Mechanisms and therapeutic strategies for senescence-associated secretory phenotype in the intervertebral disc degeneration microenvironment

Liu, Yang; Dou, Yiming; Sun, Xun; Yang, Qiang

doi:10.1016/j.jot.2024.02.003

Cited by 2 publications

(1 citation statement)

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“…Accordingly, mechanistic analyses of the cellular senescence and SASP development observed in the microenvironments of various diseases have been vigorously conducted in recent years [ 2 ]. Recent evidence shows that the onset and progression of age-related diseases, such as intervertebral disc degeneration (IDD) [ 5 , 6 , 7 ], osteoarthritis (OA) [ 8 , 9 , 10 , 11 ], and abdominal aortic aneurysm [ 12 , 13 , 14 ], are correlated with large numbers of senescent cells within the lesion.…”

Section: Introductionmentioning

confidence: 99%

Involvement of Matricellular Proteins in Cellular Senescence: Potential Therapeutic Targets for Age-Related Diseases

Fujita,

Sasada,

Iyoda

et al. 2024

IJMS

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Senescence is a physiological and pathological cellular program triggered by various types of cellular stress. Senescent cells exhibit multiple characteristic changes. Among them, the characteristic flattened and enlarged morphology exhibited in senescent cells is observed regardless of the stimuli causing the senescence. Several studies have provided important insights into pro-adhesive properties of cellular senescence, suggesting that cell adhesion to the extracellular matrix (ECM), which is involved in characteristic morphological changes, may play pivotal roles in cellular senescence. Matricellular proteins, a group of structurally unrelated ECM molecules that are secreted into the extracellular environment, have the unique ability to control cell adhesion to the ECM by binding to cell adhesion receptors, including integrins. Recent reports have certified that matricellular proteins are closely involved in cellular senescence. Through this biological function, matricellular proteins are thought to play important roles in the pathogenesis of age-related diseases, including fibrosis, osteoarthritis, intervertebral disc degeneration, atherosclerosis, and cancer. This review outlines recent studies on the role of matricellular proteins in inducing cellular senescence. We highlight the role of integrin-mediated signaling in inducing cellular senescence and provide new therapeutic options for age-related diseases targeting matricellular proteins and integrins.

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