Impact of Age-Related Macular Degeneration on Vision-Specific Quality of Life: Follow-up from the 10-Year and 15-Year Visits of The Study of Osteoporotic Fractures

Coleman, Anne L.; Yu, Fei; Ensrud, Kristine E.; Stone, Katie L.; Cauley, Jane A.; Pedula, Kathryn L.; Hochberg, Marc C.; Mangione, Carol M.

doi:10.1016/j.ajo.2010.05.030

Cited by 43 publications

(36 citation statements)

References 38 publications

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“…83–85 Results from studies using different tools are mostly aligned with these findings 86–90. A prospective longitudinal study investigating change in visual function in 671 women with AMD over a 5-year period found worse NEI-VFQ scores in those with late AMD at the beginning and end of the study compared to those progressing from early to late AMD 91. Two large-scale cross-sectional studies investigating 2194 and 1052 people with AMD found no association84 and weak association92 with early AMD, respectively, although a smaller study (n=106) using a different PROM did find impaired visual function in those with mild AMD 88.…”

Section: Resultsmentioning

confidence: 79%

How does age-related macular degeneration affect real-world visual ability and quality of life? A systematic review

et al. 2016

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ObjectivesTo review systematically the evidence of age-related macular degeneration (AMD) affecting real-world visual ability and quality of life (QoL). To explore trends in specific topics within this body of the literature.DesignSystematic review.MethodsA systematic literature search was carried out using MEDLINE, EMBASE, CINAHL, PsycINFO, PsychARTICLES and Health and Psychosocial Instruments for articles published up to January 2015 for studies including people diagnosed with AMD, assessing real-world visual ability or QoL as an outcome. Two researchers screened studies for eligibility. Details of eligible studies including study design, characteristics of study population and outcomes measured were recorded in a data extraction table. All included studies underwent quality appraisal using the Mixed Methods Appraisal Tool 2011 Version (MMAT).ResultsFrom 5284 studies, 123 were eligible for inclusion. A range of approaches were identified, including performance-based methods, quantitative and qualitative patient-reported outcome measures (PROMs). AMD negatively affects tasks including mobility, face recognition, perception of scenes, computer use, meal preparation, shopping, cleaning, watching TV, reading, driving and, in some cases, self-care. There is evidence for higher rates of depression among people with AMD than among community dwelling elderly. A number of adaptation strategies have been associated with AMD of varying duration. Much of the research fails to report the type of AMD studied (59% of included studies) or the duration of disease in participants (74%). Of those that do report type studied, the breakdown is as follows: wet AMD 20%, dry AMD 4% and both types 17%.ConclusionsThere are many publications highlighting the negative effects of AMD in various domains of life. Future research should focus on delivering some of this research knowledge into patient management and clinical trials and differentiating between the types of AMD.

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Section: Resultsmentioning

confidence: 79%

How does age-related macular degeneration affect real-world visual ability and quality of life? A systematic review

et al. 2016

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“…This loss of vision leads to difficulty performing daily tasks, such as reading and driving, which can lead to loss of independence and poor quality of life. 1 Despite intense study of this debilitating disease, the exact pathogenesis of the AMD process remains largely unknown.…”

Section: Introductionmentioning

confidence: 99%

Discordance Between Blue-Light Autofluorescence and Near-Infrared Autofluorescence in Age-Related Macular Degeneration

Heiferman

Fawzi

2016

Retina

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Purpose To identify the origin and significance of discordance between blue-light autofluorescence (BL-AF; 488nm) and near-infrared autofluorescence (NI-AF; 787nm) in patients with age-related macular degeneration (AMD). Methods A total of 86 eyes of 59 patients with a diagnosis of AMD were included in this cross-sectional study conducted between March 9, 2015 and May 1, 2015. A masked observer examined the BL-AF, NI-AF, and spectral-domain optical coherence tomography (OCT) images. Areas with discordance of autofluorescence patterns between NI-AF and BL-AF images were correlated with structural findings at the corresponding location in OCT scans. Results 79 eyes had discordance between BL-AF and NI-AF. The most common OCT finding accounting for these discrepancies was pigment migration accounting for 35 lesions in 21 eyes. The most clinically relevant finding was geographic atrophy missed on BL-AF in seven eyes. Conclusions Our findings indicate that variations in the distribution of lipofuscin, melanin and melanolipofuscin account for the majority of discordance between BL-AF and NI-AF. Given our finding of missed geographic atrophy lesions on BL-AF in 24% of eyes with geographic atrophy (7/29 eyes), clinicians should consider multimodal imaging, including NI-AF and OCT, especially in clinical trials of geographic atrophy.

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“…6 Vision-related quality of life has been shown to decline significantly as early AMD progresses to late AMD over a 15-year follow-up. 7 …”

Section: Classification and Epidemiologymentioning

confidence: 99%

The Royal College of Ophthalmologists Guidelines on AMD: Executive Summary

Chakravarthy

Williams

2013

Eye

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Impact of Age-Related Macular Degeneration on Vision-Specific Quality of Life: Follow-up from the 10-Year and 15-Year Visits of The Study of Osteoporotic Fractures

Abstract: Impact of age-related macular degeneration on vision-specific quality of life: Follow-up from the 10-year and 15-year visits of the study of osteoporotic fractures Permalink https://escholarship.org/uc/item/9wc0r0p2

Cited by 43 publications

References 38 publications

How does age-related macular degeneration affect real-world visual ability and quality of life? A systematic review

How does age-related macular degeneration affect real-world visual ability and quality of life? A systematic review

Discordance Between Blue-Light Autofluorescence and Near-Infrared Autofluorescence in Age-Related Macular Degeneration

The Royal College of Ophthalmologists Guidelines on AMD: Executive Summary

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