Peculiarities of the course of acute radiation injury in mice against the background of iodine and selenium preparations

Abstract

In experiments on mice the study of the radioprotective and radiotherapeutic efficacy of the combined use of the selenium-containing feed additive DAFS-25k and the iodine-containing preparation Monclavit-1 was carried out. It has been shown that intragastric administration of DAFS-25k oil solution 3 hours before the total, external, single exposure to γ-radiation, and the subsequent (in 12 hours) intragastric administration of an aqueous solution of Monclavit-1, increases the survival rate of irradiated animals to 67% versus 17% in the control animals. The mechanisms of radioprotective efficacy are assumed to be the antioxidant activity of selenium compounds in DAFS-25k, normalization of thyroid function and relief of gastrointestinal syndrome due to the pronounced antimicrobial activity of Monclavit-1.