Improved Cytotoxicity and Induced Apoptosis in HeLa Cells by Co‐loading Vitamin E Succinate and Curcumin in Nano‐MIL‐88B‐NH₂

Abstract

One of the strategies for improved therapeutic effects in cancer therapy is combination chemotherapy. In this study, a flexible nano‐MOF (Fe‐MIL‐88B‐NH2) has been synthesized with the sonochemical process, co‐loaded with alpha‐tocopheryl succinate (TOS) and Curcumin (CCM). The anticancer activity of co‐loaded Fe‐MIL‐88B‐NH2 (Fe‐MIL‐88B‐NH2/TOS@CCM) against the HeLa cells has been compared with the single‐loaded counterpart (Fe‐MIL‐88B‐NH2@CCM). MTT analysis indicates improved cytotoxicity of Fe‐MIL‐88B‐NH2/TOS@CCM. More investigations have been done with cell apoptosis assay, and the data indicates more apoptosis in the case of co‐loaded nano‐MOF. This study indicates the positive effect of the TOS presence on the anticancer effect enhancement of Fe‐MIL‐88B‐NH2@CCM to prepare a more efficient drug delivery nano‐system.