Impact of autophagy inhibition on intervertebral disc cells and extracellular matrix
Rebecca Kritschil,
Vivian Li,
Dong Wang
et al.
Abstract:BackgroundIntervertebral disc degeneration (IDD) is a leading contributor to low back pain (LBP). Autophagy, strongly activated by hypoxia and nutrient starvation, is a vital intracellular quality control process that removes damaged proteins and organelles to recycle them for cellular biosynthesis and energy production. While well‐established as a major driver of many age‐related diseases, autophagy dysregulation or deficiency has yet been confirmed to cause IDD.MethodsIn vitro, rat nucleus pulposus (NP) cell… Show more
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