Age at menarche, ideal cardiovascular health metrics, and risk of diabetes in adulthood: Findings from the <scp>REACTION</scp> study

Hu, Chunyan; Zhang, Yi; Zhang, Jie; Huo, Yanan; Wan, Qin; Li, Mian; Qi, Hongyan; Du, Rui; Zhu, Yuanyue; Qin, Yingfen; Hu, Ruying; Shi, Lixin; Su, Qing; Yu, Xuefeng; Yan, Li; Qin, Guijun; Tang, Xulei; Chen, Gang; Xu, Min; Wang, Tiange; Zhao, Zhiyun; Chen, Yuhong; Gao, Zhengnan; Wang, Guixia; Shen, Feixia; Luo, Zuojie; Chen, Li; Li, Qiang; Ye, Zhen; Zhang, Yinfei; Liu, Chao; Wang, Youmin; Wu, Shengli; Yang, Tao; Deng, Hongkui; Chen, Lulu; Zhao, Jiajun; Mu, Yiming; Wang, Weiqing; Xu, Yu; Bi, Yufang; Lu, Jieli; Ning, Guang

doi:10.1111/1753-0407.13128

Cited by 13 publications

(13 citation statements)

References 39 publications

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“…The information from the REACTION study has been introduced in detail previously. 21,22 Briefly, during 2011-2012, 259 657 participants aged ≥40 years from 25 study sites across mainland China were recruited, based on the local residence registration records, with no restriction on sex or ethnicity. Individuals who approved and signed the information consent were invited to take part in a detailed interview and a comprehensive clinic visit.…”

Section: Study Populationmentioning

confidence: 99%

Gestational hyperglycemia and the risk of cardiovascular diseases among elderly Chinese women: Findings from the REACTION study

Zeng

Lin

et al. 2021

Journal of Diabetes

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Background: Gestational hyperglycemia increases the risk of diabetes in later life. However, the risk of future cardiovascular diseases (CVD) related to gestational hyperglycemia remains inconclusive. The purpose of this study was to investigate the impact of gestational hyperglycemia on the subsequent risk of CVD and its modifying factors among elderly Chinese women.Methods: We conducted a case-control study of elderly women from the baseline survey of Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudinal (REACTION) study. Women with gestational hyperglycemia (n = 82), and controls matched by age and study site (n = 410) were included. Information on CVD, including reported coronary heart disease, stroke, or myocardial infarction, was collected through an interviewer-assisted questionnaire.Results: Women with gestational hyperglycemia were more likely to develop diabetes (odds ratio [OR], 2.51; 95% confidence interval [CI], 1.50-4.18) and CVD (OR, 1.98; 95% CI, 1.05-3.74). Even without progressing to type 2 diabetes, gestational hyperglycemia was associated with an increased risk of CVD (OR, 2.88; 95% CI, 1.18-7.00). However, subgroup analysis indicated that compared with those without gestational hyperglycemia or hypertension, women with both gestational hyperglycemia and hypertension had higher risk of CVD (OR, 3.98; 95% CI, 1.65-9.58), whereas the risk estimate did not significantly change in women with gestational hyperglycemia alone (OR, 2.15; 95% CI, 0.71-6.57). Stratified analysis indicated that among those with overweight/obesity, inactive physical activity, or unhealthy dietary habits, gestational hyperglycemia increased the risk of CVD. Conclusions:In elderly Chinese women, gestational hyperglycemia was associated with an increased risk of CVD in later life. This association was independent of the progression to diabetes and might be modified by lifestyle factors and hypertension.

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Section: Study Populationmentioning

confidence: 99%

Gestational hyperglycemia and the risk of cardiovascular diseases among elderly Chinese women: Findings from the REACTION study

Zeng

Lin

et al. 2021

Journal of Diabetes

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“…Subgroup analysis revealed no significant effect modification by BMI, abdominal obesity, dyslipidemia, or hypertension on the relationship of age at menarche and menopause with diabetes after 21 (14,34) 22 (14,34) 21 (14,33) 21 (14,34) 0.812 24 (15,37) 21 (14,34) 20 (13,30) multivariable adjustment (p for interaction >0.05) (Table 3).…”

Section: Resultsmentioning

confidence: 99%

“…This may indicate a minor role for adulthood obesity in the relationship between menarche and diabetes. A prospective study has found a significant interaction between the ideal status of TC and blood pressure levels with age at menarche on diabetes 37 . However, TC was considered instead of comprehensive dyslipidemia, and blood pressure classification was not a criterion for hypertension from the study above.…”

Section: Discussionmentioning

confidence: 99%

“…A prospective study has found a significant interaction between the ideal status of TC and blood pressure levels with age at menarche on diabetes. 37 However, TC was considered instead of comprehensive dyslipidemia, and blood pressure classification was not a criterion for hypertension from the study above. This may account for the difference from the results of the present study.…”

Section: Discussionmentioning

confidence: 99%

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Associations of age at menarche and age at menopause with diabetes among postmenopausal women in Chongqing, China

Yuan

Xiao

et al. 2022

J of Obstet and Gynaecol

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Background: Existing studies on the association of age at menarche and age at natural menopause with diabetes are conflicting. Objective: To explore the associations of age at menarche and age at natural menopause with diabetes, and to estimate whether body mass index, abdominal obesity, hypertension, and dyslipidemia would influence the relationships. Methods: In this cross-sectional study, 5090 postmenopausal women were included from the China Multi-Ethnic Cohort Study (CMEC) baseline in Chongqing province. Questionnaires, physical examinations, and biological samples testing were conducted. Logistic regression was used to generate odds ratios (ORs) and 95% confidence intervals (CIs). And restricted cubic splines were performed to evaluate the pattern of association between ages at menarche and menopause with diabetes. Results: The adjusted ORs for diabetes grouped by age at menarche (<12, 12-17, >17 years) were 0.76 (95%CI: 0.42-1.40), 1.00 (reference), and 0.73 (95%CI: 0.57-0.94). Similarly, the adjusted ORs for diabetes grouped by age at menopause (<44, 44-52, >52 years) were 1.38 (95%CI: 1.04-1.82), 1.00 (reference), and 1.11 (95%CI: 0.89-1.39). No significant interaction of age at menarche and menopause with body mass index, abdominal obesity, hypertension, and dyslipidemia in odds of diabetes was observed. Conclusion: Late menarche is associated with a lower prevalence of diabetes, while early natural menopause is associated with a higher prevalence of diabetes. No significant effect modification was observed by body mass index, abdominal obesity, hypertension, or dyslipidemia.

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“…The study population was derived from the REACTION study, including 259,657 participants from 25 communities across mainland China. The details of the study population were described previously ( 25 , 26 ). Briefly, community dwelling adults aged 40 years or older were invited to participate the baseline survey during 2011-2012.…”

Section: Methodsmentioning

confidence: 99%

Association Between Age at Diagnosis of Type 2 Diabetes and Cardiovascular Diseases: A Nationwide, Population-Based, Cohort Study

Lin

Zhu

et al. 2021

Front. Endocrinol.

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ObjectivesNationwide studies focusing on the impact of early-onset type 2 diabetes and obesity on the development of cardiovascular diseases (CVD) are limited in China. We aimed to investigate the association between age at diagnosis of type 2 diabetes and the risk of CVD, and to further examine the modifying effect of obesity on this association among Chinese adults.MethodsThis study included 23,961 participants with previously diagnosed diabetes from a large nationwide population-based cohort study across mainland China. With an interviewer-assisted questionnaire, we collected detailed information on CVDs. Logistic regression analysis was used to evaluate the risk of CVDs associated with age at diagnosis of diabetes.ResultsCompared with patients with late-onset diabetes (≥60 years), those with earlier-onset diabetes had increased risks for CVD, with adjusted ORs (95% CIs) of 1.72 (1.36-2.17), 1.52 (1.31-1.75) and 1.33 (1.19-1.48) for patients diagnosed aged <40, 40-49 and 50-59 years, respectively. Each 5-year earlier age at diagnosis of type 2 diabetes was significantly associated with 14% increased risk of CVD (OR, 1.14; 95%CI, 1.11-1.18). This association was more prominent for patients with obesity than those with normal body mass index (BMI). Significant interaction was detected between age at diagnosis and BMI categories on CVD risk (P for interaction=0.0457).ConclusionEarly-onset type 2 diabetes was significantly associated with higher risk of CVD, and this association was more prominent among patients with obesity.

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Age at menarche, ideal cardiovascular health metrics, and risk of diabetes in adulthood: Findings from the REACTION study

Cited by 13 publications

References 39 publications

Gestational hyperglycemia and the risk of cardiovascular diseases among elderly Chinese women: Findings from the REACTION study

Gestational hyperglycemia and the risk of cardiovascular diseases among elderly Chinese women: Findings from the REACTION study

Associations of age at menarche and age at menopause with diabetes among postmenopausal women in Chongqing, China

Association Between Age at Diagnosis of Type 2 Diabetes and Cardiovascular Diseases: A Nationwide, Population-Based, Cohort Study

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