Impact of acid type and glutaraldehyde crosslinking in the physicochemical and mechanical properties and biodegradability of chitosan films

Pavoni, Julia Menegotto Frick; Santos, Nicole Z. dos; May, Izabelly Cassia; Pollo, Liliane Damaris; Tessaro, Isabel Cristina

doi:10.1007/s00289-020-03140-4

Cited by 57 publications

(38 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The chitosan and Chi-TEOS films were translucent in appearance with a slight yellow color. The Chi-GA film also displayed a translucent appearance but with a more vibrant yellow color, as was reported previously [ 33 , 34 ]. Each film was thin and flexible to varying degrees, with little or no bubbles being observable by the naked eye.…”

Section: Resultssupporting

confidence: 81%

A Slot-Die Technique for the Preparation of Continuous, High-Area, Chitosan-Based Thin Films

et al. 2021

View full text Add to dashboard Cite

Chitosan-based films have a diverse range of potential applications but are currently limited in terms of commercial use due to a lack of methods specifically designed to produce thin films in high volumes. To address this limitation directly, hydrogels prepared from chitosan, chitosan-tetraethoxy silane, also known as tetraethyl orthosilicate (TEOS) and chitosan-glutaraldehyde have been used to prepare continuous thin films using a slot-die technique which is described in detail. By way of preliminary analysis of the resulting films for comparison purposes with films made by other methods, the mechanical strength of the films produced was assessed. It was found that as expected, the hybrid films made with TEOS and glutaraldehyde both show a higher yield strength than the films made with chitosan alone. In all cases, the mechanical properties of the films were found to compare very favorably with similar measurements reported in the literature. In order to assess the possible influence of the direction in which the hydrogel passes through the slot-die on the mechanical properties of the films, testing was performed on plain chitosan samples cut in a direction parallel to the direction of travel and perpendicular to this direction. It was found that there was no evidence of any mechanical anisotropy induced by the slot die process. The examples presented here serve to illustrate how the slot-die approach may be used to create high-volume, high-area chitosan-based films cheaply and rapidly. It is suggested that an approach of the type described here may facilitate the use of chitosan-based films for a wide range of important applications.

show abstract

Section: Resultssupporting

confidence: 81%

A Slot-Die Technique for the Preparation of Continuous, High-Area, Chitosan-Based Thin Films

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Wegrzynowska-Drzymalska et al [ 50 ] indicated that the elongation at break of chitosan-based materials decreases when a higher amount of crosslinking agent (glutaraldehyde) is used. Pavoni et al [ 53 ] also investigated the effect that addition of glutaraldehyde (0.5, 1, 2, 5, and 10 wt.% glutaraldehyde content) had on the mechanical properties of chitosan. They observed that the application of the crosslinking agent promoted a decrease in the elongation at break, from 45±3% (pure chitosan) to 3±1% in the case of chitosan crosslinked with 10 wt.% of glutaraldehyde.…”

Section: Resultsmentioning

confidence: 99%

Examining the Impact of Squaric Acid as a Crosslinking Agent on the Properties of Chitosan-Based Films

Olewnik-Kruszkowska

Gierszewska

Grabska-Zielińska

et al. 2021

IJMS

View full text Add to dashboard Cite

Hydrogels based on chitosan are very versatile materials which can be used for tissue engineering as well as in controlled drug delivery systems. One of the methods for obtaining a chitosan-based hydrogel is crosslinking by applying different components. The objective of the present study was to obtain a series of new crosslinked chitosan-based films by means of solvent casting method. Squaric acid—3,4-dihydroxy-3-cyclobutene-1,2-dione—was used as a safe crosslinking agent. The effect of the squaric acid on the structural, mechanical, thermal, and swelling properties of the formed films was determined. It was established that the addition of the squaric acid significantly improved Young’s modulus, tensile strength, and thermal stability of the obtained materials. Moreover, it should be stressed that the samples consisting of chitosan and squaric acid were characterized by a higher swelling than pure chitosan. The detailed characterization proved that squaric acid could be used as a new effective crosslinking agent.

show abstract

“…The analysis of crystallinity aspects of the acyclovir, pure CS, CLCS, ACV-CLCS physical mix, and ACV loaded-CLCS granules were accomplished with an X-ray diffractometer (Phillips Xpert) that operates at 40 kV, 30 mA using a Copper line focus Xray tube (Copper anode as X-ray source) with Nickel kβ absorber producing Kα1 radiation (λ = 1.5406˚A) [19]. Diffraction patterns were recorded over the 2θ range of 10-80•.…”

Section: X-ray Diffraction Measurements (Xrd)mentioning

confidence: 99%

Chemical Modification and Characterization of Chitosan for Pharmaceutical Applications

2021

View full text Add to dashboard Cite

Nine crosslinked chitosan derivatives (CLCS) were prepared using three different types of crosslinkers: glutaraldehyde, glyoxal and terephthaldehyde. The prepared CLCS were used to control the acyclovir (ACV) release in order to improve its oral bioavailability. The CLCS were prepared by Schiff based reaction and characterized by means of infrared spectroscopy (FTIR), x-ray diffraction measurements, thermogravimetric inspection, differential scanning calorimetry, and scanning electron microscopy (SEM). Establishment of an imine (C=N) bond was evidenced in FTIR. Compared to raw chitosan, the crosslinked chitosan derivatives showed more amorphous structure and exhibited more water holding capacity that increased with raising the crosslinking percent. In SEM, the CLCS demonstrated areas with rough surfaces and grooves that did not present in the smooth chitosan surface. The difference in swelling degree with varying crosslinker amount was also examined. The crosslinked chitosan displayed less swelling, and the degree of swelling decreased with increasing the density of crosslinking agent. The CLCS investigated in controlling the release of acyclovir by being incorporated with ACV in granules formulations. In vitro drug release results exhibited sustained release of ACV affected by the type and percent of crosslinker.

show abstract

Impact of acid type and glutaraldehyde crosslinking in the physicochemical and mechanical properties and biodegradability of chitosan films

Cited by 57 publications

References 49 publications

A Slot-Die Technique for the Preparation of Continuous, High-Area, Chitosan-Based Thin Films

A Slot-Die Technique for the Preparation of Continuous, High-Area, Chitosan-Based Thin Films

Examining the Impact of Squaric Acid as a Crosslinking Agent on the Properties of Chitosan-Based Films

Chemical Modification and Characterization of Chitosan for Pharmaceutical Applications

Contact Info

Product

Resources

About