Endometrial thickness is associated with incidence of small-for-gestational-age infants in fresh in vitro fertilization–intracytoplasmic sperm injection and embryo transfer cycles

Guo, Zizhen; Xu, Xinxin; Zhang, Lin; Zhang, Liping; Yan, Lei; Ma, Jinlong

doi:10.1016/j.fertnstert.2019.12.014

Cited by 56 publications

(70 citation statements)

References 41 publications

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“…Guo et al studied EMT on the day of hCG detection in fresh-embryo transfer cycles. They found insu cient EMT to be a risk factor for neonatal SGA [11]. Thus, in accordance with our results, newborns with a thinner endometrium had a lower weight and an increased risk of SGA.…”

Section: Discussionsupporting

confidence: 92%

A thinner endometrium is associated with lower newborn birth weight during in vitro fertilization–frozen-embryo transfer: cohort study

Zhang

Luo

Han

et al. 2021

Preprint

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BackgroundThe purpose of this study is to explore the influence of endometrial thickness (EMT) before embryo transfer on birth weight after in vitro fertilization–frozen-embryo transfer (IVF–FET).MethodsThis was a retrospective cohort study. We collected the medical records associated with singleton live births from Tianjin Central Obstetrics and Gynecology Hospital from June 2015 to February 2019 after IVF–frozen-embryo transfer (FET). Patients were ≤ 42 years at delivery. Outcomes related to newborns were birth weight, gestational age, delivery mode, low birth weight, and prevalence of macrosomia. Outcomes related to pregnant women were gestational hypertension, gestational diabetes mellitus, premature rupture of membranes and placenta previa.ResultsThe birth weight of singleton newborns was higher for newborns delivered by patients with EMT > 12 mm before embryo transfer than newborns delivered by patients with a thinner endometrium. Regression analysis showed that the EMT ≥ 12 mm group had a gain in mean birth weight of 85.107 g compared with that in the EMT < 8 mm group, whereas the group with EMT of 8–12 mm had an increase in mean birth weight of 25.942 g compared with that in the EMT < 8 mm group. Hypertension during pregnancy, premature rupture of membranes, placenta previa, newborn sex, gestational age, delivery mode, number of implanted embryos, follicle-stimulating hormone (FSH) level, estradiol (E2) level, and pre-pregnancy body mass index (BMI) were all independent predictors of newborn birth weight. The regression model for predicting the newborn birth weight was: Y (birth weight) = 25.942×(EMT of 8–12 mm) + 85.107×(EMT > 12 mm) + 123.483×(hypertension during pregnancy) + 148.859×(premature rupture of membranes) + 182.342×(placental position) − 126.242×(newborn sex) + 23.837×(number of days of pregnancy) + 130.487×(delivery mode) − 55.023×(number of implanted embryos) − 6.215×FSH level − 1.124×E2 level + 22.218×BMI − 4468.101.Conclusion(s)EMT before embryo transfer in patients undergoing their first freeze–thaw embryo transfer cycle is related to the weight of newborn singletons. The newborn birth weight for patients with a thinner endometrium is lower. EMT should be increased before embryo transfer to improve neonatal outcomes after fertility treatment.

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Section: Discussionsupporting

confidence: 92%

A thinner endometrium is associated with lower newborn birth weight during in vitro fertilization–frozen-embryo transfer: cohort study

Zhang

Luo

Han

et al. 2021

Preprint

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“…All patients were given a conventional ovarian stimulation regimen, and TVU was used to monitor the growth and development of follicles. Different ovarian stimulation protocols were selected according to the patient's age and ovarian function, including gonadotrophin-releasing hormone (GnRH) agonist long protocols, GnRH agonist short protocols, flexible GnRH antagonist protocols, mild stimulation protocols, and natural cycle protocols, which have been previously reported (10). Next, hCG was given intramuscularly at a dose of 4,000-10,000 IU when two or more follicles measured ≥18 mm.…”

Section: Ivfmentioning

confidence: 99%

Fresh versus frozen embryo transfer in women with thin endometrium: a retrospective cohort study

Guo¹,

Chu²,

Zhang³

et al. 2020

Ann Transl Med

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Background: A thin endometrium affects embryo implantation. We designed a retrospective cohort study to analyze the differences of in vitro fertilization-intracytoplasmic sperm injection (IVF-ICSI) outcomes between fresh embryo transfer (ET) and frozen ET in patients with a thin endometrium.Methods: The present study comprised of 1,110 patients with a thin endometrium undergoing IVF-ICSI between January 2013 and December 2017 in our unit. Propensity score matching (PSM) was used to balance the influence of intergroup confounding factors and to compare the pregnancy outcomes of the matched patients in the two groups. The fresh embryo group and frozen embryo group consisted of 632 and 478 women, respectively. After PSM, 173 patients were included in the two groups, respectively. Results:The frozen embryo group showed a higher live birth rate (31% vs. 18.4%, P<0.001; 30.6% vs. 19.7%, P=0.019), clinical pregnancy rate (40% vs. 26.4%, P<0.001; 38.7% vs. 25.4%, P=0.008), and biochemical pregnancy rate (46.2% vs. 32.9%, P<0.001; 44.5% vs. 31.8%, P=0.020) than the fresh embryo group before and after PSM.Conclusions: Our results demonstrated that for women with a thin endometrium who were undergoing IVF, the live birth rate, clinical pregnancy rate, and biochemical pregnancy rate after frozen ET were significantly higher than in the fresh ET group.

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“…In an analysis of over 6,000 singleton newborns, Zhang et al (26) found that among women undergoing day 3 frozen embryo transfer, an endometrial thickness of <8 mm was significantly associated with lower birth weight compared with an endometrial thickness of R10 mm after adjusting for gestational age. In addition, Guo et al (27) found that endometrial thickness was significantly associated with birth weight and those with an endometrial thickness of %7.5 mm were significantly more likely to have a small-for-gestational-age neonate compared with to those with an endometrial thickness of >12 mm. Taken together, these studies indicate that endometrial thickness is a significant factor in healthy pregnancy and fetal development and support using a goal endometrial thickness of R7 mm as a conservative cutoff for progressing with embryo transfer.…”

Section: Discussionmentioning

confidence: 99%

The effect of endometrial thickness on live birth outcomes in women undergoing hormone-replaced frozen embryo transfer

2021

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Objective: To determine the impact of endometrial thickness on live birth outcomes and obstetric complication rate after hormonereplaced frozen embryo transfer. Design: Retrospective cohort study. Setting: Large, urban, academic fertility center. Patient(s): All patients with a singleton live birth after single euploid embryo transfer (by array comparative genomic hybridization or next-generation sequencing) in a hormone-replaced frozen embryo transfer cycle between January 2017 and December 2018 were reviewed. Intervention(s): None. Main Outcome measure(s): The primary outcomes were birth weight and obstetric complication rate. Result(s): A total of 492 patients were included. The median endometrial thickness was 8.60 mm (range, 6.0-20.0). The median gestational age at live birth was 39.4 weeks with a median birth weight of 3,345.2 g. Endometrial thickness was significantly correlated with birth weight. When patients were dichotomized into groups (those with an endometrial thickness of <7 mm and those with an endometrial thickness of >7 mm), neonates born from endometria with a thickness of <7 mm were born earlier (37.3 vs. 39.4 weeks and born with lower birth weights (2,749.9 vs. 3,345.2 g). It should be noted that only seven patients had an endometrium measuring <7 mm. Moreover, 7.1% (n ¼ 35) of patients had an obstetric complication. Endometrial thickness was not significantly associated with obstetric complications, even with adjustments for age and medical history. Conclusion(s): Endometrial thickness may be a valuable predictor of placental health and birth weight. Further study is required to examine the relationship with individual obstetric complications, as our study may not have been powered to observe differences in obstetric complication rate, as well as the relationship between endometrial thickness and outcomes in natural frozen embryo transfer cycles.

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Endometrial thickness is associated with incidence of small-for-gestational-age infants in fresh in vitro fertilization–intracytoplasmic sperm injection and embryo transfer cycles

Cited by 56 publications

References 41 publications

A thinner endometrium is associated with lower newborn birth weight during in vitro fertilization–frozen-embryo transfer: cohort study

A thinner endometrium is associated with lower newborn birth weight during in vitro fertilization–frozen-embryo transfer: cohort study

Fresh versus frozen embryo transfer in women with thin endometrium: a retrospective cohort study

The effect of endometrial thickness on live birth outcomes in women undergoing hormone-replaced frozen embryo transfer

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