Burden of Disease of Multiple Sclerosis in Korea

Abstract

OBJECTIVESMultiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system. There are few reports on the burden of disease of MS, worldwide. The authors aim to estimate burden of disease and estimate the epidemiologic indexes of MS in Korea using available epidemiologic data.METHODSEpidemiologic indexes were computed using DISMOD II software based on prevalence from nationwide survey, incidence estimated from extrapolation, mortality from National Statistics Office, and duration of disease from literature as input indexes. We calculated disability-adjusted life year (DALY) as a measure of premature mortality and disability, equivalent to years of healthy life lost due to a given condition.RESULTSThe incidence of MS in Korea was 0.1 per 100,000, higher in female than in male. The highest incidence was estimated in the age group between 35 and 44 years in male and age group between 25 and 29 years in female. Total burden of disease of MS was 1,394 DALY, comprised of 292 (21%) years of life lost and 1,101 (79%) years lived with disability. The mean age at onset of MS was 33 years old in men and 32 years old in female. Estimated duration of disease was 35 years in men and 40 years in female. Most of the DALY of MS occurred in the adult population between 25 and 54 years of age.CONCLUSIONAlthough MS is a rare disease in Korea, most of the DALY arises from young people, which results in a major financial burden on the patient, family, health system and society.

Optic Neuritis in Korean Children: Low Risk of Subsequent Multiple Sclerosis

“…6,7,[16][17][18][19][20] The incidence of multiple sclerosis in Korea is 0.1 per 100,0000. 11 The association of multiple sclerosis and adult optic neuritis in Korea is not known. Because the incidence of multiple sclerosis in Korea is low, the conversion rate of optic neuritis to multiple sclerosis is presumed to be low and studies on the conversion rate of optic neuritis to multiple sclerosis in Korea are rare.…”

“…7 The clinical characteristics of optic neuritis and multiple sclerosis have been reported to vary by race. Multiple sclerosis is rare in Korea, Japan, and China, 11,12 and the prognosis for optic neuritis in these countries is quite different from that in Europe or North America.…”

Modeling the Burden of Abdominal Aortic Aneurysm in the USA in 2013

“…This has previously been used to model the burden of a wide range of other diseases, such as diabetes [14,15], multiple sclerosis [16], schizophrenia [17], and malaria [18]. The mathematical model of DisMod II is a multistate life table describing a single disease, where transition hazards define the relationships between three states: healthy, diseased, and dead [19] (fig.…”

Carga de doença no Brasil e suas regiões, 2008

“…Initially used to estimate burden of disease in major world regions 13 , DALY has been employed to estimate burden of disease of countries 14,17,18 , regions of countries 19 , and cities 20 , and even to evaluate the burden of specific diseases 21 . In addition, since DALY is quite sensitive for measuring health inequalities, it can also be used to identify the population's most vulnerable groups 22 .…”