Impact of Cyclodextrin in Drug Delivery System

Mohapatra, Somesh; Sapra, Oshin; Paroha, Shweta; Dubey, Rajesh Kumar

doi:10.1007/978-3-319-75190-0_10

Cited by 2 publications

(2 citation statements)

References 93 publications

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“…CD complexation leads to alterations in the physicochemical properties of guest molecules, such as solubility, chemical stability, dispersibility, flowability, wettability and dissolution rate. All these factors give to these complexes a considerable potential in sustainable agriculture (Mohapatra et al 2018). For instance, host molecules entrap hydrophobic pesticides inside their cavity and enhance their solubility, protect them from hydrolysis, reduce their volatility, and increase their bioavailability (Villaverde et al 2004(Villaverde et al ,2005Yanez et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Analytical and in silico study of the inclusion complexes between tropane alkaloids atropine and scopolamine with cyclodextrins

et al. 2021

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Datura stramonium L. (Solanaceae) possesses a rich tropane alkaloids (TAs) spectrum. The plant contains, in particular, the allelopathic compounds scopolamine and atropine, which are poorly soluble in water, thus limiting their use in agrochemical formulations as biocidal and deterrent agents against herbivore insects. The efficacy of the hydrophobic TAs extracts could be increased with the improvement of their dissolution/leaching properties. This is important for improving screening and test performance and for elucidating the activity of environmentally friendly agricultural approaches, with new perspectives for the production and use of those biodegradable insecticidal products. The present study explores the aspects of atropine and scopolamine complexation with cyclodextrin (CDs) through FT-IR and UV–Vis spectroscopies. In addition, the structures of the inclusion complex of atropine, scopolamine and β-CD have been investigated by molecular modeling techniques. The results obtained indicate that β-CDs are a promising carriers for improving the properties of TAs, therefore increasing their application potential in agrochemical formulations. Graphic abstract

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Section: Introductionmentioning

confidence: 99%

Analytical and in silico study of the inclusion complexes between tropane alkaloids atropine and scopolamine with cyclodextrins

et al. 2021

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“…Application of CDs as solubility enhancers for otherwise poorly soluble small molecules has also become common in the biochemical production processes for a long time (27)(28)(29). The first review of CDs in skin applications appeared in the early stages of CD industrialization, but only a few new CDs have been tried since then, and even fewer have become commercialized formulations (23,24,(30)(31)(32)(33)(34). Despite their high formulation potential, relatively easy toxicological studies, and early start of publication activity, the skin-related technical papers represent only a minority (≈ 7%) in all publications, even within the pharmaceutical and cosmetics subgroup.…”

Section: Introductionmentioning

confidence: 99%

Cyclodextrins in Skin Formulations and Transdermal Delivery

Jicsinszky

Cravotto

2020

J Skin Stem Cell

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This mini review aims to describe the main physicochemical properties and characteristics of cyclodextrin derivatives (CDs) having been used in various skin-related formulations over the last nearly 50 years. Due to many misunderstandings and inconsistent data on the Internet, the basic properties of CDs, water content, solubility properties, and maximum complexing capabilities are summarized. CDs are grouped by their solubility properties and briefly described by chemical synthesis to reveal the potential contaminants. Soluble and insoluble CD-based polymers are also discussed.

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Impact of Cyclodextrin in Drug Delivery System

Cited by 2 publications

References 93 publications

Analytical and in silico study of the inclusion complexes between tropane alkaloids atropine and scopolamine with cyclodextrins

Analytical and in silico study of the inclusion complexes between tropane alkaloids atropine and scopolamine with cyclodextrins

Cyclodextrins in Skin Formulations and Transdermal Delivery

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