Impact of Alcohol Use on Inhibitory Control (and Vice Versa) During Adolescence and Young Adulthood: A Review

López‐Caneda, Eduardo; Holguı́n, Socorro Rodrı́guez; Cadaveira, Fernando; Corral, Montserrat; Doallo, Sonia

doi:10.1093/alcalc/agt168

Cited by 113 publications

(86 citation statements)

References 137 publications

(133 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Inhibitory executive control in adolescent and young adult drinkers is of particular interest in understanding the acquisition and persistence of AUDs into adulthood (López-Caneda et al, 2013). Consistent with previous findings (Stevens et al, 2007), ICA identified three functional brain networks associated with successful response inhibition.…”

Section: Response Inhibition and Escalating Maxdrinkssupporting

confidence: 82%

A Preliminary Prospective Study of an Escalation in ‘Maximum Daily Drinks’, Fronto-Parietal Circuitry and Impulsivity-Related Domains in Young Adult Drinkers

Worhunsky

Dager

Meda

et al. 2015

Neuropsychopharmacol

View full text Add to dashboard Cite

Excessive alcohol use in young adults is associated with greater impulsivity and neurobiological alterations in executive control systems. The maximum number of drinks consumed during drinking occasions ('MaxDrinks') represents a phenotype linked to vulnerability of alcohol use disorders, and an increase, or 'escalation', in MaxDrinks may be indicative of greater risk for problematic drinking. Thirty-six young adult drinkers performed a Go/No-Go task during fMRI, completed impulsivity-related assessments, and provided monthly reports of alcohol use during a 12-month follow-up period. Participants were characterized by MaxDrinks at baseline and after follow-up, identifying 18 escalating drinkers and 18 constant drinkers. Independent component analysis was used to investigate functional brain networks associated with response inhibition, and relationships with principal component analysis derived impulsivity-related domains were examined. Greater baseline MaxDrinks was associated with an average reduction in the engagement of a right-lateralized fronto-parietal functional network, while an escalation in MaxDrinks was associated with a greater difference in fronto-parietal engagement between successful inhibitions and error trials. Escalating drinkers displayed greater impulsivity/compulsivity-related domain scores that were positively associated with frontoparietal network engagement and change in MaxDrinks during follow-up. In young adults, an escalating MaxDrinks trajectory was prospectively associated with altered fronto-parietal control mechanisms and greater impulsivity/compulsivity scores. Continued longitudinal studies of MaxDrinks trajectories, functional network activity, and impulsivity/compulsivity-related features may lend further insight into an intermediate phenotype vulnerable for alcohol use and addictive disorders.

show abstract

Section: Response Inhibition and Escalating Maxdrinkssupporting

confidence: 82%

A Preliminary Prospective Study of an Escalation in ‘Maximum Daily Drinks’, Fronto-Parietal Circuitry and Impulsivity-Related Domains in Young Adult Drinkers

Worhunsky

Dager

Meda

et al. 2015

Neuropsychopharmacol

View full text Add to dashboard Cite

show abstract

“…Research assessing impulsive behavior in humans through prepotent response inhibition tasks shows that performance in these tasks steadily improves (reduction in reaction times and commission errors rates) from childhood to young adulthood (Jaeger, 2013; López-Caneda et al, 2014) and starts to decrease in later adulthood (Votruba & Langenecker, 2013). Inhibitory control seems to start maturing at around age 14 (Fischer et al, 1997; Luna et al, 2004; Munoz et al, 1998).…”

Section: Impulsive Behavior Across the Lifespan: Implications For mentioning

confidence: 99%

“…Although the ability to suppress an automatic response begins to develop early in life, efficiency in the process continues to refine through the end of adolescence (Luna et al, 2004). The maturational changes on the adolescent brain, especially the prefrontal cortex, which is linked to prepotent response inhibition, may explain the maintenance of drug-seeking behaviors (López-Caneda et al, 2014). After a period of stabilization in young-to-middle adulthood, performance in prepotent response inhibition tasks starts decreasing in older adulthood.…”

Section: Impulsive Behavior Across the Lifespan: Implications For mentioning

confidence: 99%

Age and impulsive behavior in drug addiction: A review of past research and future directions

Argyriou

Carron

et al. 2018

Pharmacology Biochemistry and Behavior

View full text Add to dashboard Cite

Impulsive behavior is implicated in the initiation, maintenance, and relapse of drug-seeking behaviors involved in drug addiction. Research shows that changes in impulsive behavior across the lifespan contribute to drug use and addiction. The goal of this review is to examine existing research on the relationship between impulsive behavior and drug use across the lifespan and to recommend directions for future research. Three domains of impulsive behavior are explored in this review: impulsive behavior-related personality traits, delay discounting, and prepotent response inhibition. First, we present previous research on these three domains of impulsive behavior and drug use across developmental stages. Then, we discuss how changes in impulsive behavior across the lifespan are implicated in the progression of drug use and addiction. Finally, we discuss the relatively limited attention given to middle-to-older adults in the current literature, consider the validity of the measures used to assess impulsive behavior in middle-to-older adulthood, and suggest recommendations for future research.

show abstract

“…Inhibition, or impulse control, may be a key cognitive feature involved in regulating substance use [25]. Inhibition is a type of executive functioning that refers to the ability to withhold a pre-potent response in order to select a more appropriate, goal-directed response [26, 27].…”

Section: Neural Features That Predate Adolescent Substance Usementioning

confidence: 99%

Alcohol and Drug Use and the Developing Brain

Squeglia

Gray

2016

Curr Psychiatry Rep

190

115

View full text Add to dashboard Cite

Adolescence is an important neurodevelopmental period marked by rapidly escalating rates of alcohol and drug use. Over the past decade, research has attempted to disentangle pre- and post-substance use effects on brain development by using sophisticated longitudinal designs. This review focuses on recent, prospective studies and addresses the following important questions: (1) what neuropsychological and neural features predate adolescent substance use, making youth more vulnerable to engage in heavy alcohol or drug use, and (2) how does heavy alcohol and drug use affect normal neural development and cognitive functioning? Findings suggest that pre-existing neural features that relate to increased substance use during adolescence include poorer neuropsychological functioning on tests of inhibition and working memory, smaller gray and white matter volume, changes in white matter integrity, and altered brain activation during inhibition, working memory, reward, and resting state. After substance use is initiated, alcohol and marijuana use are associated with poorer cognitive functioning on tests of verbal memory, visuospatial functioning, psychomotor speed, working memory, attention, cognitive control, and overall IQ. Heavy alcohol use during adolescence is related to accelerated decreases in gray matter and attenuated increases in white matter volume, as well as increased brain activation during tasks of inhibition and working memory, relative to controls. Larger longitudinal studies with more diverse samples are needed to better understand the interactive effects of alcohol, marijuana, and other substances, as well as the role of sex, co-occurring psychopathology, genetics, sleep, and age of initiation on substance use.

show abstract

Impact of Alcohol Use on Inhibitory Control (and Vice Versa) During Adolescence and Young Adulthood: A Review

Cited by 113 publications

References 137 publications

A Preliminary Prospective Study of an Escalation in ‘Maximum Daily Drinks’, Fronto-Parietal Circuitry and Impulsivity-Related Domains in Young Adult Drinkers

A Preliminary Prospective Study of an Escalation in ‘Maximum Daily Drinks’, Fronto-Parietal Circuitry and Impulsivity-Related Domains in Young Adult Drinkers

Age and impulsive behavior in drug addiction: A review of past research and future directions

Alcohol and Drug Use and the Developing Brain

Contact Info

Product

Resources

About