The Royal College of Ophthalmologists Guidelines on AMD: Executive Summary

Defining response to anti-VEGF therapies in neovascular AMD

“…7,8 Other guidelines or consensus documents have been published by Mitchell et al 9 and Pauliekhoff et al 10 The change in visual function is assessed by visual acuity (VA) measurement at the baseline and all follow-up visits while the macular morphology is accurately assessed by optical coherence tomography (OCT; spectral domain (SD) or higher specification). OCT is a non-invasive imaging modality of the posterior pole that yields important information on the health of the neurosensory retina, retinal pigment epithelium-Bruch's membrane complex and choroidal vasculature and the modulation of these layers with anti-VEGF therapy.…”

Verzögerung des Behandlungsbeginns um mehr als 2 Wochen

“…Es ergab sich eine signifikante Abwei Diskussion Von den deutschen Fachgesellschaf ten wurde bereits seit 2012 ein zeitna her Behandlungsbeginn mit AntiVEGF IVOMs bei allen Indikationen empfohlen [1]. Auch die britische Fachgesellschaft empfiehlt, die Behandlung innerhalb von14 Tagen zu beginnen: "Ideally new pati ents with AMD should not have to wait more than 1 week from referral to clinic and not more than 1 week from clinic to treatment if needed"[10]. Im Rahmen der OCEANStudie wurde aber gezeigt, dass die mittlere Zeitdauer von erster Visus messung bis zur ersten IVOM im deut…”

Comparison of SD-Optical Coherence Tomography Angiography and Indocyanine Green Angiography in Type 1 and 2 Neovascular Age-related Macular Degeneration

“…10 Current guidelines for the management of nAMD state that conventional intravascular fluorescein and/or ICGA are mandatory for diagnosis as they are the basis for visualization of the entire neovascular lesion. [11][12][13] Follow-up may be effectively monitored by OCT alone.…”

“…18,20 Despite the evident benefits of OCTA, 21,22 it has not found its way into primary nAMD diagnosis, and treatment guidelines and FA/ICGA are still considered the gold standard for a comprehensive evaluation of lesion location and morphology. [11][12][13] Current efforts to fully explore and understand the capabilities of OCTA and to set the basis for future diagnostic and therapeutic criteria in nAMD include comparisons of FA and OCTA, [23][24][25] as well as ICGA and OCTA [26][27][28] with variable conclusions.…”