Immunotropic Properties of an Experimental Synthetic Selenium-Organic Compound

Yur'eva, O V; Дубровина, В. И.; Потапов, В. А.; Мусалов, М. В.; Старовойтова, Т. П.; Иванова, Т. А.; Шкаруба, Т. Т.; Yakimov, V. A.; Балахонов, С. В.

doi:10.1007/s10517-020-04819-4

Cited by 8 publications

(3 citation statements)

References 6 publications

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“…In addition, significant leukocytopenia was noted by 1 and 3 days after irradiation, while in animals irradiated without selenium subsidies, moderate leukocytosis was recorded by 1 st day, followed by a slight decrease in the absolute number of leukocytes by 3rd day. The described clinical manifestations against the background of increased doses of selenium are consistent with those described in the literature and obtained by us in preclinical studies [7,8].…”

Section: Discussionsupporting

confidence: 88%

Peculiarities of the course of acute radiation injury in mice against the background of iodine and selenium preparations

et al. 2022

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In experiments on mice the study of the radioprotective and radiotherapeutic efficacy of the combined use of the selenium-containing feed additive DAFS-25k and the iodine-containing preparation Monclavit-1 was carried out. It has been shown that intragastric administration of DAFS-25k oil solution 3 hours before the total, external, single exposure to γ-radiation, and the subsequent (in 12 hours) intragastric administration of an aqueous solution of Monclavit-1, increases the survival rate of irradiated animals to 67% versus 17% in the control animals. The mechanisms of radioprotective efficacy are assumed to be the antioxidant activity of selenium compounds in DAFS-25k, normalization of thyroid function and relief of gastrointestinal syndrome due to the pronounced antimicrobial activity of Monclavit-1.

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Section: Discussionsupporting

confidence: 88%

Peculiarities of the course of acute radiation injury in mice against the background of iodine and selenium preparations

et al. 2022

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“… 9 10 11 12 13 14 NO promotes wound cleaning through the formation of peroxynitrite, deamination of DNA and S-nitrosirovanietiols on the surface of cell membranes, oxidative damage to DNA and lipid peroxidation. 15 16 17 18 19 During the proliferation phase of wound healing, NO increases angiogenesis, and accelerates fibroblast proliferation, maturation and fibrotic transformation of granulation tissue. 15 20 21 22 23 …”

Section: Introductionmentioning

confidence: 99%

Nitric oxide therapy is beneficial to rehabilitation in professional soccer players: clinical and experimental studies

et al. 2023

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Nitric oxide can activate neutrophils and macrophages, facilitate the synthesis of collagen, which allows significantly accelerating the regeneration of traumatized tissues. We studied the effects of nitric oxide-containing gas flow generated by plasma-chemical device “Plason” in a rat model of full-thickness wounds. Histological and morphometric analyses revealed that Plason treated wounds expressed significantly fewer signs of inflammation and contained a more mature granulation tissue on day 4 after the operation. Considering the results of the experimental study, we applied the Plason device in sports medicine for the treatment of lower limb bruises of 34 professional soccer players. Athletes were asked to assess the intensity of pain with the Visual Analogue Scale. Girths of their lower limbs were measured over the course of rehabilitation. Nitric oxide therapy of full-thickness wounds inhibited inflammation and accelerated the regeneration of skin and muscle tissues. Compared with the control, we observed a significant reduction in pain syndrome on days 2–7 after injuries, edema, and hematoma, and shortened treatment duration. This pilot study indicates that the use of nitric oxide is a promising treatment method for sports injuries.

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“…Earlier, we studied the properties of a new experimental synthetic organoselenium compound 2,6-dipyridinium-9-selenabicyclo[3.3.1]nonane dibromide (974zh) obtained in the Laboratory of Organochalcogen Compounds of A. E. Favorsky Irkutsk Institute of Chemistry. It was found that 974zh suppresses the development of pathological reactions in the organism of experimental animals vaccinated with live tularemia and brucellosis vaccines [5]. It also decreases the cAMP/cGMP ratio in the thymus and spleen of experimental mice, which indirectly reflects proliferative activity of cells of immunocompetent organs.…”

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confidence: 99%

Effect of a Synthetic Organoselenium Compound on Post-Vaccination Immunopoiesis in the Red Bone Marrow and Cell Composition of Peripheral Blood of White Mice Vaccinated with Yersinia pestis EV

et al. 2021

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We studied the effect of an experimental synthetic organoselenium compound 2,6-dipyridinium-9-selenabicyclo[3.3.1]nonane dibromide (974zh) on the cell composition of the red bone marrow and peripheral blood in white mice. The study drug co-administered with Yersinia pestis EV vaccine strain (10 3 CFU) potentiated maturation and migration of mature neutrophils from the bone marrow into the circulation. Reducing the dose of the live vaccine and the anti-inflammatory properties of the study drug made it possible to reduce the allergic reaction during the vaccination process.

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Immunotropic Properties of an Experimental Synthetic Selenium-Organic Compound

Cited by 8 publications

References 6 publications

Peculiarities of the course of acute radiation injury in mice against the background of iodine and selenium preparations

Peculiarities of the course of acute radiation injury in mice against the background of iodine and selenium preparations

Nitric oxide therapy is beneficial to rehabilitation in professional soccer players: clinical and experimental studies

Effect of a Synthetic Organoselenium Compound on Post-Vaccination Immunopoiesis in the Red Bone Marrow and Cell Composition of Peripheral Blood of White Mice Vaccinated with Yersinia pestis EV

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