Impact of Age, Gender, and Body Composition on Bone Quality in an Adult Population From the Middle Areas of China

Ding, Zenghui; Chen, Yanyan; Xu, Yang; Zhou, Xu; Xu, Yubing; Ma, Zuchang; Sun, Yining

doi:10.1016/j.jocd.2016.11.001

Cited by 10 publications

(12 citation statements)

References 33 publications

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“…The skeleton responds to mechanical loading by increasing its mass [ 42 ]. Thus, higher BMD values or QUS indices in subjects with higher BMI was a common finding in previous epidemiological studies [ 26 , 27 , 43 , 44 ]. However, BMI is not the most accurate obesity index [ 45 ].…”

Section: Discussionsupporting

confidence: 60%

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Factors Associated with Bone Health in Malaysian Middle-Aged and Elderly Women Assessed via Quantitative Ultrasound

Chin

Low

Dewiputri

et al. 2017

IJERPH

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Risk factors for osteoporosis may vary according to different populations. We aimed to investigate the relationship between risk factors of osteoporosis and bone health indices determined via calcaneal quantitative ultrasound (QUS) in a group of Malaysian women aged 50 years or above. A cross-sectional study was performed on 344 Malaysian women recruited from a tertiary medical centre in Kuala Lumpur, Malaysia. They answered a self-administered questionnaire on their social-demographic details, medical history, lifestyle, and physical activity status. Their height was measured using a stadiometer, and their body composition estimated using a bioelectrical impedance device. Their bone health status was determined using a water-based calcaneal QUS device that generated three indices, namely speed of sound (SOS), broadband ultrasound attenuation (BUA), and stiffness index (SI). A T-score was computed from SI values using a reference database from a mainland Chinese population. Women with three or more lifetime pregnancies, who were underweight and not drinking coffee had a significantly lower BUA. Stepwise multiple linear regression showed that SOS was predicted by age alone, BUA and SI by years since menopause, body mass index (BMI), and number of lifetime pregnancies, and T-score by years since menopause and percentage of body fat. As a conclusion, suboptimal bone health in middle-aged and elderly Malaysian women as indicated by QUS is associated with old age, being underweight, having a high body fat percentage, and a high number of lifetime pregnancies. Women having several risk factors should be monitored more closely to protect their bones against accelerated bone loss.

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Section: Discussionsupporting

confidence: 60%

“…Since younger women were not recruited, the accelerated bone loss during menopause cannot be depicted due to the lack of a comparison group. The negative relationship between age and bone health indicated by BMD or QUS indices was shown in other epidemiological studies as well [ 25 , 26 , 27 ].…”

Section: Discussionsupporting

confidence: 55%

Factors Associated with Bone Health in Malaysian Middle-Aged and Elderly Women Assessed via Quantitative Ultrasound

Chin

Low

Dewiputri

et al. 2017

IJERPH

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“…In our previous research, we have found that BW and FFM positively correlate with bone quality in young adults [7]. In this research, we have further discover that local muscle mass (RLLMM) have a stronger relationship with region bone quality (right calcaneus) comparing with LLLMM and FFM.…”

Section: Discussionsupporting

confidence: 55%

The gender-specific associations between body composition, countermovement jump performance and bone quality in a young Chinese population

Ding¹,

Xu²,

Chen³

et al. 2020

Preprint

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Background: Prophylactic interventions against osteoporosis require a determination of the factors that influence the bone status during adulthood. This study aimed to investigate the associations between body composition parameters (body height (BH), body weight (BW), fat free mass (FFM), fat mass (FM), lower limb muscle mass (LLMM), lower limb fat mass (LLFM)), countermovement jump (CMJ) performance, and calcaneal bone stiffness (SI) in a population of young adults. Methods: The study population included 560 Chinese adults (369 females), aged 20-40 years. Body composition was obtained by bioelectrical impedance analysis (BIA). The CMJ performance (CMJ height (CMJH), the impulse of CMJ phase (ICMJ) and potential energy in the CMJ phase (ECMJ)) was obtained by 3 maximal CMJ trials on ZTJ-II system. Bone quality was measured by quantitative ultrasound (QUS). Results: The present study found BW, FFM and LLMM had significant correlations with SI both in males (r=0.20-0.24, p<0.05) and females (r=0.12-0.20, p<0.05). However, FM and LLFM had positive correlations with SI only in females (p<0.05). CMJ performances, including CMJH, ICMJ and ECMJ, had significant positive correlations with SI in men (r=0.415, p<0.01; r=0.32, p<0.01; and r=0.39, p<0.01, respectively) and women (r=0.248, p<0.01; r=0.26, p<0.01; r=0.3, p<0.01, respectively). Conclusions: This provides evidence that local muscle mass have greater positive associations with calcaneal bone quality than total FFM, and local muscle mass and power are the determinations of region bone quality in young adults. The bone–muscle relationship is more prominent in males than in females.

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“…Moreover, estrogen deficiency which plays a major role in osteoporosis development for both genders is noted to be more pronounced for women and begin at a younger age [ 74 , 76 , 80 ]. Furthermore, males are believed to have higher BMI than females and new research has also highlighted gender-related variations in molecular signaling between bone and muscle independent of purely mechanical interactions that result in gender differences in the acquisition and age-related loss in bone and muscle tissue [ 70 , 71 , 81 ]. Body weight is a known protective factor of bone loss [ 81 ].…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, males are believed to have higher BMI than females and new research has also highlighted gender-related variations in molecular signaling between bone and muscle independent of purely mechanical interactions that result in gender differences in the acquisition and age-related loss in bone and muscle tissue [ 70 , 71 , 81 ]. Body weight is a known protective factor of bone loss [ 81 ]. As was depicted in our results, QUS index amongst individuals who are classified as overweight or obese is higher than those within the normal BMI category, r = 0.33; 95% CI: 0.17–0.49; p = 0.000 and r = 0.48; 95% CI: 0.31–0.65; p = 0.000, respectively.…”

Section: Discussionmentioning

confidence: 99%

A Cross-Sectional Study of the Association between Autoantibodies and Qualitative Ultrasound Index of Bone in an Elderly Sample without Clinical Autoimmune Disease

Iseme

McEvoy

Kelly

et al. 2018

Journal of Immunology Research

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Bone loss is characteristic of the ageing process and a common complication of many autoimmune diseases. Research has highlighted a potential role of autoantibodies in pathologic bone loss. The confounding effects of immunomodulatory drugs make it difficult to establish the contribution of autoantibodies amongst autoimmune disease sufferers. We attempted to examine the relationship between autoantibodies and bone mass in a population of 2812 elderly participants without clinical autoimmune disease. Serum samples were assayed for a panel of autoantibodies (anti-nuclear, extractable nuclear antigen, anti-neutrophil cytoplasmic, thyroid peroxidase, tissue transglutaminase, anti-cardiolipin, rheumatoid factor, and cyclic citrullinated peptide). Bone mass was measured using quantitative ultrasound (QUS) of the calcaneus. The relationship between each autoantibody and bone mass was determined using linear regression models. Anti-nuclear autoantibodies were the most prevalent, positive in approximately 11%, and borderline in roughly 23% of our sample. They were also the only autoantibody observed to be significantly associated with QUS index in the univariate analysis (n = 1628; r = −0.20; 95% CI: −0.40–0.00; p = 0.046). However, statistical significance was lost after adjustment for various other potential confounders. None of the other autoantibodies was associated with QUS index in either univariate or multivariate analysis. We are limited by the cross-sectional nature of the study and the low prevalence of autoantibodies in our nonclinical sample.

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Impact of Age, Gender, and Body Composition on Bone Quality in an Adult Population From the Middle Areas of China

Cited by 10 publications

References 33 publications

Factors Associated with Bone Health in Malaysian Middle-Aged and Elderly Women Assessed via Quantitative Ultrasound

Factors Associated with Bone Health in Malaysian Middle-Aged and Elderly Women Assessed via Quantitative Ultrasound

The gender-specific associations between body composition, countermovement jump performance and bone quality in a young Chinese population

A Cross-Sectional Study of the Association between Autoantibodies and Qualitative Ultrasound Index of Bone in an Elderly Sample without Clinical Autoimmune Disease

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