Impact of Clinical Association Between Gout and Dementia: A Nationwide <scp>Population‐Based</scp> Cohort Study in Korea

Kim, Ji Hyoun; Yim, Dong‐Hyuk; Choi, In Ah; Lee, Jeonghwan; Park, Hyemi; Eom, Sang‐Yong

doi:10.1002/acr.24959

Cited by 6 publications

(16 citation statements)

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“…On the other hand, after adjusting for age and sex, the risk for vascular dementia in gout patients increased by approximately 2.3 times in non-elderly men. In this study, the association between gout and dementia showed different results according to age or type of dementia [40]. Studies on the association between gout or hyperuricemia and Parkinson's disease have also yielded conflicting results.…”

Section: Clinical Association Between Gout or Hyperuricemia And Neuro...mentioning

confidence: 65%

“…Risk of dementia, especially vascular or mixed dementia, may be increased with high SUA levels in elderly people [37]. Few studies have explored the association between gout or hyperuricemia and neurodegenerative diseases in Korea [39,40]. In a retrospective cohort study using Korea NHIS data, gout has been shown to be inversely related to the risk for overall dementia, especially in elderly men.…”

Section: Clinical Association Between Gout or Hyperuricemia And Neuro...mentioning

confidence: 99%

“…Many studies have been reported on the impact of SUA on various diseases [33][34][35][36][37][38][39][40][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58]. For example, higher SUA levels were related to a reduced risk for lower urinary tract symptoms and was positively associated with lung function among clinically healthy middle-aged men [49,53].…”

Section: Other Disease Associations With Hyperuricemiamentioning

confidence: 99%

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Epidemiology and treatment-related concerns of gout and hyperuricemia in Korean

Ahn

2023

J Rheum Dis

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Gout is the most common form of inflammatory arthritis that affects mainly middle-aged men, and there is clear evidence of an association between hyperuricemia and the risk for gout. Increasing prevalence of gout and hyperuricemia has been reported in many countries. The prevalence of gout and hyperuricemia are constantly increasing in Korea with the patients at risk for developing a variety of comorbidities. Although there have been studies on the association between gout or serum uric acid level and several neurodegenerative diseases, cancer, and cardiovascular mortality, the causal relationship between gout and these comorbidities are still unclear. The associations of substantial economic burden with hyperuricemia, gout attack, and suboptimal treatment are well known. Gout is a disease that requires lifelong management including lifestyle modification. However, gout is poorly managed worldwide although effective urate-lowering drugs exist. In this review, we addressed epidemiological studies and treatment-related problems in the Korean population with gout or hyperuricemia to obtain the best clinical outcomes and reduce their medical burden.

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Section: Clinical Association Between Gout or Hyperuricemia And Neuro...mentioning

confidence: 65%

Section: Clinical Association Between Gout or Hyperuricemia And Neuro...mentioning

confidence: 99%

Section: Other Disease Associations With Hyperuricemiamentioning

confidence: 99%

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Epidemiology and treatment-related concerns of gout and hyperuricemia in Korean

Ahn

2023

J Rheum Dis

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“…An important mechanism may be the pro-and antioxidant effects of uric acid. Uric acid is an important circulating antioxidant and free radical scavenger, which can scavenge peroxynitrite and hydroxyl radicals and reduce oxidative stress, thereby exerting neuroprotective effects (Kanellis and Kang, 2005;Lee et al, 2022). In addition, uric acid may preserve mitochondrial function and inhibit the accumulation of oxygen-free radicals, and mitochondrial dysfunction is considered to be one of the pathogeneses of AD (Yu et al, 1998;Ye et al, 2016).…”

Section: Interpretation Of Findingsmentioning

confidence: 99%

“…A prospective cohort study of 375,894 individuals showed that immune-mediated disorders were significantly associated with an increased risk of dementia (Zhang et al, 2022 ). In addition, several observational studies have reported that gout and hyperuricemia might increase the risk of dementia, although the conclusions of different studies are inconsistent (Hong et al, 2015 ; Lu et al, 2016 ; Singh and Cleveland, 2018 ; Chuang et al, 2021 ; Mikhailichenko et al, 2021 ; Min et al, 2021 ; Dehlin et al, 2022 ; Kim et al, 2022 ). One recent meta-analysis on a similar topic has been published.…”

Section: Introductionmentioning

confidence: 99%

Gout and risk of dementia, Alzheimer's disease or vascular dementia: a meta-epidemiology study

Huang

Tang

et al. 2023

Front. Aging Neurosci.

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ObjectivesThe association between gout and dementia, Alzheimer's disease (AD), or vascular dementia (VD) is not fully understood. The aim of this meta-analysis was to evaluate the risk of all-cause dementia, AD, and VD in gout patients with or without medication.MethodsData sources were PubMed, Embase, the Cochrane Library, and reference lists of included studies. This meta-analysis included cohort studies assessing whether the risk of all-cause dementia, AD, and VD was associated with gout. The risk of bias was assessed using the Newcastle-Ottawa Quality Assessment Scale (NOS). The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system was used to access the overall certainty of evidence. Risk ratios (RR) with 95% confidence intervals (CI) were pooled using a random-effects model, and publication bias was assessed with funnel plots and Egger's test.ResultsA total of six cohort studies involving 2,349,605 individuals were included in this meta-analysis, which were published between 2015 and 2022. The pooling analysis shows that the risk of all-cause dementia was decreased in gout patients [RR = 0.67, 95% CI (0.51, 0.89), I2 = 99%, P = 0.005, very low quality], especially in gout patients with medication [RR = 0.50, 95% CI (0.31, 0.79), I2 = 93%, P = 0.003, low quality]. The risk of AD [RR = 0.70, 95% CI (0.63, 0.79), I2 = 57.2%, P = 0.000, very low quality] and VD [RR = 0.68, 95% CI (0.49, 0.95), I2 = 91.2%, P = 0.025, very low quality] was also decreased in gout patients. Despite the large heterogeneity, the sensitivity analysis indicated that the results were robust, and there was little evidence of publication bias.ConclusionThe risk of all-cause dementia, AD, and VD is decreased in gout patients, but the quality of evidence is generally low. More studies are still needed to validate and explore the mechanisms of this association.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/#recordDetails, identifier: CRD42022353312.

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Gout/hyperuricemia reduces the risk of Alzheimer's disease: A meta‐analysis based on latest evidence

Wang,

Tan,

Wang

et al. 2023

Brain and Behavior

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ObjectivePrevious studies have found the potential role of gout or hyperuricemia in subsequent development of Alzheimer's disease (AD) but reported inconsistent results. We conducted the current meta‐analysis to evaluate whether an association exists between gout/ hyperuricemia and AD.MethodsWe systematically searched PubMed and EMBASE for the published cohort studies that measured the risk of AD in subject with gout/ hyperuricemia up to May 20, 2023. Data extraction was employed by two authors independently. Rev Man 5.3 and Stata 15.0 software were used to calculate the relative ratio (RR) or hazard ratio (HR) for including studies. Subgroup analysis was performed to assess the sources of heterogeneity. A random‐effects model was adopted when heterogeneity was present. The funnel plot, Begg's test, and and Egger's test were used to assess publication bias.ResultsAfter rigorous screening, seven eligible studies were included in the final analyses. Pooled results indicated that gout or hyperuricemia decreases the risk of AD (RR: 0.69, 95% CI: 0.64∼0.72), with a high heterogeneity of 93%. Subgroup analyses showed that regional distribution was the source of heterogeneity. Egger's and Begg's tests as well as visual inspection of funnel plot suggested no publication bias in the studies.ConclusionThe findings suggested that gout or hyperuricemia might have a protective effect against AD. This negative correlation should be verified by more cohort studies due to the existence of substantial heterogeneity.

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Impact of Clinical Association Between Gout and Dementia: A Nationwide Population‐Based Cohort Study in Korea

Cited by 6 publications

References 52 publications

Epidemiology and treatment-related concerns of gout and hyperuricemia in Korean

Epidemiology and treatment-related concerns of gout and hyperuricemia in Korean

Gout and risk of dementia, Alzheimer's disease or vascular dementia: a meta-epidemiology study

Gout/hyperuricemia reduces the risk of Alzheimer's disease: A meta‐analysis based on latest evidence

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