Impact of copeptin on diagnosis of acute coronary syndrome

Sayed, Zeinab H. El; Mahmoud, Hala Abdallah; Shall, Layla Y. El; Sheshtawey, Fawzia A. El; Mabrouk, Mohamed

doi:10.1016/j.ejmhg.2014.02.005

Cited by 2 publications

(3 citation statements)

References 15 publications

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“…This was in agreement with studies by Folli et al and El Sayed et al13, 14 This result is attributed to two hypotheses; first, the stress hypothesis where Copeptin/AVP is a substantial part of the endocrine stress response. The second is the hemodynamic hypothesis where AMI results in hypotension leading to baroreceptor stimulation and finally secretion of Copeptin/AVP from the posterior pituitary gland 15, 16…”

Section: Discussionsupporting

confidence: 93%

“…These results may be due to partial occlusion in coronaries, therefore, there is a minimal oxygen supply and thus, there is no cardiac underfilling, thus, no baroreceptors stimulation leading to no release of Copeptin. 23 El Sayed et al 14 stated that UA is not accompanied by myocardial necrosis, thus, it does not cause enough endogenous stress for Copeptin release.…”

Section: Discussionmentioning

confidence: 99%

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Clinical role of serum Copeptin in acute coronary syndrome

Mahmoud

Shaaban

Ramzy

2018

The Egyptian Heart Journal

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ObjectiveTo assess the role of Copeptin in diagnosis of acute myocardial infarction in troponin-blind period.Subjects and methodsThis study was conducted on 40 patients who presented to emergency department complaining of chest pain and were highly suspicious to have acute cardiac ischemia, in addition to 10 subjects serving as a healthy control group. Blood samples were collected for determination of CK-MB, cTnI and Copeptin. These were measured twice (in patients’ group); at 3 h and then at 6–9 h from admission time.ResultsThe first sample revealed a non-significant difference between UA group and AMI group as regards CKMB and troponin, however, high significant difference was found as regards Copeptin (Z = 5.29, P < 0.001). Moreover, ROC curve analysis of serum Copeptin for discriminating AMI group from UA group in the first sample showed diagnostic sensitivity and specificity of 100%.In conclusionDetermination of copeptin in early diagnosis of AMI has diagnostic value being superior to a conventional cTn-I within the first three hours after acute chest pain.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Clinical role of serum Copeptin in acute coronary syndrome

Mahmoud

Shaaban

Ramzy

2018

The Egyptian Heart Journal

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“…Hence co-peptin levels help in prognostication of AMI patients. (11) It can also be stated that co-peptin can be regarded as an earlier biomarker of AMI before troponin levels are raised. (12).…”

Section: Discussionmentioning

confidence: 99%

Comparison of Co-Peptin, Heart Fatty Acid Binding Protein, Troponin-I and CK-MB Assays as Diagnostic Biomarkers in Patients with Myocardial Infarction

2016

IJSR

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Introduction: Coronary artery disease (CAD) is the biggest non-communicable epidemic facing the world today. Myocardial infarction is a common presentation with increased mortality if the diagnosis and subsequent management is not prompt. There is an urgent need to identify a biomarker or a battery of biomarkers which can help the clinician in early diagnosis with reasonable sensitivity and specificity. This study compared the efiicacy of co-peptin, heart fatty acid binding protein, troponin-I and CK-MB as diagnostic markers for myocardial infarction. Methods: The present study was undertaken with 60 acute myocardial infarction patients 60 age and gender matched healthy subjects in a tertiary care hospital. Co-peptin and Heart Fatty Acid Binding Protein levels were estimated by commercially available ELISA kits provided by DRG International, Germany. Troponin I levels were quantitated on automated electrochemiluminescence provided by Roche, Germany using commercially available kits. CK-MB was quantified on Beckmann Coulter AU400 using commercially available kit. Results: The serum levels of co-peptin, heart fatty acid binding protein, troponin-I and CK-MB were significantly higher in the cases as compared to controls. Maximum area under the curve is covered by Co-peptin and Troponin (p<0.001). Conclusions: Our study demonstrated that troponin I was the best marker for MI with the highest area under curve followed by co peptin and then HFABP.

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Impact of copeptin on diagnosis of acute coronary syndrome

Cited by 2 publications

References 15 publications

Clinical role of serum Copeptin in acute coronary syndrome

Clinical role of serum Copeptin in acute coronary syndrome

Comparison of Co-Peptin, Heart Fatty Acid Binding Protein, Troponin-I and CK-MB Assays as Diagnostic Biomarkers in Patients with Myocardial Infarction

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