Impact and management of Campylobacter in human medicine - US perspective

Pasternack, Mark S.

doi:10.1016/s1201-9712(02)90182-7

Cited by 6 publications

(4 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, due to under-reporting, it is believed that the true number of cases is around eight times this [2], suggesting humans are infected on average at least once during their lifetime. Symptoms of campylobacteriosis include fever, abdominal cramp, and bloody diarrhoea, which can last for approximately seven days after infection, with one in a 1000 cases leading to the more serious neurological disease, Guillain-Barré syndrome [3]. …”

Section: Introductionmentioning

confidence: 99%

Does age acquired immunity confer selective protection to common serotypes of Campylobacter jejuni?

et al. 2005

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Does age acquired immunity confer selective protection to common serotypes of Campylobacter jejuni?

et al. 2005

View full text Add to dashboard Cite

show abstract

“…In both Europe and the United States, the drug of choice for treatment-once the diagnosis has been established-is a macrolide (e.g., erythromycin) [2][3][4]. This often poses a therapeutic dilemma, because erythromycin appears to be effective only if it is given early in the course of illness [6].…”

mentioning

confidence: 99%

Short‐Term and Medium‐Term Clinical Outcomes of Quinolone‐ResistantCampylobacterInfection

et al. 2009

View full text Add to dashboard Cite

show abstract

“…This information was not available for Campylobacter. Duplicates were removed if multiple isolates belonging to the same serovar (Salmonella) and species (Campylobacter) were obtained from the same patient within six months for Salmonella (Mughini-Gras et al, 2020) and two months for Campylobacter (Brachman & Evans, 1998;Pasternack, 2002). This resulted in a cleaned database for both Salmonella and Campylobacter.…”

Section: Case Datamentioning

confidence: 99%

“…A chronic infection was defined when multiple isolates belonging to the same Campylobacter species were obtained from the same patient within two months. (Brachman & Evans, 1998;Pasternack, 2002)…”

Section: Text S4mentioning

confidence: 99%

"Everything comes from somewhere"

Mulder¹

View full text Add to dashboard Cite

The emergence and spread of infectious diseases, especially zoonoses, is complex and depends on various determinants or drivers, including their interrelations at the human-animal-environment interface (HAEI). This thesis provides novel insights into the potential role of environmental transmission in the epidemiology of selected exemplary zoonotic pathogens (i.e. Campylobacter, Shiga toxin-producing E. coli O157, and non-typhoid Salmonella) that are typically considered as foodborne pathogens. This was done mainly by studying some of their characteristics in the environment and the spatial associations between their incidence among human cases and the level of exposure to local livestock density, using novel methods within an eco-epidemiological framework. In addition, this thesis explored the potential human health effects linked to extreme rainfall events and the spatial association between the urban-rural gradient and the diversity and composition of the human gut microbiome. Chapter 2 showed that direct exposure to pluvial floodwater, and activities leading to such exposure, are associated with an increased risk of developing acute gastroenteritis (AGE) and acute respiratory infection (ARI). Chapter 3 showed that surface water is mainly contaminated with Campylobacter originating from meat-producing poultry (i.e. broilers and turkeys) in areas with high poultry densities and from wild birds in recreational waters and WWTP discharge points. The results of Chapter 4 and 5 revealed that human STEC O157 infections can be caused by environmental exposure to small ruminants besides food, while the route of transmission of Salmonella and Campylobacter to humans is mainly foodborne. Chapter 6 revealed that bacterial diversity, richness and composition of the adult gut microbiome are associated with the urban-rural gradient in the Netherlands. This thesis showed that we cannot ignore the role of the environment in mediating the transmission of (foodborne) zoonotic pathogens from livestock and wildlife, and more holistically in shaping the human gut microbiome. However, evidence about specific routes of transmission (e.g. air-borne, via soil or water) and their relative importance, was not provided. To study all interactions between different drivers of zoonotic pathogens, we recommend future studies to focus on pathogen transmission and their related transmission pathways to be able to look beyond the three drivers of change included in the One Health disease triangle (humans, animals, environment). This can be visualized by including a white triangle based on the Gestalt idea that the sum of visual perception is more than its parts. This triangle illustrates the interactions to include to study zoonotic pathogens and provide a complete picture of how they may influence one another. This visualization can be considered as a first step towards further unraveling the complexity of zoonotic pathogens by showing “the complete picture” or at least an attempt to do so, to, in the end, achieve optimal health outcomes.

show abstract

Impact and management of Campylobacter in human medicine - US perspective

Cited by 6 publications

References 33 publications

Does age acquired immunity confer selective protection to common serotypes of Campylobacter jejuni?

Does age acquired immunity confer selective protection to common serotypes of Campylobacter jejuni?

Short‐Term and Medium‐Term Clinical Outcomes of Quinolone‐ResistantCampylobacterInfection

"Everything comes from somewhere"

Contact Info

Product

Resources

About