the lifespan to higher rates of cardiometabolic disease may be due to specific IL-6 polymorphisms in Latino youth (34). Interestingly, adding IL-6 to our models examining association with vegetarian diet exposure did not alter the protective effect of the diet on obesity.…”

Section: Discussionmentioning

confidence: 99%

Plant-Based Diets Are Associated With Lower Adiposity Levels Among Hispanic/Latino Adults in the Adventist Multi-Ethnic Nutrition (AMEN) Study

et al. 2019

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Background: The Hispanic/Latino population in the US is experiencing high rates of obesity and cardio-metabolic disease that may be attributable to a nutrition transition away from traditional diets emphasizing whole plant foods. In the US, plant-based diets have been shown to be effective in preventing and controlling obesity and cardio-metabolic disease in large samples of primarily non-Hispanic subjects. Studying this association in US Hispanic/Latinos could inform culturally tailored interventions. Objective: To examine whether the plant-based diet pattern that is frequently followed by Hispanic/Latino Seventh-day Adventists is associated with lower levels of adiposity and adiposity-related biomarkers. Methods: The Adventist Multiethnic Nutrition Study (AMEN) enrolled 74 Seventh-day Adventists from five Hispanic/Latino churches within a 20 mile radius of Loma Linda, CA into a cross-sectional study of diet (24 h recalls, surveys) and health (anthropometrics and biomarkers). Results: Vegetarian diet patterns (Vegan, Lacto-ovo vegetarian, Pesco-vegetarian) were associated with significantly lower BMI (24.5 kg/m 2 vs. 27.9 kg/m 2 , p = 0.006), waist circumference (34.8 in vs. 37.5 in, p = 0.01), and fat mass (18.3 kg vs. 23.9 kg, p = 0.007), as compared to non-vegetarians. Adiposity was positively associated with pro-inflammatory cytokines (Interleukin-6) in this sample, but adjusting for this effect did not alter the associations with vegetarian diet. Conclusions: Plant-based eating as practiced by US-based Hispanic/Latino Seventh-day Adventists is associated with BMI in the recommended range. Further work is needed to characterize this type of diet for use in obesity-related interventions among Hispanic/Latinos in the US.

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Section: Discussionmentioning

confidence: 99%

Plant-Based Diets Are Associated With Lower Adiposity Levels Among Hispanic/Latino Adults in the Adventist Multi-Ethnic Nutrition (AMEN) Study

et al. 2019

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“…Several authors have demonstrated that carrying the IL-6 rs1800795 G or IL-6 rs1800795 G alleles is associated with higher IL-6 protein production (19)(20)(21). Specifically, IL-6 is a cytokine which is considered a prognostic marker as well as a potential therapeutic target for BC patients.…”

Section: Discussionmentioning

confidence: 99%

“…Common polymorphisms in proinflammatory and proangiogenic cytokine genes may influence their coded protein production and play a role in the course of BC. The polymorphisms with proved functional activity are VEGFA (rs699947, rs833061, rs25648, rs1005230), IL-1β (rs1143634, rs16944), IL-1α (rs1800587) and IL-6 (rs1800795, rs1800797) (14)(15)(16)(17)(18)(19)(20)(21). Candidate gene studies as well as moderate-sized genome-wide association studies (GWAS) highlight the important role of these polymorphisms in BC risk and aggressiveness (22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32), although substantial heterogeneity across studies exists.…”

Section: Association Of Angiogenesis and Inflammation-related Gene Fumentioning

confidence: 99%

Association of angiogenesis and inflammation‑related gene functional polymorphisms with early‑stage breast cancer prognosis

et al. 2020

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Genetic variations in inflammation-and angiogenesis-related genes may alter the coded protein level and impact the pathogenesis of breast cancer (BC). The present study investigated the association of functional single nucleotide polymorphisms (SNPs) in the VEGFA, IL-1β, IL-1α and IL-6 genes with the early-stage BC phenotype and survival. Genomic DNA and clinical data were collected for 202 adult Eastern European (Lithuanian) women with primary I-II stage BC. Genotyping of the SNPs was performed using TaqMan SNP genotyping assays. Nine VEGFA, IL-1β, IL-1α and IL-6 polymorphisms were analysed. The VEGFA and IL-6 haplotypes were inferred using Phase software. Patients were prospectively followed-up for recurrence, occurrence of metastasis and mortality until April 30, 2019. All studied genotypes were in Hardy-Weinberg equilibrium and had the same distribution as the 1,000 Genomes project Phase 3 dataset for European population. Significant associations of the studied SNPs with clinicopathologic variables were observed between IL-1α rs1800587 C allele and larger primary tumour size; IL-6 rs1800797 A allele, rs1800797 GA genotype, rs1800795 C allele, IL-6 (rs1800797-re1800795) AC diplotype and hormonal receptor-positive disease; IL-6 rs1800797 A allele and HER2 negative status. In univariate Cox survival analysis, IL-1α rs1800587 CC and IL-6 rs1800797 GG genotype carriers exhibited worse disease-free survival (DFS), metastasis-free survival (MFS) and overall survival (OS). The IL-6 rs1800795 GG genotype was associated with worse OS. IL-6 (rs1800797, rs1800795) GG/GG diplotype carriers had shorter MFS and OS. Multivariate Cox survival analysis revealed that the IL-1α rs1800587 CC genotype was an independent negative prognostic factor for DFS, MFS and OS, and the IL6 GG/GG diplotype was an independent negative prognostic factor for MFS and OS. According to the present study, functional SNPs in the IL-1α and IL-6 genes may contribute to the identification of patients at higher risk of BC recurrence, development of metastases and worse OS among early-stage patients with BC.

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“…The validity and reliability of this questionnaire among Malaysian have been assessed previously [38]. Nutrients data (protein, phosphorus, potassium, magnesium and calcium) were then analysed using Nutritionist Pro™ Diet Analysis Candidate genes and SNPs were chosen from previously published literature which showed associations with metabolic traits [12,15,16,22,[40][41][42][43]. IGF1 (rs35767, rs7136446) and IL6 gene (rs1800796) polymorphisms were selected in this study.…”

Section: Estimation Of Dietary Acid Loadmentioning

confidence: 99%

“…The previous study has shown that IL6 gene -587 G/A polymorphism would increase the risk of T2DM in G allele carriers closed to 1.3 fold as compared to those with C allele [8]. The SNPs rs1800797 (-597 G/A), rs1800796 (-572 G/C) and rs1800795 (-174 G/C) that are located in the promoter region of IL6, on the other hand, were associated with obesity and metabolic traits in different ethnic groups [12]. The rs1800796 polymorphism was associated with high insulinogenic index in Danes [14], hyperglycaemia in Mexicans [15] and hypertension and obesity in Asians [16,17].…”

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confidence: 94%

Dietary Acid Load and Its Interaction With IGF1 and IL6 Polymorphisms on Metabolic Traits Among Postmenopausal Women

Lim¹,

Chan²,

Ramachandran³

et al. 2020

Preprint

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Background: Despite considerable work has been done to understand the underlying disease mechanisms by elucidating its genetic etiology, still the pathophysiology of the metabolic syndrome remains unclear. While numerous studies have shown that Insulin growth factors-1 (IGF1), Interleukin-6 (IL-6) gene polymorphisms and high dietary acid load (DAL) were related to undesirable profile of metabolic traits; it remains controversial whether DAL is associated with genetic polymorphisms or risk of metabolic traits. Thus, the objective of this study was to explore the effects of DAL, IGF1 and IL6 gene polymorphisms and their potential diet-gene interactions on metabolic traits. Methods: A total of 211 community-dwelling postmenopausal women were recruited. DAL was estimated using potential renal acid load (PRAL). Blood was drawn for biochemical parameters and DNA was extracted and Agena® MassARRAY was used for genotyping analysis to identify the signaling of IGF1 (rs35767, rs7136446) and IL6 (rs1800796) polymorphisms. Interactions between diet and genetic polymorphisms were assessed using hierarchical multiple linear regression analysis.Results: Mean age of respondents was 67 ± 6.7 years. A total of 68.2%, 59.2%, 49.3%, 23.2%, 23.2% and 10.9% had elevated systolic blood pressure (SBP), hyperglycemia, excessive waist circumference (WC), diastolic blood pressure (DBP), triglycerides (TG) and low high-density lipoprotein (HDL), respectively. DAL was positively associated with FBG (β = 0.147, p < 0.05) and there was significant interaction effect between DAL and IL6 with SBP (β = 0.19, p = 0.041). On the other hand, there were no significant main effects of DAL and single nucleotide polymorphisms (SNPs) (rs35767, rs7136446 and rs1800796) on SBP, DBP, WC, TG or HDL and cholesterol ratio. There were also no significant interaction effects between DAL and IGF1 SNPs (rs35767 and rs7136446) on SBP, DBP and FBG, TG, HDL and cholesterol ratio. Conclusion: These findings did not support the interaction effects between DAL and IGF1 and IL6 SNPs (s35767, rs7136446 and rs1800796) on metabolic traits, except for SBP. Besides, higher DAL was associated with higher FBG, allowing us to postulate high DAL is a potential risk factor for diabetes. Future research delineating foods that contribute to high DAL, and how IL6 gene polymorphism influences the association with DAL on hypertension are warranted.

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Association of interleukin‐6 polymorphisms with obesity or metabolic traits in young Mexican‐Americans

Cited by 26 publications

References 37 publications

Plant-Based Diets Are Associated With Lower Adiposity Levels Among Hispanic/Latino Adults in the Adventist Multi-Ethnic Nutrition (AMEN) Study

Plant-Based Diets Are Associated With Lower Adiposity Levels Among Hispanic/Latino Adults in the Adventist Multi-Ethnic Nutrition (AMEN) Study

Association of angiogenesis and inflammation‑related gene functional polymorphisms with early‑stage breast cancer prognosis

Dietary Acid Load and Its Interaction With IGF1 and IL6 Polymorphisms on Metabolic Traits Among Postmenopausal Women

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