Impact of blood pressure, cholesterol and glucose in the association between adiposity measures and coronary heart disease and stroke among Iranian population

Boloukat, Reyhaneh Rajab; Ramezankhani, Azra; Hasheminia, Mitra; Tasdighi, Erfan; Azizi, Fereidoun; Hadaegh, Farzad

doi:10.1016/j.clnu.2017.09.023

Cited by 15 publications

(10 citation statements)

References 32 publications

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“…Therefore, it is necessary to identify the relevant risk factors for CIMT to facilitate the early comprehensive prevention and treatment of macroangiopathy. According to previous studies, CIMT can be affected by many factors, including age [16][17][18], sex [16][17][18], smoking [19,20], blood pressure [21], blood lipid levels [22], thyroid function [23,24], blood glucose levels [25], blood glucose level fluctuations, and C-peptide levels [26,27].…”

Section: Introductionmentioning

confidence: 99%

Analysis of risk factors for carotid intima-media thickness in patients with type 2 diabetes mellitus in Western China assessed by logistic regression combined with a decision tree model

Zhou

Qiu

Yang

et al. 2020

Diabetol Metab Syndr

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Background: Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in patients with type 2 diabetes (T2DM). Carotid intima-media thickness (CIMT) is considered a preclinical stage of atherosclerosis. Therefore, it is necessary to identify the related risk factors for CIMT to facilitate the early prevention of CVD. Previous studies have shown that visceral fat area (VFA) is a risk factor for T2DM and CVD. However, few studies have focused on the effects of VFA on CIMT associated with T2DM. Moreover, considering that the body fat distribution shows regional and racial heterogeneity, the purpose of this study was to investigate the predictive value of VFA and other risk factors for CIMT associated with T2DM in Western China. Methods: In a cross-sectional study, a total of 1372 patients with T2DM were divided into the CIMT (−) group (n = 965) and the CIMT (+) group (n = 407) based on CIMT values. In addition to the univariate analyses, logistic regression analysis and a decision tree model were simultaneously performed to establish a correlation factor model for CIMT. Results: Univariate analyses showed that sex, smoking status, age, heart rate, systolic blood pressure (SBP), diastolic blood pressure (DBP), height, weight, body mass index (BMI), waist circumference, hip circumference, waist-hip ratio, VFA, subcutaneous fat area, and the levels of 2-h C-peptide, serum creatinine, urea nitrogen and uric acid were significantly different between the two groups (all p < 0.05). Smoking, increased VFA, female sex and increased BMI were risk factors in the logistic regression analyses (OR = 5.759, OR = 1.364, OR = 2.239, OR = 1.186, respectively). In the decision tree model, smoking was the root node, followed by sex, waist circumference, VFA and chronic kidney disease (CKD) in order of importance. Conclusions: In addition to smoking, sex and BMI, VFA has a significant effect on CIMT associated with T2DM in the Chinese Han population in Western China. In addition, the decision tree model could help clinicians make more effective decisions, with its simplicity and intuitiveness, making it worth promoting in future medical research.

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Section: Introductionmentioning

confidence: 99%

Analysis of risk factors for carotid intima-media thickness in patients with type 2 diabetes mellitus in Western China assessed by logistic regression combined with a decision tree model

Zhou

Qiu

Yang

et al. 2020

Diabetol Metab Syndr

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“…Several factors have been implicated in the development of stroke associated pneumonia, which include DM, smoking, Hypertension, COPD, Dyslipidemia, Chronic atrial fibrillation and impaired swallowing. [11][12][13][14][15][16] In my study hypertension was the most common factors found in patients with stroke associated pneumonia. Frequency of hypertension was 84.8%, this is in contrast to western data in which hypertension was found in only 28.4%.…”

Section: Discussionmentioning

confidence: 92%

Pneumonia

Abbasi

Abid

2018

TPMJ

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Stroke is a major cause of death and disability globally, with an expected rise in number of patients with ageing and economic transition of developing countries. Pneumonia is one of the major complications after stroke. Stroke associated pneumonia increases risk of death by three fold and is the major cause of morbidity and mortality after the stroke. Objective: To determine the frequency and factors leading to stroke associated pneumonia in all acute stroke patients admitted at a tertiary care hospital. Study Design: Case series. Setting: Medical Department, Aga Khan University Hospital (AKUH), Karachi. Period: six months and extended from 1st July 2015 to 31st December 2015. Material and methods: All adult patients (age 14 years and above) admitted through emergency room in the medical ward of Aga khan university hospital Karachi with the diagnosis of acute stroke on the basis of MRI findings were enrolled after taking informed consent through Non purposive consecutive sampling technique. Demographic data like age and sex were recorded. Diagnosis of stroke associated pneumonia was made on basis of CDC criteria for pneumonia. All analyses was conducted by using the Statistical package for social science SPSS (Release 19.0, standard version, copyright © SPSS; 1989-02). Results: A total of 157 patients admitted with a mean age of the inducted patients were 61.75 ± 13.91 years. According to this stratification, 23 patients (14.65%) were aged less than 45 years and remaining 134 subjects (85.35%) were above the age of 45 years among them 110 were males (70.1 %) and 47 were females (29.9 %). Stroke associated pneumonia was found in 33 (21%) out of 157 patients. Out of 33 patients having stroke associated pneumonia; 14 (42.4%) patients had Diabetes mellitus. Out of 33 patients having stroke associated pneumonia; 28 (84.8%) patients had hypertension. Out of 33 patients having stroke associated pneumonia; 2 (6%) had COPD. Out of 33 patients having stroke associated pneumonia; 2(6%) had Chronic Atrial Fibrillation. Out of 33 patients having stroke associated pneumonia; 21 (63.6%) patients had impaired swallowing. Conclusion: Stroke associated pneumonia is the common and serious complication after stroke. All the efforts should be taken to control various factors leading to stroke associated pneumonia like DM, hypertension, and impaired swallowing to improve stroke outcome.

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“…However, these levels reflect only the fluctuations in extreme conditions. [17][18][19] In addition to the systolic and diastolic blood pressure levels, we also included arterial blood pressure in our study which provides more important data about the daily mean blood pressure levels instead of instant levels. Besides, other studies investigating preeclampsia examined the mean arterial pressure relatively less.…”

Section: Discussionmentioning

confidence: 99%

The evaluation of the serum brain natriuretic peptide concentrations in preeclamptic and healthy pregnant women and its potential relationship with mean arterial blood pressure

Yücedağ¹,

Yılmaz²,

Kırteke³

et al. 2020

Perinatal J

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Serum beyin natriüretik peptid konsantrasyonlar›n›n preeklamptik ve sa¤l›kl› gebe kad›nlarda de¤erlendirilmesi ve ortalama arteryel kan bas›nc› ile aras›ndaki iliflki Amaç: Bu çal›flmada preeklamptik ve normotansif gebe kad›nlar aras›nda serum beyin natriüretik peptid (BNP) konsantrasyonlar›-n› k›yaslayarak bu olgulardaki kan bas›nc› de¤erleri ile aras›ndaki iliflkinin incelenmesi ve preeklampsi patogenezindeki olas› yerinin de¤erlendirilmesi amaçland›. Yöntem: 48 preeklamptik ve 39 normotensif gebe kad›n prospektif olarak çal›flmaya dahil edildi. Gebelerin sistolik diastolik ve ortalama arteryel kan bas›nçlar› saptand›. Serum BNP konsantras-yonlar› enzim immunoassay yöntemi ile ölçüldü. Gruplar aras›ndaki de¤iflkenlerin farkl›l›klar› ba¤›ms›z örnekler t testi ile incelendi. De¤iflkenler aras›ndaki olas› birliktelikler ise Pearson'un korelasyon analizi ile de¤erlendirildi. Bulgular: Gruplar aras›nda yafl (26.18±11.49 y›la karfl›l›k 26.04±14.06 y›l), gestasyonel yafl (31.59±6.94 haftaya karfl›l›k 30.17±5.72 hafta), parite (2.62±1.4'e karfl›l›k 2.53±1.82) ve vücut kitle indeksi (30.71±16.33 kg/m 2 'ye karfl›l›k 30.09±13.82 kg/m 2) yönünden farkl›l›k bulunmuyordu (p>0.05). Sistolik (148.66±61.82 mmHg'ya karfl›l›k 126.44±97.47 mmHg; p=0.015), diastolik (81.19±52.25 mmHg'ya karfl›l›k 97.29± 14.27 mmHg; p=0.019) ve ortalama arteryel bas›nç (113.97±41.76 mmHg'ya karfl›l›k 96.26±27.25 mmHg; p<0.001) preeklampsi ile komplike gebe kad›nlarda daha yüksekti. ‹lave olarak serum BNP kon-santrasyonlar› da preeklamptik gebe kad›nlarda kontrol grubuna k›yasla daha yüksek saptand› (139.42±62.19 pg/mL'ye karfl›l›k 99.28± 19.32 pg/mL; p=0.028). BNP düzeyleri sadece ortalama arteryel ba-s›nç ile anlaml› düzeyde birliktelik gösteriyordu (β=0.241, p=0.037). Ayr›ca BNP düzeyleri ile ortalama arteryel bas›nç aras›nda anlaml› pozitif korelasyon bulundu (r=0.406, p=0.002). Sonuç: Daha genifl prospektif çal›flmalarda preeklampside art›fl gösteren BNP düzeylerinin kan bas›nc› de¤erleri ile birliktelik gösterip göstermedi¤inin de¤erlendirilmesi önerilir. Anahtar sözcükler: Gebelik, preeklampsi, beyin natriüretik peptid, ortalama arteryel kan bas›nc›.

show abstract

Impact of blood pressure, cholesterol and glucose in the association between adiposity measures and coronary heart disease and stroke among Iranian population

Cited by 15 publications

References 32 publications

Analysis of risk factors for carotid intima-media thickness in patients with type 2 diabetes mellitus in Western China assessed by logistic regression combined with a decision tree model

Analysis of risk factors for carotid intima-media thickness in patients with type 2 diabetes mellitus in Western China assessed by logistic regression combined with a decision tree model

Pneumonia

The evaluation of the serum brain natriuretic peptide concentrations in preeclamptic and healthy pregnant women and its potential relationship with mean arterial blood pressure

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