Impact of arteriosclerosis on the functioning of arteriovenous fistula for hemodialysis

Stolić, Radojica; Trajković, Goran; Perić, Vladan; Jovanović, Aleksandar; Šubarić-Gorgieva, Gordana

doi:10.2298/vsp0701013s

Cited by 8 publications

(3 citation statements)

References 14 publications

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“…It has been shown, e.g., that higher extracellular MPO levels could predict an abnormal coronary angiogram in patients undergoing diagnostic cardiac catheterization, whereas in acute coronary syndrome and heart failure, serum MPO activity was predictive for an adverse clinical outcome. 8 We have previously reported that atherosclerosis can significantly reduce the functionality of the AVF, 13 and the results of our current study suggest that high serum MPO activity may predict the occurrence of AVF thrombosis in HD patients. Although these findings may help planning and creation of vascular access, the relevance of extracellular MPO levels in predicting AVF thrombosis is still to be explained.…”

Section: Discussionsupporting

confidence: 70%

Predictive value of serum myeloperoxidase activity for thrombosis of arteriovenous fistulas

Stolić¹,

Trajković

Kostić³

et al. 2014

Hemodialysis International

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Myeloperoxidase is a proinflammatory protein that appears as a result of increased oxidative stress. It plays an important role in the promotion and progression of atherosclerosis. The aim of this study was to determine the importance of MPO as a predictive parameter for thrombosis of arteriovenous fistula (AVF). The study involved monitoring patients with AVFs for hemodialysis over a period of 2 years. There were 41 patients, 19 (46%) men and 22 (54%) women, with mean age of 65 ± 12.7 years. Routine laboratory analyses were carried out in all respondents, including determination of MPO concentration. Gender, demographic and anthropometrical characteristics, smoking, alcohol consumption, as well as the presence of diabetic nephropathy, as an etiological factor of kidney disease, were recorded. The group of patients who developed initial thrombosis of the AVFs had significantly different values for leukocytes (8.5 ± 3.8 vs. 7.3 ± 2.1, P = 0.024), erythrocytes (2.8 ± 0.27 vs. 3.2 ± 0.65; P = 0.019), hemoglobin (88.5 ± 81 vs. 99.1 ± 6.02; P = 0.041), and myeloperoxidase (19.3 ± 4.67 vs. 11.1 ± 4.43; P = 0.007) when compared with the group without fistula thrombosis. Diabetic nephropathy (P = 0.02) characterized the group of patients with thrombosis of the fistula. Diabetic nephropathy (B = 2.53, P = 0.049) and MPO (B = 0.03, P = 0.029) were statistically significant predictors of fistula thrombosis. In our study, MPO and diabetic nephropathy were predictors of thrombosis of the AVF.

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Section: Discussionsupporting

confidence: 70%

Predictive value of serum myeloperoxidase activity for thrombosis of arteriovenous fistulas

Stolić¹,

Trajković

Kostić³

et al. 2014

Hemodialysis International

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“…The presence of extracranial carotid artery stenosis was found to be negatively associated with ideal baseline cardiovascular health in several studies [20,21]. An assessment of carotid intima-media thickness (CIMT) is a good indicator of coronary atherosclerosis [22,23]. In addition, CIMT is an independent predictor of cardiovascular mortality [22,23].…”

Section: Introduction To Extracranial Carotid Atherosclerosismentioning

confidence: 99%

“…An assessment of carotid intima-media thickness (CIMT) is a good indicator of coronary atherosclerosis [22,23]. In addition, CIMT is an independent predictor of cardiovascular mortality [22,23]. Moreover, reduced frequency of subclinical atherosclerosis is associated with ideal cardiovascular health profile [24].…”

Section: Introduction To Extracranial Carotid Atherosclerosismentioning

confidence: 99%

Atherosclerosis at Extracranial Carotid Vessels and Serum Homocysteine

Tai¹,

Ong²,

Toh³

et al. 2019

Inflammatory Heart Diseases

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In this chapter we will discuss more about the role of homocysteine in atherosclerosis and also association between serum homocysteine with extracranial carotid atherosclerosis. Carotid atherosclerosis comprises an increase in carotid intima-media (CIMT) thickening, plaque formation and carotid stenosis. Atherogenic property of homocysteine was discovered in 1969. Atherosclerosis is initiated by endothelial dysfunction. One of the causes of endothelial abnormality is homocysteine. The development of aggregates of homocysteinylated lipoproteins with microorganisms obstructs the vasa vasorum in vulnerable plaques. In one study, serum homocysteine in the highest quartile was independently associated with extracranial carotid artery stenosis ≥50%. In another study, raised serum homocysteine was also independently associated with severe extracranial carotid stenosis in both genders. In other studies, serum homocysteine was significantly associated with carotid artery stenosis in internal carotid arteries and external carotid arteries as well as the degree of stenosis. The hypertensive patients who had raised serum homocysteine were reported to have higher risk of developing asymptomatic extracranial carotid artery stenosis.

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