Impact des médicaments sur l’environnement : état des lieux, évaluation des risques, communication

Defarges, Thierry Moreau; Guerbet, Michel; Massol, Jacques

doi:10.2515/therapie/2011040

Cited by 4 publications

(3 citation statements)

References 8 publications

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“…En effet, le rejet en continu de médicaments et de leurs métabolites dans le milieu aquatique confère à ces molécules un caractère de pseudo-persistance. Leur présence dans le milieu aquatique dépend d'un certain nombre de facteurs, comme leur faible dégradation, leur liposolubilité élevée, leur stabilité ou encore leur demi-vie (Defarges et al, 2011 ;Zuccato et Castiglioni, 2011).…”

Section: Discussionunclassified

Présence de métaux lourds et de résidus médicamenteux dans les effluents des établissements de santé de Dakar (Sénégal)

Touré¹,

Garat²,

Diop³

et al. 2016

Int. J. Bio. Chem. Sci

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Section: Discussionunclassified

Présence de métaux lourds et de résidus médicamenteux dans les effluents des établissements de santé de Dakar (Sénégal)

Touré¹,

Garat²,

Diop³

et al. 2016

Int. J. Bio. Chem. Sci

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“…In the last few decades, increasing attention has been paid to pharmaceutical industries that generate liquid wastes containing several pollutants and toxic substances [ 1 – 4 ]. These pollutants induce undesirable effects on the ecosystem and can potentially cause unexpected consequences and unintended effects on living organisms [ 5 – 8 ]. Consequently, treating these wastes becomes a major environmental issue for modern pharmaceutical industries and scientific research institutions.…”

Section: Introductionmentioning

confidence: 99%

Kinetic control concept for the diffusion processes of paracetamol active molecules across affinity polymer membranes from acidic solutions

Tarhouchi¹,

Louafy²,

Atmani³

et al. 2022

BMC Chemistry

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Background Paracetamol compound remains the most used pharmaceutical as an analgesic and antipyretic for pain and fever, often identified in aquatic environments. The elimination of this compound from wastewater is one of the critical operations carried out by advanced industries. Our work objective was to assess studies based on membrane processes by using two membranes, polymer inclusion membrane and grafted polymer membrane containing gluconic acid as an extractive agent for extracting and recovering paracetamol compound from aqueous solutions. Result The elaborated membrane characterizations were assessed using Fourier-transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). Kinetic and thermodynamic models have been applied to determine the values of macroscopic (P and J0), microscopic (D* and Kass), activation and thermodynamic parameters (Ea, ΔH#, ΔS#, ΔH#diss, and ΔH#th). All results showed that the PVA–GA was more performant than its counterpart GPM–GA, with apparent diffusion coefficient values (107D*) of 41.807 and 31.211 cm2 s−1 respectively, at T = 308 K. In addition, the extraction process for these membranes was more efficient at pH = 1. The relatively low values of activation energy (Ea), activation association enthalpy (ΔH≠ass), and activation dissociation enthalpy (ΔH≠diss) have indicated a kinetic control for the oriented processes studied across the adopted membranes much more than the energetic counterpart. Conclusion The results presented for the quantification of oriented membrane process ensured clean, sustainable, and environmentally friendly methods for the extraction and recovery of paracetamol molecule as a high-value substance.

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“…In the last few decades, increasing attention has been paid to pharmaceutical industries that generate liquid wastes containing several pollutants and toxic substances [1][2][3][4][5]. These pollutants induce undesirable effects on the ecosystem and can potentially cause unexpected consequences and unintended effects on living organisms [5][6][7][8][9]. Consequently, the treatment of these wastes becomes a major environmental issue for modern pharmaceutical industries and scientific research institutions.…”

Section: Introductionmentioning

confidence: 99%

Kinetic Control Concept for the Diffusion Processes of Paracetamol Active Molecules Across Affinity Polymer Membranes

Tarhouchi¹,

Louafy²,

Atmani³

et al. 2021

Preprint

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Background: Paracetamol compound remains the most used pharmaceutical as an analgesic and antipyretic for pain and fever. It has been detected in aquatic environments. The recovery of this compound from wastewater is one of the important operations carried out by modern industries. Its recovery is especially important for environmental protection. Currently, research is focused on membrane technology that has gained considerable interest over the last decades due to the various advantages that it presents.Result: Our work reports the selective extraction of paracetamol from liquid solution using two types of affinity polymer membranes: (i) polymer inclusion membrane (PIM) and (ii) grafted polymer membrane (GPM). The same extractive agent, gluconic acid (GA), is used for both. After total characterization, the developed membranes were adopted. Kinetic and thermodynamic models have been used to determine the values of various macroscopic parameters, permeability (P), and initial flux (J0), to understand the membrane performance. The same techniques have been used to determine the values of different microscopic parameters, association constant (Kass), and apparent diffusion coefficient (D*) that determine the interaction between the paracetamol substrates and the extractive agent, necessary for the diffusion of paracetamol molecules through the membrane. Similarly, the effects of initial concentration (C0), acidity (pH), and temperature were examined.Conclusion: The experimental results allow the determination of values of activation and thermodynamic parameters (Ea, ΔH#, ΔS#, ΔH#dis, and ΔH#th). The results explain the membrane performances and confirm that the energetic or kinetic aspects control the mechanisms related to the oriented processes. The results also indicate that it is possible to recycle wastewater and eliminate contaminants such as paracetamol.

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Impact des médicaments sur l’environnement : état des lieux, évaluation des risques, communication

Cited by 4 publications

References 8 publications

Présence de métaux lourds et de résidus médicamenteux dans les effluents des établissements de santé de Dakar (Sénégal)

Présence de métaux lourds et de résidus médicamenteux dans les effluents des établissements de santé de Dakar (Sénégal)

Kinetic control concept for the diffusion processes of paracetamol active molecules across affinity polymer membranes from acidic solutions

Kinetic Control Concept for the Diffusion Processes of Paracetamol Active Molecules Across Affinity Polymer Membranes

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