Impact and characteristics of quality of life in Japanese patients with multiple sclerosis

Kikuchi, Hiromi; Mifune, Nobuhiro; Niino, Masaaki; Ohbu, Sadayoshi; Kira, Jun Ichi; Kohriyama, Tatsuo; Ota, Kohei; Tanaka, Masami; Ochi, Hirofumi; Nakane, Shunya; Maezawa, Masaji; Kikuchi, Seiji

doi:10.1007/s11136-010-9725-2

Cited by 27 publications

(30 citation statements)

References 45 publications

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“…In fact, declining performance over time in tests for attention and verbal memory are predictive of impaired employment status, 13 which is important for maintaining patient quality of life (QOL). 14 The associations of MRI findings and social activities with cognitive function can vary among different ethnicities or countries, because cognitive impairment evaluated using BRB-N is influenced by several variables, such as age, sex and level of education. 15,16 In the present study, we aimed to evaluate the associations of MRI findings and working status with cognitive function in Japanese patients with MS.…”

Section: Introductionmentioning

confidence: 99%

Association of cognitive impairment with magnetic resonance imaging findings and social activities in patients with multiple sclerosis

Niino

Mifune

Kohriyama³

et al. 2014

Clinical & Exp Neuroim

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Objective The aim of the present study was to investigate the association of magnetic resonance imaging (MRI) findings and social activity with cognitive function in Japanese patients with multiple sclerosis (MS). Methods The Brief Repeatable Battery of Neuropsychological tests (BRB-N) was carried out in 184 Japanese patients with MS, and 163 controls matched for age, sex and education. MRI findings of cerebral, brainstem, and cerebellar lesions and social activities of MS patients were further examined. Results MS patients with higher numbers of cerebral lesions on MRI had lower scores in most BRB-N tests. BRB-N scores in the majority of tests were significantly lower in patients with brainstem and cerebellar lesions. Data from an analysis of variance model in which only the main effects of cerebral, brainstem and cerebellar lesions were hypothesized showed an association of cerebral lesions with decreased scores in all BRB-N tests, except symbol digit modalities test (SDMT) and paced auditory serial addition test (PASAT). In contrast, cerebellar lesions were associated with decreased SDMT and PASAT scores. Patients categorized as "unemployed because of MS" had lower BRB-N scores than other social activity groups. Lower SDMT scores had an effect on the "unemployed because of MS" group, whereas the Expanded Disability Status Scale had a significantly greater negative impact on patients in this social category. Conclusions Higher numbers of brain lesions on MRI could have an impact on cognitive function in patients with MS, and impairment of information processing appears significantly associated with cerebellar lesions. Cognitive impairment affects the employment status of patients with MS.

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Section: Introductionmentioning

confidence: 99%

Association of cognitive impairment with magnetic resonance imaging findings and social activities in patients with multiple sclerosis

Niino

Mifune

Kohriyama³

et al. 2014

Clinical & Exp Neuroim

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“…The results highlighted that participants did not display any significant change in self-reported health-related quality-of-life during the initial 3-month transition period. Although health-related quality-of-life has been identified in the literature as a difficult domain to both measure and interpret given the subjective nature of the construct [32,33], the EQ-5D has been identified as a valid and reliable instrument when utilised in studies of individuals experiencing numerous health concerns [32][33][34]. Of importance to note in this study was that scores did not significantly improve between pre-discharge and post-discharge ratings for participants with ABI.…”

Section: Discussionmentioning

confidence: 77%

Profiling early outcomes during the transition from hospital to home after brain injury

et al. 2009

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“…This confirms that while MS has low incidence compared to other neurological disorders, it can bring about a huge burden as it occurs at an early age. In the case of Japan whose epidemiological characteristics have the greatest similarity to those of Korea, its incidence is slightly higher than Korea's, but its prevalence is on the steady rise [12,33]. Given that Korea's domestic circumstances are similar, one can anticipate that MS will take up a higher portion of the entire burden of disease.…”

Section: Discussionmentioning

confidence: 99%

“…Adjusted prevalence of MS in the United Kingdom (average latitude is 54.6 N) is 21 per 100,000, but 4 per 100,000 in northern Latin America (average latitude of 20.7 S) [2,9,10]. In Korea, Kim et al [11] reported 3.5 per 100,000 through national survey in 2006, which is one of the lowest in the world, even compared to that of the 3.9 in 100,000 in Morioka, Japan, located at the similar latitude in the neighboring country [12,13]. …”

Section: Introductionmentioning

confidence: 99%

Burden of Disease of Multiple Sclerosis in Korea

et al. 2012

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OBJECTIVESMultiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system. There are few reports on the burden of disease of MS, worldwide. The authors aim to estimate burden of disease and estimate the epidemiologic indexes of MS in Korea using available epidemiologic data.METHODSEpidemiologic indexes were computed using DISMOD II software based on prevalence from nationwide survey, incidence estimated from extrapolation, mortality from National Statistics Office, and duration of disease from literature as input indexes. We calculated disability-adjusted life year (DALY) as a measure of premature mortality and disability, equivalent to years of healthy life lost due to a given condition.RESULTSThe incidence of MS in Korea was 0.1 per 100,000, higher in female than in male. The highest incidence was estimated in the age group between 35 and 44 years in male and age group between 25 and 29 years in female. Total burden of disease of MS was 1,394 DALY, comprised of 292 (21%) years of life lost and 1,101 (79%) years lived with disability. The mean age at onset of MS was 33 years old in men and 32 years old in female. Estimated duration of disease was 35 years in men and 40 years in female. Most of the DALY of MS occurred in the adult population between 25 and 54 years of age.CONCLUSIONAlthough MS is a rare disease in Korea, most of the DALY arises from young people, which results in a major financial burden on the patient, family, health system and society.

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Impact and characteristics of quality of life in Japanese patients with multiple sclerosis

Abstract: Support for finding employment and having increased or maintained household income and readily available information about the disease contribute to improving QOL in Japanese MS patients.

Cited by 27 publications

References 45 publications

Association of cognitive impairment with magnetic resonance imaging findings and social activities in patients with multiple sclerosis

Association of cognitive impairment with magnetic resonance imaging findings and social activities in patients with multiple sclerosis

Profiling early outcomes during the transition from hospital to home after brain injury

Burden of Disease of Multiple Sclerosis in Korea

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