Impact of COVID-19 on in-hospital cardiac arrest outcomes: An updated meta-analysis

Bielski, Karol; Makowska, Karolina; Makowski, Adam; Kopiec, Tomasz; Malecka, Mariola; Pruc, Michał; Rafique, Zubaid; Peacock, Frank; Denegri, Andrea; Szarpak, Łukasz

doi:10.5603/cj.a2021.0168

Cited by 6 publications

(8 citation statements)

References 37 publications

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“…Similar to our finding, in a meta-analysis by Bielski et al, subgroup analysis comparing ROSC between COVID-19 and non-COVID-19 patients found lower rate of ROSC in the COVID-19 population (33.9%) as compared to the non-COVID-19 patients (52.1%) [21]. A proportional prevalence meta-analysis including 4 studies and 943 IHCA patients with COVID-19 by Mir et al [22] reported a lower pooled prevalence of ROSC (39%) than our study (52.83%).…”

Section: Discussionsupporting

confidence: 92%

Outcome of In-Hospital Cardiac Arrest among Patients with COVID-19: A Systematic Review and Meta-Analysis

Shrestha

Sedhai

Dawadi

et al. 2023

JCM

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Background: Outcomes following in-hospital cardiac arrest (IHCA) in patients with COVID-19 have been reported by several small single-institutional studies; however, there are no large studies contrasting COVID-19 IHCA with non-COVID-19 IHCA. The objective of this study was to compare the outcomes following IHCA between COVID-19 and non-COVID-19 patients. Methods: We searched databases using predefined search terms and appropriate Boolean operators. All the relevant articles published till August 2022 were included in the analyses. The systematic review and meta-analysis were conducted as per Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. An odds ratio with a 95% confidence interval (CI) was used to measure effects. Results: Among 855 studies screened, 6 studies with 27,453 IHCA patients (63.84% male) with COVID-19 and 20,766 (59.7% male) without COVID-19 were included in the analysis. IHCA among patients with COVID-19 has lower odds of achieving return of spontaneous circulation (ROSC) (OR: 0.66, 95% CI: 0.62–0.70). Similarly, patients with COVID-19 have higher odds of 30-day mortality following IHCA (OR: 2.26, 95% CI: 2.08–2.45) and have 45% lower odds of cardiac arrest because of a shockable rhythm (OR: 0.55, 95% CI: 0.50–0.60) (9.59% vs. 16.39%). COVID-19 patients less commonly underwent targeted temperature management (TTM) or coronary angiography; however, they were more commonly intubated and on vasopressor therapy as compared to patients who did not have a COVID-19 infection. Conclusions: This meta-analysis showed that IHCA with COVID-19 has a higher mortality and lower rates of ROSC compared with non-COVID-19 IHCA. COVID-19 is an independent risk factor for poor outcomes in IHCA patients.

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Section: Discussionsupporting

confidence: 92%

Outcome of In-Hospital Cardiac Arrest among Patients with COVID-19: A Systematic Review and Meta-Analysis

Shrestha

Sedhai

Dawadi

et al. 2023

JCM

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“…if necessary. We performed a systematic assessment of bias in the included studies using the Cochrane criteria [ 22 ]. For this purpose, a tool for Risk Of Bias In Non-randomized Studies of Interventions (ROBINS-I) [ 23 ] was used.…”

Section: Methodsmentioning

confidence: 99%

Effect of Coronary Artery Disease on COVID-19—Prognosis and Risk Assessment: A Systematic Review and Meta-Analysis

Szarpak

Mierzejewska

Jurek

et al. 2022

Biology

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Coronary artery disease (CAD) is the leading cause of death worldwide. Patients with pre-existing CAD were shown to have a more severe course of COVID-19, but this association has not been clarified. We performed a meta-analysis to determine the association between CAD and COVID-19 outcomes. We searched Scopus, Medline (PubMed), Web of Science, Embase, and Cochrane databases up to November 2nd, 2021. There were 62 studies with a total population of 49,286 patients included in the meta-analysis. CAD occurrence in survivor vs. non-survivor groups varied and amounted to 9.2% vs. 22.9%, respectively (OR = 0.33; 95%CI: 0.29 to 0.39; I2 = 70%; p < 0.001). CAD was also associated with increased severity of COVID-19 disease and was (10.8% vs. 5.6%, respectively, for severe vs. non-severe groups (OR = 2.28; 95%CI: 1.59 to 3.27; I2 = 72%; p < 0.001). The role of history of CAD in mortality and severe condition in COVID-19 presents itself as prominent—although a risk of bias in retrospective trials needs to be assessed, in case of our meta-analysis the statistically significant results when it comes to higher mortality among patients with CAD compared to non-CAD patients, a more severe condition observed in patients with CAD, and a visibly more frequent admission to intensive care unit in patients with CAD, it seems that an incidence of cardiovascular events plays a role in COVID-19 prognosis.

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“… 49 In a meta-analysis of 3 studies of in-hospital cardiac arrest, SARS-CoV 2 infection was associated with lower rates of shockable rhythm (9.6% vs. 19.8%, p< 0.001), lower rates of ROSC (33.9% vs. 52.1%, p< 0.001), and higher 30-day mortality (77.2% vs. 59.7%, p=0.003). 50 …”

Section: Introductionmentioning

confidence: 99%

Impact of COVID-19 on Nonpulmonary Critical Illness

Pirzadeh

Prescott

2023

Clinics in Chest Medicine

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Impact of COVID-19 on in-hospital cardiac arrest outcomes: An updated meta-analysis

Cited by 6 publications

References 37 publications

Outcome of In-Hospital Cardiac Arrest among Patients with COVID-19: A Systematic Review and Meta-Analysis

Outcome of In-Hospital Cardiac Arrest among Patients with COVID-19: A Systematic Review and Meta-Analysis

Effect of Coronary Artery Disease on COVID-19—Prognosis and Risk Assessment: A Systematic Review and Meta-Analysis

Impact of COVID-19 on Nonpulmonary Critical Illness

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