Impact of continuous positive airway pressure therapy for nonalcoholic fatty liver disease in patients with obstructive sleep apnea

Hirono, Haruka; Watanabe, Kazuhiko; Hasegawa, Katsuhiko; Kohno, Masaki; Terai, Shuji; Ohkoshi, Shogo

doi:10.12998/wjcc.v9.i19.5112

Cited by 7 publications

(9 citation statements)

References 47 publications

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“…The levels of ALT and AST in the OSAHS group were higher than in the control group, which is consistent with previous studies. Atan Doğan's [ 8 ] study of 194 patients with OSAHS and 114 control subjects found that the ALT and AST levels also in patients with OSAHS were higher than in the control group ( p < 0.05). Qu Yinfei [ 9 ] found that the ALT, AST, and AHI levels of patients with OSAHS were positively correlated ( r = 0.293, p < 0.05 and r = 0.275, p < 0.05), and ALT levels were negatively correlated with LSaO 2 ( r = −0.240, p < 0.05), suggesting that as the severity of OSAHS increases, ALT and AST levels increase.…”

Section: Discussionmentioning

confidence: 99%

“…With the deepening of research, increasing numbers of studies have also found a correlation between OSAHS and liver and kidney function damage [ 5 , 6 ]. In addition, studies have shown that OSAHS is considered to be an independent risk factor for nonalcoholic fatty liver disease (NAFLD) [ 7 , 8 ]. Krolow GK assessed the severity of OSAHS and NAFLD.…”

Section: Introductionmentioning

confidence: 99%

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Changing Effects of Minimally Invasive Surgical Intervention on ALT, AST, and UA in Patients with Obstructive Sleep Apnea-Hypopnea Syndrome

Zhao

Liu

et al. 2022

International Journal of Clinical Practice

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Background. This study aims at exploring the effect of obstructive sleep apnea–hypopnea syndrome (OSAHS) on the liver and kidney function indexes of patients and analyze the changes in these indexes after minimally invasive surgery. Method. Patients with OSAHS (n = 51) who were diagnosed via polysomnography (PSG) and received minimally invasive surgery in the sleep disorders diagnosis and treatment center of the West China Fourth Hospital of Sichuan University from January 2017 to January 2019 were selected as test subjects and placed in the OSAHS group. At the same time, 79 healthy people with no snoring or breathing difficulties were selected from the medical examination center of the hospital as the control group (tested as normal by PSG). These two groups were used to compare the differences in the related indexes of serum liver and kidney function and evaluate the changes in sleep monitoring and related liver and kidney function indexes in patients with OSAHS after minimally invasive surgery. Results. The alanine aminotransferase (ALT), aspartate aminotransferase (AST), and uric acid (UA) levels were higher in the OSAHS group (48.98 ± 36.34, 28.88 ± 14.80, and 422.30 ± 98.65, respectively) than in the control group (21.91 ± 11.61, 22.18 ± 6.19, and 330.49 ± 64.45 and t = 6.514, 3.549, and 6.373, respectively; p < 0.05 ). Of the patients with OSAHS, 17 were followed up for one year. After minimally invasive surgery, ALT decreased from 44.29 ± 20.61 to 26.47 ± 9.91 (t = 4.395), AST decreased from 27.71 ± 8.32 to 21.82 ± 4.81 (t = 3.673), and UA decreased from 397.35 ± 92.14 umol/L to 362.94 ± 106.76 umol/L (t = 2.580), and these differences were statistically significant ( p < 0.05 ).The changes in ALT (r = −0.635) and AST (r = −0.504) were related to the difference in the lowest blood oxygen saturation ( p < 0.05 ), and the change in UA was related to the difference in the apnea–hypopnea index (r = −0.532, p < 0.05 ). Conclusion. There are some abnormalities in liver- and kidney-function-related indexes in patients with OSAHS, and minimally invasive surgery can help to improve liver and kidney function in these patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Changing Effects of Minimally Invasive Surgical Intervention on ALT, AST, and UA in Patients with Obstructive Sleep Apnea-Hypopnea Syndrome

Zhao

Liu

et al. 2022

International Journal of Clinical Practice

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“…The basic information about the attenuation parameter (CAP) using Fibroscan (p = 0.987). 6 A cohort retrospective study by Kim et al showed significant improvement in AST from 27.9 ± 15.9 to 24.9 ± 9.7 (p < 0.001; 95% CI: -4.67 to -1.43), ALT from 44.5 ± 22.3 to 39.1 ± 16.1 (p < 0.001; 95% CI: -7.61 to -3.33), and APRI from 0.35 ± 0.27 to 0.31 ± 0.18 (p = 0.004; 95% CI: -0.07 to -0.01). 2 This study also showed adequate adherence to CPAP as an independent predictor of NAFLD regression (OR = 3.93; 95% CI: 1.29-11.94).…”

Section: Data Collectionmentioning

confidence: 99%

“…1,5 OSA is a sleep disorder characterized by repetitive complete or partial obstruction of the upper airway, leading to chronic intermittent hypoxia, sleep fragmentation, and increased negative intrathoracic pressure. 6,7 OSA is a highly prevalent disease. It affects approximately 9% of middle-aged women and 24% of men.…”

Section: Introductionmentioning

confidence: 99%

“…CPAP therapy could decrease daytime sleepiness, hypoxic events, and ameliorate metabolic and cardiovascular diseases. 6,8 With the association of OSA and NAFLD, CPAP may give a potential therapeutic option for patients with NAFLD. However, it is still unclear whether CPAP treatment would modify the presence of NAFLD in patients with both NALFD and OSA.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Continuous Positive Airway Pressure on Nonalcoholic Fatty Liver Disease in Patients with Obstructive Sleep Apnea: A Systematic Review

Tamin

Ardiantara

Rudiatmoko

2023

InaJGHE

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Background: Nonalcoholic fatty liver disease (NAFLD) is associated with obstructive sleep apnea (OSA). Continuous positive airway pressure (CPAP) is the first-line therapy for OSA. However, the effect of CPAP on NAFLD in patients with concomitant OSA is still unclear. This study aims to identify the use of CPAP on NAFLD in patients with OSA. Method: A systematic literature search was performed using particular keywords and medical subheadings in three journal databases: Cochrane, PubMed, and EBSCOhost. The results were screened and assessed using inclusion and exclusion criteria by three independent authors. The Randomized controlled trial (RCT) quality was evaluated with Jadad scale and the cohort studies quality was assessed with Newcastle-Ottawa quality assessment scale.Results: Two RCTs and three cohort studies were eligible to fulfil the inclusion criteria, consisting of 620 total patients. Two RCTs showed no statistically significant improvement after CPAP treatment in NAFLD based on intrahepatic triglyceride (measured by proton magnetic resonance spectroscopy), liver stiffness measurement, serum cytokeratin-18 fragment, and liver function blood test parameters. Meanwhile, 2 cohort studies in adults and 1 cohort study in children showed significant improvement in ALT, AST, and APRI. However, one cohort study showed no significant improvement in serum fibrosis markers and transient elastography measurement after CPAP treatment.Conclusion: CPAP might be beneficial in some patients with OSA to improve NAFLD, but further research that includes many subjects and longer duration of CPAP therapy is needed to confirm this result.

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Evaluation of Hepatic Steatosis and Fibrosis Using Transient Elastography in Patients With Obstructive Sleep Apnea

Parchani,

Gupta,

Kant

et al. 2024

Journal of Clinical and Experimental Hepatology

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Impact of continuous positive airway pressure therapy for nonalcoholic fatty liver disease in patients with obstructive sleep apnea

Cited by 7 publications

References 47 publications

Changing Effects of Minimally Invasive Surgical Intervention on ALT, AST, and UA in Patients with Obstructive Sleep Apnea-Hypopnea Syndrome

Changing Effects of Minimally Invasive Surgical Intervention on ALT, AST, and UA in Patients with Obstructive Sleep Apnea-Hypopnea Syndrome

Effects of Continuous Positive Airway Pressure on Nonalcoholic Fatty Liver Disease in Patients with Obstructive Sleep Apnea: A Systematic Review

Evaluation of Hepatic Steatosis and Fibrosis Using Transient Elastography in Patients With Obstructive Sleep Apnea

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