Impact of COVID‐19 and other viruses on reproductive health

Batiha, Osamah; Al‐Deeb, Taghleb; Al‐zoubi, Esra’a; Alsharu, Emad

doi:10.1111/and.13791

Cited by 65 publications

(59 citation statements)

References 82 publications

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“…However, emerging evidence indicates the possibility of testicular damage due to SARS-CoV-2 infection, which in turn may compromise the fertility potential of such men. Both the reproductive and general well-being of patients infected by SARS-CoV-2 may be at risk, as large proportions of vulnerable men are of reproductive age [ 55 ]. Proper hormonal balance is an important prerequisite to male fertility potential as well as outcome.…”

Section: Sars-cov-2 and Male Fertilitymentioning

confidence: 99%

Viral pathogenesis of SARS-CoV-2 infection and male reproductive health

et al. 2021

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Coronavirus disease 2019 (COVID-19) has emerged as a new public health crisis, threatening almost all aspects of human life. Originating in bats, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is transmitted to humans through unknown intermediate hosts, where it is primarily known to cause pneumonia-like complications in the respiratory system. Organ-to-organ transmission has not been ruled out, thereby raising the possibility of the impact of SARS-CoV-2 infection on multiple organ systems. The male reproductive system has been hypothesized to be a potential target of SARS-CoV-2 infection, which is supported by some preliminary evidence. This may pose a global threat to male fertility potential, as men are more prone to SARS-CoV-2 infection than women, especially those of reproductive age. Preliminary reports have also indicated the possibility of sexual transmission of SARS-CoV-2. It may cause severe complications in infected couples. This review focuses on the pathophysiology of potential SARS-CoV-2 infection in the reproductive organs of males along with their invasion mechanisms. The risks of COVID-19 on male fertility as well as the differences in vulnerability to SARS-CoV-2 infection compared with females have also been highlighted.

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Section: Sars-cov-2 and Male Fertilitymentioning

confidence: 99%

Viral pathogenesis of SARS-CoV-2 infection and male reproductive health

et al. 2021

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“…As mentioned above, ACE2 has recently been demonstrated as a receptor in SARS-CoV-2 infection. On the one hand, as a pivotal role in the cardiovascular system by generating the vasoconstrictor peptide angiotensin II (Ang II), the metallopeptidase angiotensin-converting enzyme (ACE) is a constitutive product of adult-type leydig cells and the expression of ACE2 by leydig cells suggests a regulatory role for the enzyme in steroidogenesis via limiting testosterone inhibition by Ang II ( Batiha et al, 2020 ; Li et al, 2020; Muñoz et al, 2014, Reis et al, 2010, Verdecchia et al, 2020; Zou et al, 2020) . On the other hand, Reis’ study suggested that the testicular samples of infertile men with impaired spermatogenesis expressed ACE2 mRNA at lower concentrations than samples with full spermatogenesis ( Reis et al, 2010 ).…”

Section: Effect Of Sars-cov-2 On Male Reproductive Systemmentioning

confidence: 99%

Effect of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) on reproductive system

Wang

Qin

et al. 2021

Stem Cell Research

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Since the emergence of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in December 2019, it has rapidly spread across many countries and it has become a crucial global health concern. Furthermore, SARS-CoV-2 infection not only effect on respiratory system, but on reproductive system of human. However, there has been not any review described the transmission paths and effects of SARS-CoV-2 infection on human reproductive system, systematically. In order to describe the transmission paths of SARS-CoV-2, effect on the male/female reproductive system of SARS-CoV-2 and some successful prevention measures. We would like to review effect of SARS-CoV-2 on reproductive system. To conclude, SARS-CoV-2 infection might damage to male reproductive system via ACE2 receptor mediating and male patients were reportedly slightly more affected than women by SARS-CoV-2 infections .

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“…Cervical cancer caused by HPV majorly affects women compared to men (Bray et al 2018 ). However, it is reported that due to the presence of ACE-2 receptors on all testicular cells, similar to SARS-CoV-1 that causes male infertility, SARS-CoV-2 is expected to affect the spermatogenesis (Vishvkarma and Rajender 2020 ; Batiha et al 2020 ). Since cancer patients receiving chemotherapy are at high risk for COVID-19 disease due to immunosuppression, additional care is required for such patients (Zhang et al 2020a , b ; Dewan et al 2020 ).…”

Section: High Rates Of Malignancies Caused By Infectious Agents In Pomentioning

confidence: 99%

Cancer vs. SARS-CoV-2 induced inflammation, overlapping functions, and pharmacological targeting

Subbarao

2021

Inflammopharmacol

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Inflammation is an intrinsic defence mechanism triggered by the immune system against infection or injury. Chronic inflammation allows the host to recover or adapt through cellular and humoral responses, whereas acute inflammation leads to cytokine storms resulting in tissue damage. In this review, we present the overlapping outcomes of cancer inflammation with virus-induced inflammation. The study emphasises how anti-inflammatory drugs that work against cancer inflammation may work against the inflammation caused by the viral infection. It is established that the cytokine storm induced in response to SARS-CoV-2 infection contributes to disease-associated mortality. While cancer remains the second among the diseases associated with mortality worldwide, cancer patients' mortality rates are often observed upon extended periods after illness, usually ranging from months to years. However, the mortality rates associated with COVID-19 disease are robust. The cytokine storm induced by SARS-CoV-2 infection appeared to be responsible for the multi-organ failure and increased mortality rates. Since both cancer and COVID-19 disease share overlapping inflammatory mechanisms, repurposing some anticancer and anti-inflammatory drugs for COVID-19 may lower mortality rates. Here, we review some of these inflammatory mechanisms and propose some potential chemotherapeutic agents to intervene in them. We also discuss the repercussions of anti-inflammatory drugs such as glucocorticoids and hydroxychloroquine with zinc or antiviral drugs such as ivermectin and remdesivir against SARS-CoV-2 induced cytokine storm. In this review, we emphasise on various possibilities to reduce SARS-CoV-2 induced cytokine storm.

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Impact of COVID‐19 and other viruses on reproductive health

Cited by 65 publications

References 82 publications

Viral pathogenesis of SARS-CoV-2 infection and male reproductive health

Viral pathogenesis of SARS-CoV-2 infection and male reproductive health

Effect of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) on reproductive system

Cancer vs. SARS-CoV-2 induced inflammation, overlapping functions, and pharmacological targeting

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