Impact of Bariatric Surgery on the Inflammatory State Based on CPR Value

Abstract

Background: PCR (C-reactive protein), produced in the liver after stimuli of inflammatory mediators, is determined as a marker of inflammatory activity (adipocytokines) and is present within adipocyte cells; besides being an inflammatory product, many studies have shown to be a predictor of complications. Aim: To determine if the inflammatory state of the obese patient decreases after bariatric surgery, based on pre and post-operative PCR. Methods: A prospective, observational study in patients undergoing Roux-en-Y gastric by-pass surgery followed up for three months after surgery, with serum preoperative CRP in 30, 60 and 90 days after surgery. Results: A total of 19 patients, who had a mean CRP value before the surgical procedure of 0.80(±0.54) mg/dl, were followed, and when compared to the CRP with 30 days of surgery, they presented a significant increase to 2.68 mg/dl (p=0.012). When compared with the PCR of 60 days after the surgical procedure, it was also higher with the value of 3.32 mg/dl (p=0.27). However, at three months after surgery, the CRP showed a decrease when compared to the preoperative mark, with value of 0.45 mg/dl (p=0.0042). Conclusion: Roux-en-Y gastric bypass was able to decrease the chronic inflammation status of these patients, based on the value of CRP, with three months of surgery.

Impact of Roux-en-Y Gastric Bypass and Vertical Gastrectomy on weight loss: a retrospective and longitudinal study in the State of Paraná, Brazil

“…Five years after BS, our findings reveal that, regardless of sex, RYGB promotes greater weight loss compared with SG, confirming the greater efficacy Gamba Impact of Roux-en-Y Gastric Bypass and Vertical Gastrectomy on weight loss: a retrospective and longitudinal study in the State of Paraná, Brazil of this technique for long-term weight loss 35 . RYGB induces anti-inflammatory responses and stimulates the release and action of incretins (intestinal hormones), particularly glucagon-like peptide 1 (GLP1) 36,37 . A recent study in mice indicated that RYGB is more efficient than SG in preventing weight gain induced by a high-fat diet after BS, indicating a protective effect against excess lipids in the diet 37 .…”

O impacto do Bypass Gástrico em Y de Roux e da Gastrectomia Vertical na perda de peso: um estudo retrospectivo e longitudinal no Estado do Paraná, Brasil

“…Cinco anos após a CB, nossos achados revelam que, independentemente do sexo, a técnica de BGYR promove maior perda de peso em relação a técnica de GV, confirmando a maior eficácia desta técnica para perda de peso a longo prazo 35 . A BGYR induz respostas antiinflamatórias e estimula a liberação e ação da incretinas (hormônios intestinais), em particular o GLP1 (Glucagon Like Peptide 1) 36,37 . Recente estudo em camundongos indicou que BGYR é mais eficiente que a GV em evitar ganho de peso induzido por dieta rica em gordura pós CB, apontando efeito protetor contra excesso de lipídios na dieta 37 .…”

Relationship to Bariatric Surgery and their Gastrointestinal Hormones: how we Weight Loss?

“…It is believed that these deficiencies may persist due to some factors such as restricted intake, food intolerance, poor eating habits, and decreased absorption capacity. Despite having evidence incosistency, most were reported as high as: a 65% drop in B12; 38% folate; 51% vitamin D; 34% vitamin C; 11% for vitamin A; 18% pair B1; 14% for B2 18% for vitamin C. As a consequence of these high drops, the clinical manifestations include osteoporosis, neuropathy, xerophthalmia, nyctalopia and, Wernicke's encephalopathy [15].…”

“…Furthermore, intolerance to red meat, which is a great source of iron, is found in more than 50% of bariatric patients after more than 4 years of procedure. And finally, when physiological demands for iron exceed its absorption (as example in menstruating women), continued depletion of the body's stores of iron will result in iron deficiency anemia [15].…”