Impact of Brazil Nut (<i>Bertholletia excelsa</i>, H.B.K.) Supplementation on Body Composition, Blood Pressure, and the Vascular Reactivity of Wistar Rats When Submitted to a Hypersodium Diet

Melo, Henrique Saldanha; Monnerat, Juliana Arruda de Souza; Costa, Nathalia da Silva; Bernardes, Thais Bento; Magliano, D’Angelo Carlo; Pereira, Aline D'Avila; Almeida, Patrícia Pereira; Lima, Gabriel Ferreira; Brito, Fernanda; Pinto, Milena; Kindlovits, Raquel; Nogueira, Anna Beatriz; Sepúlveda-Fragoso, Vinícius; Nóbrega, Antônio Cláudio Lucas da; Motta, Nadia Alice Vieira; Medeiros, Renata Jurema

doi:10.1080/07315724.2021.1925995

Cited by 4 publications

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“…To the best of our knowledge, this is the first study that used BN as a supplement in healthy rats to evaluate its effects on the above parameters. The potential of BN supplementation as a therapeutic strategy for chronic diseases was previously demonstrated by experimental studies and clinical trials (Almeida et al, 2020; Kume et al, 2021; Macan et al, 2020; Saldanha Melo et al, 2021; Stockler‐Pinto et al, 2014, 2015). In this study, 5% BN supplementation increased HDL‐c levels and improved lipid peroxidation and bone parameters.…”

Section: Discussionmentioning

confidence: 89%

Supplementation of diet with Brazil nut modulates body composition, bone parameters, and lipid peroxidation in Wistar rats

Costa

Almeida

Cruz

et al. 2022

Journal of Food Biochemistry

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Oxidative stress, adipose tissue, and bone compartments can be disturbed in chronic diseases. Non‐pharmacological strategies, such as Brazil nuts (BNs), can improve these parameters. This study evaluated the effects of BN supplementation at different concentrations on body composition, lipid profile, and peroxidation in healthy rats. Male Wistar rats were divided into three groups: control (CT), Brazil nut 5% (BN5), and Brazil nut 10% (BN10) groups. Body composition, brown adipose tissue (BAT), plasma lipid peroxidation, and lipid profile were evaluated in the three groups. The BN5 group showed an improvement in all bone parameters compared with that of the CT group (p < .0001). The BN5 and BN10 groups showed reduced plasma lipid peroxidation compared with that of the CT group (p = .0009), whereas the BN10 group presented lower BAT lipid peroxidation than that of the other groups (p = .01). High‐density lipoprotein‐cholesterol (HDL‐c) levels were higher in the BN5 group than in the CT group (p = .01). Conclusively, the use of BNs in a controlled manner promoted improvement in bone parameters, HDL‐c levels, and lipid peroxidation in healthy rats. Practical applications Nuts has been included in the diet because of their versatility, acceptance, and easy access. Among them, Brazil nut (BN) is considered one of the major known food sources of selenium as well as a source of fibers, unsaturated fatty acids, and phenolic compounds. Studies have shown that BN supplementation is effective in reducing oxidative stress, inflammation, lipid peroxidation, and selenium deficiency when used as a non‐pharmacological strategy in experimental models of chronic diseases and in clinical trials. The present study showed that controlled administration of BN improved bone parameters, high‐density lipoprotein‐cholesterol levels, and lipid peroxidation in healthy rats. Therefore, BN is a promising non‐pharmacological agent for the prevention of the onset of chronic non‐communicable diseases.

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