Impact of Advanced Maternal Age on Pregnancy Outcome

Abstract

The aim of this study was to compare the pregnancy outcome and delivery complications in women 40 years or older (cases) to that of women 20 to 30 years old (controls). Over a 5-year period, 319 cases had a singleton delivery in our institution. These women were compared with 326 controls. Parity was significantly higher in cases compared with controls (3.2 vs. 1.8). Advanced maternal age, compared with younger age, was associated with significantly higher rates of preterm delivery (16.0 vs. 8.0%), cesarean delivery (CS) (31.3 vs. 13.5%), and the occurrence of one or more antepartum complications (29.5 vs. 16.6%). When the two groups were subdivided according to parity, rates of preterm delivery, CS, preeclampsia, gestational diabetes, chronic hypertension, and labor induction were each significantly higher among older multiparas compared with control multiparas. However, only preterm delivery, CS rates, and uterine fibroids were found to be significantly higher in older nulliparous compared with young nulliparous women. We conclude that multiparous women at least 40 years old have a higher antepartum complication rate including intrauterine fetal death compared with younger women.

Re: Moore EK, Irvine LM. 2014. The impact of maternal age over forty years on the caesarean section rate: six year experience at a busy district general hospital. Journal of Obstetrics and Gynaecology 34:238–240

“…Th e eff ect of advanced maternal age on pregnancy and neonatal outcome is still controversial (Seoud et al 2002). We strongly agree with the authors affi rming ' the clinicians have a lower threshold for interventions in this group of women ' .…”

Resultados perinatais em gestações tardias

“…International studies show that prematurity has been more frequently observed among women older than 35 years of age (11,19) . A study conducted in Lebanon reported that the difference in the rate of preterm deliveries remained significantly higher among older women, even when women who had a medical or obstetrical indication to induce labor were excluded, indicating the inherent risk of preterm delivery among older women (21) .…”

Magzati és anyai betegségek kockázata 40 évesnél idősebb édesanyák esetén

“…Ma már számos közlemény [8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50] : 1,32). A császármetszés gyakorisága először szülőknél és többedszer szülőknél egyaránt lényegesen magasabb a 30 éves korosztályhoz képest.…”