Impact of chronic exposure of rainbow trout, Oncorhynchus mykiss, to low doses of glyphosate or glyphosate-based herbicides

Du-Carrée, Jessy Le; Danion, Morgane

doi:10.1016/j.aquatox.2020.105687

Cited by 20 publications

(13 citation statements)

References 81 publications

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“…Limits for the presence of GLY in drinking water range from the highest levels in Australia (1000 µg/L) and USA (700 µg/L) to lower levels in Canada (280 µg/L) and Europe (0.1 µg/L) [ 2 ]. Despite the claim that GLY-based herbicides only target plant-specific enzymatic pathway, various studies demonstrated adverse effects of this contaminant in both vertebrate and invertebrates [ 3 , 4 , 5 ], as well as in wildlife and aquatic species [ 6 , 7 , 8 , 9 , 10 ], where this contaminant, alone or in formulation, induced oxidative stress and DNA damage. These observations are raising concern about public health since GLY can be detected in the urine of humans [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Metabolomic and Transcript Analysis Revealed a Sex-Specific Effect of Glyphosate in Zebrafish Liver

Giommi

Ladisa

Carnevali

et al. 2022

IJMS

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Glyphosate is a component of commonly used herbicides for controlling weeds in crops, gardens and municipal parks. There is increasing awareness that glyphosate-based herbicides, in addition to acting on plants, may also exert toxicity in wildlife and humans. In this study, male and female adult zebrafish were exposed to 700 µg/L of glyphosate (GLY), for 28 days. We used the metabolomic approach and UHPLC-ESI-MS to analyze liver samples to investigate the adverse effects of glyphosate on hepatic metabolism. The impact of GLY was found to be sex-specific. In female, GLY exposure affected purine metabolism by decreasing the levels of AMP, GMP and inosinic acid, consequently increasing uric acid levels with respect to the control (CTRL). Exposure to GLY also caused a decrease of UMP levels in the pyrimidine metabolism pathway. In male, GLY exposure decreased the aminoadipic acid within the lysine degradation pathway. Transcript analysis of genes involved in stress response, oxidative stress and the immune system were also performed. Results demonstrated an increased stress response in both sexes, as suggested by higher nr3c1 expression. However, the hsp70.2 transcript level was increased in female but decreased in male. The results demonstrated reduced sod1, sod2, and gpx1a in male following exposure to GLY, indicating an impaired oxidative stress response. At the same time, an increase in the cat transcript level in female was observed. mRNA levels of the pro-inflammatory interleukins litaf and cxcl8b.1 were increased in female. Taken together, the results provide evidence of disrupted nucleotide hepatic metabolism, increased stress inflammatory response in female and disruption of oxidative stress response in male.

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Section: Introductionmentioning

confidence: 99%

Metabolomic and Transcript Analysis Revealed a Sex-Specific Effect of Glyphosate in Zebrafish Liver

Giommi

Ladisa

Carnevali

et al. 2022

IJMS

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“…There are just a few data about the chronic effects of glyphosate on nontarget organisms. For example, Le Du-Carrée [75] have studied chronic exposure to glyphosate with a concentration of 1 µg/L on rainbow trout for 10 months. No significant changes in reproduction, metabolism, nor even oxidative response were observed.…”

Section: Toxic Effects 231 Fishmentioning

confidence: 99%

Effects of Glyphosate and Its Metabolite AMPA on Aquatic Organisms

2021

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Glyphosate (N-(phosphonomethyl)glycine) was developed in the early 1970s and at present is used as a herbicide to kill broadleaf weeds and grass. The widely occurring degradation product aminomethylphosphonic acid (AMPA) is a result of glyphosate and amino-polyphosphonate degradation. The massive use of the parent compound leads to the ubiquity of AMPA in the environment, and particularly in water. Considering this, it can be assumed that glyphosate and its major metabolites could pose a potential risk to aquatic organisms. This review summarizes current knowledge about residual glyphosate and its major metabolite AMPA in the aquatic environment, including its status and toxic effects in aquatic organisms, mainly fish. Based on the above, we identify major gaps in the current knowledge and some directions for future research knowledge about the effects of worldwide use of herbicide glyphosate and its major metabolite AMPA. The toxic effect of glyphosate and its major metabolite AMPA has mainly influenced growth, early development, oxidative stress biomarkers, antioxidant enzymes, haematological, and biochemical plasma indices and also caused histopathological changes in aquatic organisms.

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“…There are just several data about the chronic effects of glyphosate on non-target organisms. For example, [74] studied chronic exposure to glyphosate with a concentration of 1 μg/L on rainbow trout for 10 months. No significant changes in reproduction, metabolism, nor even oxidative response were observed.…”

Section: Toxic Effectsmentioning

confidence: 99%

Effects of Glyphosate and Their Metabolite AMPA on Aquatic Organisms

Tresnakova¹,

Stará²,

Velíšek³

2021

Preprint

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Glyphosate (N-(phosphonomethyl)glycine) is a herbicide used to kill broadleaf weeds and grass, developed in the early 1970s. The widely occurring degradation product aminomethylphosphonic acid (AMPA) is a result of glyphosate and amino-polyphosphonate degradation. The massive use of the parent compounds leads to the ubiquity of AMPA in the environment, and particularly in water. Considering this, it can be assumed that glyphosate and its major metabolites could pose a potential risk to aquatic organisms. This review summarises current knowledge about residual glyphosate and their major metabolite AMPA in the aquatic environment, including status and toxic effects in aquatic organisms, mainly fish, are reviewed. Based on the above, we identify major gaps in the current knowledge and some directions for future research knowledge about the effects of worldwide use of herbicide glyphosate and its major metabolite AMPA. The toxic effect of glyphosate and their major metabolite AMPA has mainly influenced growth, early development, oxidative stress biomarkers, antioxidant enzymes, haematological, biochemical plasma indices, caused histopathological changes in the aquatic organism.

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Impact of chronic exposure of rainbow trout, Oncorhynchus mykiss, to low doses of glyphosate or glyphosate-based herbicides

Cited by 20 publications

References 81 publications

Metabolomic and Transcript Analysis Revealed a Sex-Specific Effect of Glyphosate in Zebrafish Liver

Metabolomic and Transcript Analysis Revealed a Sex-Specific Effect of Glyphosate in Zebrafish Liver

Effects of Glyphosate and Its Metabolite AMPA on Aquatic Organisms

Effects of Glyphosate and Their Metabolite AMPA on Aquatic Organisms

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