Impact of age at menarche on obesity and glycemic control in Japanese patients with type 2 diabetes: Fukuoka Diabetes Registry

Sumi, Akiko; Iwase, Masanori; Nakamura, Udai; Fujii, Hiroki; Ohkuma, Toshiaki; Ide, Hitoshi; Jodai-Kitamura, Tamaki; Komorita, Yuji; Yoshinari, Masahito; Kitazono, Takanari

doi:10.1111/jdi.12839

Cited by 23 publications

(24 citation statements)

References 26 publications

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“…Lee et al reported Women with age at menarche ≤12 years had signi cantly higher levels of triglycerides (β coe cient = 37.83, P = 0.02).Beside that hypertriglyceridemia was signi cantly increased at early menarche with 1.99 (95% CI: 1.16-3.41, P < 0 01) (1). Hozoori et al suggested Body mass index, waist circumference (WC), and Weight were inversely and signi cantly associated with the age of menarche (P<0.01) (49). Also Wronka was showed a signi cant relationship between weight and BMI with the age at menarche (50) Strengths and Limitations of the Study:…”

Section: Resultsmentioning

confidence: 84%

Association Between Age at Menarche and Metabolic Syndrome in Southwest Iran: A Population-Based Case Control Study

Cheraghian

Saki

Rahimi

et al. 2021

Preprint

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Background: Age at menarche (AAM) affects women's health outcomes and could be a risk factor for some diseases such as Metabolic Syndrome (MetS). We assessed the association between age at menarche and metabolic syndrome components (obesity, hypertension, type 2 diabetes and cardiovascular disease) in women aged 35 to 70 years in Hoveyzeh, southwest Iran.Methods: This is a case-control study conducted on 5830 women 35 to 70 years in Hoveyzeh cohort study (HCS), a part of the PERSIAN cohort study, between 2016 to 2018. The case group were women with MetS while the controls were women without MetS. Metabolic syndrome is determined based on standard NCEP-ATP III criteria. Demographic, socioeconomic and reproductive history data were gathered face to face by trained interviews. Also, lab, anthropometrics and blood pressure measurements were assayed for participants. Multiple Logistic Regression was used to estimate the association between age at menarche and metabolic syndrome, with adjustment for potential confounding variables.Results: The overall mean age at menarche was 12.60 ± 1.76 years old. Urban and rural women differed in their age at menarche (at age 12.58±1.71 and 12.63±1.83 years, respectively). Comparison of the four menarche age groups (≤10, 11-12, 13-14, 15-16 years) was statistically different showed between age at menarche and MetS. The odds of having metabolic syndrome for groups with menarche age of 13-14 years and 16-15 years, compared to women with a menstrual age ≤10 years, decreased by 21% and 20%, respectively. Conclusion: The present study showed the effect of age at menarche on odds of having MetS in women 35-70 years.

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Section: Resultsmentioning

confidence: 84%

Association Between Age at Menarche and Metabolic Syndrome in Southwest Iran: A Population-Based Case Control Study

Cheraghian

Saki

Rahimi

et al. 2021

Preprint

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“…In adolescence, body composition varies according to age, sexual maturation and physical growth, with physiological increase of adipose tissue, being higher in females, because this accumulation of body fat is essential for the beginning and maintenance of menstrual cycles and consequently for the reproductive process (2,31) . However, it should be considered that this is an age of many changes and therefore is a critical period for the development of obesity (32,33) .…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…The areas under the curve for BMI, WtHR, BAI and BRI were considered very good or excellent in adolescents in general, but, most of these values were lower compared to those analyzed by sex and period of adolescence. Assessing the accuracy of anthropometric indices to estimate body fat is necessary, especially in this age group and due to changes in body composition that occur during adolescence (2) . We suggest the use of specific cutoff points for the various adiposity indices, according to the adolescent's sex and age, in order to obtain a more accurate and reliable diagnosis of excess body fat.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

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Predictive capacity and cut-off points of adiposity indices for body fat prediction according to adolescent periods

et al. 2021

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Overweight is increasing in the adolescent population, being a public health problem in the world. This study aimed to identify the body adiposity indices with the best capacity to predict excess fat tissue and propose cutoff points for them, according to sex and adolescence period. This is a cross-sectional study. We calculated Body Mass Index (BMI), Conicity Index (CI), Body Adiposity Index (BAI), Body Roundness Index (BRI), Waist-to-Height Ratio (WtHR) and Waist-Hip Ratio (WHR). Predictive capacity and cutoff points of adiposity indices were established by ROC (Receiver Operating Characteristic) curves. We determined areas under the ROC curves and confidence intervals, stratified by sex and adolescence period. The best index to identify excess body fat in 10 to 13 years old female adolescents was the WtHR (AUC=0.92), like the BAI in girls aged from 14 to 16 years old (AUC=0.87) and 17 to 19 years old (AUC=0.80). In male adolescents aged from 10 to 13 years old and 14 to 16 years old, the best index was the WtHR (AUC=0.93 and AUC=0.8, respectively), like the BAI in boys aged from 17 to 19 years old (AUC=0.95). The use of indices with specific cutoff points for each period of adolescence and according to sex is important for the reliable diagnosis of excess body fat. It is advisable to use indices together to obtain a more accurate assessment. Thus, the WtHR and BAI are reproducible and reliable, with high sensitivity and specificity values and can be used together with the BMI.

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“…3 The increasing trend of diabetes prevalence has coincided with the decline of age at menarche in China. 4,5 Accumulating evidence suggested that earlier age at menarche was associated with higher risk of obesity, 6 elevated levels of blood glucose, and insulin resistance. 7 However, studies on the association between age at menarche and the risk of diabetes were limited, and the findings were inconsistent.…”

Section: Introductionmentioning

confidence: 99%

Age at menarche, ideal cardiovascular health metrics, and risk of diabetes in adulthood: Findings from the REACTION study

Zhang

et al. 2020

Journal of Diabetes

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Background: Age at menarche was reported to be associated with the risk of diabetes. However, the impact of ideal cardiovascular health metrics (ICVHMs) on the association between age at menarche and adulthood diabetes risk was unclear.Methods: We included 121 431 women from the nationwide, populationbased cohort of the REACTION study (Risk Evaluation of Cancers in Chinese Diabetic Individuals: a Longitudinal Study). The diagnosis of diabetes was based on the oral glucose tolerance test (OGTT) and glycosylated hemoglobin (HbA1c) measurement. Logistic regression and multiplicative interaction analysis were conducted to investigate the potential interaction effect between age at menarche and ICVHMs on the development of diabetes.Results: The multivariable-adjusted odds ratios of diabetes across categories of age at menarche (<14, 14-17, and > 17 years) were 1.22 (95% confidence interval [CI]: 1.17, 1.28), 1.00 (reference), and 0.89 (95% CI: 0.85, 0.93), respectively. In subgroup analysis, significant interactions were detected between total cholesterol/blood pressure levels and age at menarche regarding the risk of diabetes (P for interaction = .0091 and .0019, respectively). The increased risk associated with age at menarche <14 years was observed in participants with three or fewer ICVHMs, but not in women with four or more ICVHMs (P for interaction = .0001). Conclusions: Age at menarche was inversely associated with the risk of diabetes in adulthood in Chinese women, and it appeared to be modified by the presence of ICVHMs. Further studies are needed to clarify the precise interrelationship and the generalizability of our results. K E Y W O R D Sage at menarche, cardiovascular health metrics, diabetes, lifestyle Highlights• Results from previous studies on the association of age at menarche and the risk of diabetes in adulthood were inconsistent, and the impact of ideal cardiovascular health metrics (ICVHMs) on this association was unclear.• This study showed that early age at menarche was associated with an increased risk of diabetes in middle-aged and elderly Chinese women, but not in women with ≥4 ICVHMs.• There was a significant interaction between the number of ICVHMs and the age at menarche in modifying the risk of diabetes.

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Impact of age at menarche on obesity and glycemic control in Japanese patients with type 2 diabetes: Fukuoka Diabetes Registry

Cited by 23 publications

References 26 publications

Association Between Age at Menarche and Metabolic Syndrome in Southwest Iran: A Population-Based Case Control Study

Association Between Age at Menarche and Metabolic Syndrome in Southwest Iran: A Population-Based Case Control Study

Predictive capacity and cut-off points of adiposity indices for body fat prediction according to adolescent periods

Age at menarche, ideal cardiovascular health metrics, and risk of diabetes in adulthood: Findings from the REACTION study

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