Impact of advanced maternal age on adverse infant outcomes: A Japanese population-based study

Koshida, Shigeki; Arima, Hisatomi; Fujii, Takako; Ito, Yoshiya; Murakami, Takashi; Takahashi, Kentaro

doi:10.1016/j.ejogrb.2019.08.011

Cited by 14 publications

(19 citation statements)

References 23 publications

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“…Other study found that supplementation with DHA, folic acid, zinc and other nutrients during pregnancy can reduce the incidence of LBW. (41,42) Previous studies found the effects of maternal age, maternal history, and environmental factors on birth weight, (43,44) but they do not fully explain the causes of low birth weight. In recent years, studies have explained the occurrence of LBW from the perspective of lowgrade inflammation.…”

Section: Discussionmentioning

confidence: 98%

Relationship between dietary inflammatory index, hs-CRP level in the second trimester and neonatal birth weight: a cohort study

Yang

Kan

et al. 2020

J. Clin. Biochem. Nutr.

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The aim of this study was to investigate whether diet plays a role in the effect of inflammation on birth weight. The normal pre pregnancy body mass index and healthy single pregnant women without classical inflammatory were recruited at 16-20 weeks of pregnancy and provided blood sample to measure plasma high sensitive C reactive protein (hs CRP) level. The Dietary Inflammatory Index (DII) score was calculated by a three day 24 h recall method, and a cohort of 307 eligible pregnant women was established. According to birth weight, the subjects were divided into three groups: normal birth weight (NBW) group, low birth weight (LBW) group, and high birth weight (HBW) group. The hs CRP level and DII score were significantly different between NBW and LBW groups. The risk of higher hs CRP in the pro inflammatory dietary group was 1.89 times than the control group (95% CI: 1.05, 3.42). The risk of LBW with higher hs CRP was 3.81 times than normal hs CRP (95% CI: 1.26, 11.56). The risk of LBW in the pro inflammatory dietary group was 10.44 times than in the anti inflammatory dietary group (95%CI: 1.29, 84.61). The pro inflammatory dietary in the second trimester affects the hs CRP level, showing a positive correlation. And both of two factors increase the risk of LBW.

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Section: Discussionmentioning

confidence: 98%

Relationship between dietary inflammatory index, hs-CRP level in the second trimester and neonatal birth weight: a cohort study

Yang

Kan

et al. 2020

J. Clin. Biochem. Nutr.

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“…Kozuki et al (33) and Kenny et al (35) reported that there was no evidence to support an association between advanced maternal age and SGA. However, there are also studies reporting that the risk of SGA increases exponentially with maternal age (36,37).…”

Section: Discussionmentioning

confidence: 99%

Endometrial thickness is associated with incidence of small-for-gestational-age infants in fresh in vitro fertilization–intracytoplasmic sperm injection and embryo transfer cycles

Guo

Zhang

et al. 2020

Fertility and Sterility

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Objective: To investigate whether endometrial thickness (EMT) is associated with adverse obstetric and neonatal outcomes in fresh in vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET) cycles. Design: Retrospective cohort study. Setting: University-based reproductive medical center. Patient(s): Women under the age of 42 years who underwent IVF/ICSI treatment and received fresh ET in our unit from January 2017 to December 2018, resulting in a live singleton birth. Intervention(s): Controlled ovarian hyperstimulation and IVF/ICSI; fresh ET. Main Outcome Measure(s): Birth weight, gestational age, small for gestational age (SGA), large for gestational age (LGA), placenta previa, placental abruption, hypertensive disorders, and gestational diabetes mellitus. Result(s): The risk of being born SGA was statistically significantly increased in the EMT %7.5 mm group compared with those from the EMT >12 mm group (adjusted odds ratio [aOR] 2.391; 95% confidence interval [CI], 1.155-4.950). Moreover, maternal body mass index, secondary infertility, preterm delivery, and hypertensive disorders were all independent predictors for SGA. The mean birth weights of singletons in women with EMT %7.5 mm were lower than in the groups with EMT >7.5-12 mm and EMT >12 mm (3.25 AE 0.56 kg vs. 3.38 AE 0.51 kg and 3.39 AE 0.53 kg, respectively). Conclusion(s):After fresh IVF/ICSI-ET, the risk of SGA was increased twofold in women with EMT %7.5 mm compared with women with EMT >12 mm. We suggest that women with a thin EMT after obtaining a pregnancy by IVF should receive improved prenatal care to reduce the risk of delivering a SGA infant. (Fertil Steril Ò 2020;113:745-52. Ó2019 by American Society for Reproductive Medicine.) El resumen está disponible en Español al final del artículo.

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“…Although some studies have observed that most women >45 years of age have good pregnancy outcomes and can cope with the physical and emotional stress of pregnancy and parenting [4][5][6][7][8], there have been numerous studies regarding various adverse maternal outcomes associated with AMA, including fetal chromosomal abnormalities, cesarean delivery, preeclampsia, postpartum hemorrhage, gestational diabetes mellitus (GDM)/diabetes mellitus (DM), thrombosis, hysterectomy, and, in adjusted analyses, amniotic fluid embolism and increased risk of obstetric shock [9][10][11][12]. In addition, unfavorable infant outcomes, such as preterm birth, low birth weight (LBW), small for gestational age, and perinatal mortality, could be more likely in an AMA group [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Impact of Maternal Age on Singleton Pregnancy Outcomes in Primiparous Women in South Korea

Kim

Lee

et al. 2022

JCM

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We aimed to determine the association between maternal age and pregnancy outcomes in singleton primigravidae in South Korea. We reviewed the medical data of singleton primigravidae women who gave birth between 2013 and 2018 and underwent the National Health Screening Examination using the administrative database from the National Health Insurance claims data. As advanced maternal age is associated with various comorbidities that could affect pregnancy outcomes, we divided the patients according to their age and comparatively analyzed the prevalence of high-risk pregnancy complications including rates of cesarean delivery, after adjusting for maternal demographics. Perinatal and postpartum complications according to maternal age were also investigated. Overall, 548,080 women were included in this study: 441,902 were aged <35 years; 85,663, 35–39 years; 20,515, ≥40 years. Patients’ demographics differed according to their age. Increasing maternal age was significantly associated with higher income levels and higher rates of obesity, pre-existing diabetes, and hypertension. With the increasing maternal age, the rate of obstetric complications, including gestational diabetes, preeclampsia, placenta previa, placental abruption, and cesarean delivery, increased. Maternal age was also positively correlated with perinatal morbidity including preterm birth and low birth weight. Additionally, advanced maternal age was a risk factor for hospitalization before delivery, more frequent outpatient visits, and readmission after delivery. These observations were maintained in the multivariate analysis results. Advanced maternal age appears to be associated with various adverse obstetric outcomes for primigravidae women, and the frequency of hospitalizations was higher in this group. Considering the current social environment of late pregnancies and childbirth in South Korea, effective policy consideration is required to support safe childbirth in women with advanced maternal age.

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Impact of advanced maternal age on adverse infant outcomes: A Japanese population-based study

Cited by 14 publications

References 23 publications

Relationship between dietary inflammatory index, hs-CRP level in the second trimester and neonatal birth weight: a cohort study

Relationship between dietary inflammatory index, hs-CRP level in the second trimester and neonatal birth weight: a cohort study

Endometrial thickness is associated with incidence of small-for-gestational-age infants in fresh in vitro fertilization–intracytoplasmic sperm injection and embryo transfer cycles

Impact of Maternal Age on Singleton Pregnancy Outcomes in Primiparous Women in South Korea

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