Impact of active sites on encapsulation of curcumin in Metal Organic Frameworks

Abstract

In this study, we present the investigation of the curcumin loading and release properties of four different Metal-Organic Frameworks (MOFs) with varying metal centres and organic ligands. Through our research, we have identified HKUST-1 and MIL-100, highly porous copper and iron-containing MOFs, that exhibit specific interactions with curcumin, leading to high encapsulation efficiencies (55%-75%) even at low concentrations as 6ppm. The binding modes of curcumin onto MOFs have been investigated using a combined experimental and computational approach. Furthermore, our drug-releasing studies have revealed slow and prolonged release for over two days, which further indicates the specific interactions of curcumin with HKUST-1 and MIL-100. To the best of our knowledge, this is the first comparative study that investigates the drug delivery properties of curcumin using Copper, Ferrous, and Zinc MOFs. Our findings pave the way for the development of stable, highly interactive MOFs as drug carriers for curcumin, which has the potential to overcome its poor aqueous solubility and rapid metabolism, and enhance its pharmacological activities in medicine.

Potent activity of Metal-Organic Framework nanoparticles loaded by hydrophobic natural products via one-pot synthetic method against pancreatic cancers

“…Both UiO66/Curc and PSM nanoparticle formulations showed displayed around 0.5 mg/mL potency (Table 1 and Fig. S23, 24,26).…”

“…Drug delivery by nanoparticulate vectors such as nanosized Metal organic frameworks (MOFs), comprising metal ions/clusters with organic ligand linkages, have become a prospective platform to overcome chemotherapy limitations owing to their high porosity, surface area, biocompatibility, and biodegradability [20,21]. Various types of MOF based drug delivery system such as Mg-, Ni-, Zn-, or Co-MOF-74 microparticles [22], MOF-100 [23], HKUST-1 [24], ZIF-8 [25], Fe-MIL-88B-NH2 [26] and UiO66 [16]have been employed to be loaded by curcumin. However, the methods included impregnating https://doi.org/10.26434/chemrxiv-2023-mhb04 ORCID: https://orcid.org/0000-0003-2570-6133 Content not peer-reviewed by ChemRxiv.…”

Recent Trends in Curcumin-Containing Inorganic-Based Nanoparticles Intended for In Vivo Cancer Therapy

“… Scheme of metal–organic frameworks (MOFs)’ interactions of metals to curcumin hydroxyl groups. Based on Munasinghe et al, 2023 [ 88 ]. …”

“…This nanomaterial has been widely developed as a carrier for the effective delivery of drugs to tumor tissues [87]. These systems have been associated with curcumin through interactions between the phenol and enol sites of this molecule, showing strong evidence of chelation-type bonds with the MOFs (Figure 5) [88]. Hence, Dehghani and colleagues developed nanoparticles with multifunctional theragnostic capacity.…”