Impact of Chronic Kidney Disease on Major Bleeding Complications and Mortality in Patients With Indication for Oral Anticoagulation Undergoing Coronary Stenting

Manzano‐Fernández, Sergio; Marı́n, Francisco; Pastor‐Pérez, Francisco J.; Caro, César; Cambronero, Francisco; Lacunza, Javier; Pinar, Eduardo; Pascual-Figal, Domingo A.; Valdés, Mariano; Lip, Gregory Y.H.

doi:10.1378/chest.08-1425

Cited by 19 publications

(16 citation statements)

References 22 publications

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“…Although a systematic review identified the following patient characteristics as risk factors for anticoagulationrelated bleeding complications-advanced age, uncontrolled hypertension, history of ischemic heart disease, cerebrovascular disease, anemia or a history of bleeding, and the concomitant use of other drugs such as antiplatelet agents (42)-our study only identified a history of bleeding as an independent risk factor. Renal impairment has not been previously reported to be a risk factor for bleeding in AF (42), except for patients undergoing coronary stenting (43). We found that the new HAS-BLED scheme was predictive of subsequent bleeding events, even remaining significant after multivariate analysis of plasma vWF levels.…”

Section: Discussionmentioning

confidence: 49%

Plasma von Willebrand Factor Levels Are an Independent Risk Factor for Adverse Events Including Mortality and Major Bleeding in Anticoagulated Atrial Fibrillation Patients

Roldán

Marı́n

Muiña

et al. 2011

Journal of the American College of Cardiology

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114

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Section: Discussionmentioning

confidence: 49%

Plasma von Willebrand Factor Levels Are an Independent Risk Factor for Adverse Events Including Mortality and Major Bleeding in Anticoagulated Atrial Fibrillation Patients

Roldán

Marı́n

Muiña

et al. 2011

Journal of the American College of Cardiology

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114

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“…There is growing evidence for an association between chronic kidney disease (CKD) and adverse cardiovascular events [4,5,6]. CKD is associated also with increased risk of bleeding after coronary interventions [7,8,9], acute myocardial infarction [10], coronary artery bypass surgery [11] and use of anticoagulation [12], as well as with cerebral small-vessel disease, white matter hyperintensities and microbleeds [13,14,15,16]. We have, therefore, hypothesized that in the setting of ICH, CKD is associated with larger initial hematoma volume and poor outcome.…”

Section: Introductionmentioning

confidence: 99%

Chronic Kidney Disease in Patients with Acute Intracerebral Hemorrhage: Association with Large Hematoma Volume and Poor Outcome

Molshatzki

Orion²,

Tsabari³

et al. 2010

Cerebrovasc Dis

101

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Background: Chronic kidney disease (CKD) is associated with both a risk of adverse vascular outcome and a risk of bleeding. We have tested the hypothesis that in the setting of an acute intracerebral hemorrhage (ICH), CKD is associated with poor outcome and with larger hematoma volume. Methods: We examined the association between CKD and ICH characteristics and outcome within a prospective cohort study of consecutive patients hospitalized with an acute stroke and followed for 1 year. CKD was categorized by the estimated baseline glomerular filtration rate into moderate/severe impairment (<45), mild impairment (45–60) and no impairment (>60 ml/min/1.73 m²). Results: Among 128 patients with an ICH (mean age = 71.7 ± 12.3 years, 41.4% women) 46.1% had CKD (23.4% mild and 22.7% moderate/severe). Patients with moderate/severe impairment had >4-fold adjusted hazard ratio for mortality over 1 year (4.29; 95% CI = 1.69–10.90) compared to patients with no impairment. The hematoma volumes [median (25–75%)] were 15.3 ml (5.4–37.5) in patients with no impairment, 16.6 (6.8–36.9) in mild impairment and 50.2 (10.4–109.1) in moderate/severe impairment (p = 0.009). The location of the hematoma was lobar in 12% with no impairment, 17% with mild impairment and 39% with moderate/severe impairment (p = 0.02). Patients with moderate/severe impairment exhibited a 2.3-fold higher hematoma volume (p = 0.04) and a >6-fold higher odds of lobar location (95% CI = 1.59–24.02) as compared to no impairment. Further adjustment for antiplatelet use and for presence of leukoaraiosis attenuated the association with hematoma volume (p = 0.15), while moderate/severe impairment was associated with an adjusted OR of 5.35 (95% CI = 1.18–24.14) for lobar location. Conclusions: Presence of moderate/severe CKD among patients with ICH is associated with larger, lobar hematomas and with poor outcome.

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“…Chronic kidney disease (CKD) is a growing problem and brings an increased risk of cardiovascular disease [24]. The best renal function tests are undoubtedly urea and creatinine, the latter generating an estimated glomerular filtration rate (eGFR).…”

Section: Haematologymentioning

confidence: 99%

British Journal of Biomedical Science in 2016. What have we learned?

Blann

2017

British Journal of Biomedical Science

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In 2016, the British Journal of Biomedical Science published 36 reports outlining specific advances in each of the various disciplines within biomedical science. These were one review, 25 original articles, 9 'In Brief' reports and one letter to the Editor. Of these, the majority were in blood science (5 in biochemistry, 7 in haematology and 2 in immunology) and infection science (8 in microbiology, 2 in virology) with a smaller number in cellular sciences (6 in cellular pathology and 2 in cytopathology). Three reports considered both biochemistry and immunology, while another reported an advance in the identification of chromosomal abnormalities. The present report will summarise key aspects of these publications that are of greatest relevance to laboratory scientists.

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Impact of Chronic Kidney Disease on Major Bleeding Complications and Mortality in Patients With Indication for Oral Anticoagulation Undergoing Coronary Stenting

Cited by 19 publications

References 22 publications

Plasma von Willebrand Factor Levels Are an Independent Risk Factor for Adverse Events Including Mortality and Major Bleeding in Anticoagulated Atrial Fibrillation Patients

Plasma von Willebrand Factor Levels Are an Independent Risk Factor for Adverse Events Including Mortality and Major Bleeding in Anticoagulated Atrial Fibrillation Patients

Chronic Kidney Disease in Patients with Acute Intracerebral Hemorrhage: Association with Large Hematoma Volume and Poor Outcome

British Journal of Biomedical Science in 2016. What have we learned?

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