Impact of accelerator-based boron neutron capture therapy (AB-BNCT) on the treatment of multiple liver tumors and malignant pleural mesothelioma

l-Boronophenylalanine-Mediated Boron Neutron Capture Therapy for Malignant Glioma Progressing After External Beam Radiation Therapy: A Phase I Study

“…Experimental approaches to improve efficacy of BNCT in the treatment of brain tumors include administration of BNCT in combination with conventional radiation therapy or targeted systemic therapies, and use of novel boron carrier compounds and boron delivery methods such as convection-enhanced delivery (29)(30)(31)(32)(33). Proton accelerator-based neutron irradiation facilities, compatible with installment in hospital environments, are being developed and may eventually allow a more widespread use of the technique (34).…”

External and internal radiation therapy: Past and future directions

“…[30,31] INTERNAL RADIATION THERAPY Boron neutron capture therapy Boron neutron capture therapy (BNCT) offers a means of treating individual tumor cells (e.g. multiple pleural tumors [32] multiple liver tumors, [33,34] spinal tumors, [35] glioblastomas and extracranial tumors, [36] head and neck malignancies [37] and oral cancer [38,39] ), possibly cells unconnected with a main tumor mass. It is based on the nuclear reaction ( 10 B + n th → [ 11 B*] → α + 7 Li + 2.79 MeV) that alpha and lithium particles have high LET and high RBE.…”

“…The Be(p,n) reaction at low proton energy is widely accepted as the best promising for epi-thermal neutron generation. [34] Shortening of irradiation time makes it possible to finish irradiation while maintaining a high 10 B concentration in the tumor, and to reduce the non-selective background dose. [34] In addition, shortening of irradiation time provides comfort to the patients during irradiation and single or two-fractionated BNCT has economic benefits.…”

“…[34] Shortening of irradiation time makes it possible to finish irradiation while maintaining a high 10 B concentration in the tumor, and to reduce the non-selective background dose. [34] In addition, shortening of irradiation time provides comfort to the patients during irradiation and single or two-fractionated BNCT has economic benefits. Another important feature of the AB-BNCT system is its capability of delivering greater doses to deep-seated tumors than RB-BNCT (reactor-based BNCT).…”

“…Another important feature of the AB-BNCT system is its capability of delivering greater doses to deep-seated tumors than RB-BNCT (reactor-based BNCT). [34,39] …”