Impact of blood glucose, diabetes, insulin, and obesity on standardized uptake values in tumors and healthy organs on 18F-FDG PET/CT

Büsing, Karen A.; Schönberg, Stefan O.; Brade, Joachim; Wasser, K.

doi:10.1016/j.nucmedbio.2012.10.014

Cited by 95 publications

(110 citation statements)

References 36 publications

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“…Regarding muscle FDG uptake, SUV were higher in MHO and MAO independent of fasting glucose. Interestingly, although muscle (but not adipose tissue) SUV may mildly increase during hyperglycemia , MHO were normoglycemic similar to MHL. While our findings suggest fasting MHO may have altered VAT and muscle glucose uptake, further examination under steady‐state conditions with dynamic PET are warranted to precisely determine glucose flux.…”

Section: Discussionmentioning

confidence: 91%

Visceral and subcutaneous adipose tissue FDG uptake by PET/CT in metabolically healthy obese subjects

Oliveira

Azevedo

Bredella

et al. 2014

Obesity

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ObjectiveTo measure FDG uptake in visceral (VAT) and subcutaneous (SAT) adipose tissue of metabolically healthy obese (MHO) and metabolically abnormal obese (MAO) compared to metabolically healthy lean (MHL) subjects. Given that MHO have increased metabolic risk, we hypothesized that MHO and MAO display similar VAT FDG uptake.Design and MethodsWe examined 18F-FDG-PET/CT studies of 141 adults (n=60 MHL, n=20 MHO, n=61 MAO) to determine VAT and SAT volumes and FDG uptake. Data on CVD risk factors (BMI, abdominal circumference, blood pressure, serum lipids, and fasting plasma glucose) were collected.ResultsMHO and MAO had similar VAT FDG uptake (P=0.74), both significantly lower than MHL (P<0.01) independent of age and gender. SAT FDG uptake was similar across all groups (P>0.2) independent of age and gender. In all groups, VAT FDG uptake was higher than SAT (P<0.0001). In separate sub-analyses of obese groups, VAT FDG uptake was more broadly negatively associated with whole-body adiposity than SAT FDG uptake, and FDG uptake in abdominal adipose depots was positively associated with liver density (P<0.05).ConclusionsFDG uptake in VAT of MHO is similar to MAO and lower than MHL, suggesting these subjects may present similar VAT dysfunction.

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Section: Discussionmentioning

confidence: 91%

Visceral and subcutaneous adipose tissue FDG uptake by PET/CT in metabolically healthy obese subjects

Oliveira

Azevedo

Bredella

et al. 2014

Obesity

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“…Although SUV based on the total body weight is the most commonly used method nowadays, it might be overestimated in obese individuals [43]. In addition, the glucose level, diabetes mellitus, insulin treatment and obesity may affect FDG biodistribution and SUV measurements and thus limit the clinical application of the present study [44]. Finally, besides the concern of radiation exposure, the cost and benefit of FDG PET/CT should be carefully balanced in the current economy of escalating health costs and utilization disparity.…”

Section: Discussionmentioning

confidence: 94%

Association of Esophageal Inflammation, Obesity and Gastroesophageal Reflux Disease: From FDG PET/CT Perspective

Tseng

Lee

et al. 2014

PLoS ONE

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ObjectiveGastroesophageal reflux disease (GERD) is associated with bothersome symptoms and neoplastic progression into Barrett's esophagus and esophageal adenocarcinoma. We aim to determine the correlation between GERD, esophageal inflammation and obesity with 18F-Fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT).MethodsWe studied 458 subjects who underwent a comprehensive health check-up, which included an upper gastrointestinal endoscopy, FDG PET/CT and complete anthropometric measures. GERD symptoms were evaluated with Reflux Disease Questionnaire. Endoscopically erosive esophagitis was scored using the Los Angeles classification system. Inflammatory activity, represented by standardized uptake values (SUVmax) of FDG at pre-determined locations of esophagus, stomach and duodenum, were compared. Association between erosive esophagitis, FDG activity and anthropometric evaluation, including body mass index (BMI), waist circumference, visceral and subcutaneous adipose tissue volumes were analyzed.ResultsSubjects with erosive esophagitis (n = 178, 38.9%) had significantly higher SUVmax at middle esophagus (2.69±0.74 vs. 2.41±0.57, P<.001) and esophagogastric junction (3.10±0.89 vs. 2.38±0.57, P<.001), marginally higher at upper esophageal sphincter (2.29±0.42 vs. 2.21±0.48, P = .062), but not in stomach or duodenum. The severity of erosive esophagitis correlated with SUVmax and subjects with Barrett's esophagus had the highest SUVmax at middle esophagus and esophagogastric junction. Heartburn positively correlated with higher SUVmax at middle oesophagus (r = .262, P = .003). Using multivariate regression analyses, age (P = .027), total cholesterol level (P = .003), alcohol drinking (P = .03), subcutaneous adipose tissue (P<.001), BMI (P<.001) and waist circumference (P<.001) were independently associated with higher SUVmax at respective esophageal locations.ConclusionsEsophageal inflammation demonstrated by FDG PET/CT correlates with endoscopic findings and symptomatology of GERD. Obesity markers, both visceral and general, are independent determinants of esophageal inflammation.

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“…The impact of elevated blood glucose levels, diabetes, insulin treatment, and obesity on 18 F-FDG uptake in tumors and biodistribution in normal organ tissues was studied by Busing et al (30). Hyperglycemia was associated with decreased cerebral uptake and increased skeletal muscle uptake.…”

Section: Premedication (As Needed)mentioning

confidence: 99%

18F-FDG PET and PET/CT Patient Preparation: A Review of the Literature

Surasi

Bhambhvani

Baldwin

et al. 2014

Journal of Nuclear Medicine Technology

101

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Impact of blood glucose, diabetes, insulin, and obesity on standardized uptake values in tumors and healthy organs on 18F-FDG PET/CT

Cited by 95 publications

References 36 publications

Visceral and subcutaneous adipose tissue FDG uptake by PET/CT in metabolically healthy obese subjects

Visceral and subcutaneous adipose tissue FDG uptake by PET/CT in metabolically healthy obese subjects

Association of Esophageal Inflammation, Obesity and Gastroesophageal Reflux Disease: From FDG PET/CT Perspective

18F-FDG PET and PET/CT Patient Preparation: A Review of the Literature

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