Impact des facteurs individuels et environnementaux sur le taux d’aberrations chromosomiques de type translocations Partie 1 : âge, sexe, tabac, alcool

Grégoire, Éric; Gruel, Gaëtan; Martin, Chantal; Roch-Lefèvre, Sandrine; Vaurijoux, Aurélie; Voisin, Philippe; Roy, L.

doi:10.1051/radiopro/2009034

Cited by 5 publications

(3 citation statements)

References 30 publications

(62 reference statements)

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“…The frequency of chromosomal breaks remained low and constant (Fig. 1), with an initial average of approximately 4 breaks for 1,000 metaphases, corresponding to previously reported background frequency [13,16,17].…”

Section: No Chromosomal Change After a Single Mri Scansupporting

confidence: 72%

The effects of repeated brain MRI on chromosomal damage

et al. 2022

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Background Magnetic resonance imaging (MRI) is currently considered a safe imaging technique because, unlike computed tomography, MRI does not expose patients to ionising radiation. However, conflicting literature reports possible genotoxic effects of MRI. We herein examine the chromosomal effects of repeated MRI scans by performing a longitudinal follow-up of chromosomal integrity in volunteers. Methods This ethically approved study was performed on 13 healthy volunteers (mean age 33 years) exposed to up to 26 3-T MRI sessions. The characterisation of chromosome damage in peripheral blood lymphocytes was performed using the gold-standard biodosimetry technique augmented with telomere and centromere staining. Results Cytogenetic analysis showed no detectable effect after a single MRI scan. However, repeated MRI sessions (from 10 to 20 scans) were associated with a small but significant increase in chromosomal breaks with the accumulation of cells with chromosomal terminal deletions with a coefficient of 9.5% (95% confidence interval 6.5–12.5%) per MRI (p < 0.001). Additional exposure did not result in any further increase. This plateauing of damage suggests lymphocyte turnover. Additionally, there was no significant induction of dicentric chromosomes, in contrast to what is observed following exposure to ionising radiation. Conclusions Our study showed that MRI can affect chromosomal integrity. However, the amount of damage per cell might be so low that no chromosomal rearrangement by fusion of two deoxyribonucleic breaks is induced, unlike that seen after exposure to computed tomography. This study confirms that MRI is a safe imaging technique.

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Section: No Chromosomal Change After a Single Mri Scansupporting

confidence: 72%

The effects of repeated brain MRI on chromosomal damage

et al. 2022

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“…La technique de référence basée sur le dénombrement des aberrations instables (dicentriques, anneaux centriques et fragments acentriques) peut être appliquée lors d'un accident radiologique de moins de 6 mois (Grégoire et al, 2010). Cette limite est due au caractère instable des aberrations analysées.…”

Section: éTat De L'art De La Dosimétrie Biologiqueunclassified

Dosimétrie biologique en cas d’exposition radiologique d’un grand nombre d’individus : apport de la détection automatique des dicentriques

et al. 2010

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RÉSUMÉFollowing large-scale accidental overexposure to ionising radiation, a rapid triage of the exposed population can be performed by scoring dicentrics and ring chromosomes in 50 metaphases. This is rapid but not accurate. Following this triage step, the dose can be estimated by scoring 500 metaphases. This is lengthy but very accurate. To improve the methodology, we propose using software for automatic dicentric scoring, which was tested on 63 victims of a radiological accident. The method using automatic dicentric scoring was compared with the standard methods of manual scoring. The comparison of the doses obtained shows that the automatic method could replace the two steps of the manual scoring (50 and 500 metaphases). In fact, the automatic scoring method is more accurate than the manual scoring of 50 metaphases and can therefore be used for triage.

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“…Furthermore, translocations persist for many years in circulating lymphocytes and their frequency increases significantly with age and the lifetime conditions (alcohol, tobacco, pesticide exposure…) , (Sigurdson, 2008), (Grégoire, 2010). This increase has to be taken into consideration in evaluation of exposure and corrected for as a function of the age of the individual.…”

Section: Past Exposure To Ionizing Radiationmentioning

confidence: 99%