Immunotoxicity of heavy metals in relation to Great Lakes.

Bernier, Jacques; Brousseau, Pauline; Krzystyniak, Krzysztof; Tryphonas, Helen; Fournier, Michel

doi:10.1289/ehp.95103s923

Cited by 78 publications

(27 citation statements)

References 110 publications

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“…Reviews recently have been published on immunotoxicity and the possible impacts of heavy metals (265), pesticides (266), and PCBs (267) in relation to human health and the Great Lakes.…”

Section: S=c\r-mentioning

confidence: 99%

Environmental Endocrine Disruption: An Effects Assessment and Analysis

Crisp¹,

Clegg²,

Cooper³

et al. 1998

Environmental Health Perspectives

165

145

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“…Reviews recently have been published on immunotoxicity and the possible impacts of heavy metals (265), pesticides (266), and PCBs (267) in relation to human health and the Great Lakes.…”

Section: S=c\r-mentioning

confidence: 99%

Environmental Endocrine Disruption: An Effects Assessment and Analysis

Crisp¹,

Clegg²,

Cooper³

et al. 1998

Environmental Health Perspectives

165

145

View full text Add to dashboard Cite

“…e changes in GST enzyme activity may be reduced in Pb-GSH conjugates and excretion, leading to accumulation of lead in blood. In turn, previous studies also reported that lead could in�uence on suppression of T-helper type 1 cells and enhancement of T helper type 2 ( 2) cells [27,28]. In addition, these 2 cells are signi�cantly related to IL-6 production which played a role in the upregulation of both CRP and �brinogen [29,30].…”

Section: Discussionmentioning

confidence: 88%

Association between inflammatory marker, environmental lead exposure and glutathione S-transferase gene

et al. 2013

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A number of studies suggested that lead is related to the induction of oxidative stress, and alteration of immune response. In addition, modifying these toxic effects varied partly by GST polymorphism. e objectives of this study were to assess the association between the lead-induced alteration in serum hs-CRP, with GSTM1, GSTT1, and GSTP1 Val105Ile genetic variations and the health consequence from environmental lead exposure. e 924 blood samples were analyzed for blood lead, CRP, and genotyping of three genes with real-time PCR. Means of blood lead and serum hs-CRP were 5.45 g/dL and 2.07 mg/L. Both CRP and systolic blood pressure levels were signi�cantly higher for individuals with blood lead in quartile 4 (6.48-24.63 g/dL) compared with those in quartile 1 (1.23-3.47 g/dL,). In particular, in men with blood lead >6.47 g/dL the adjusted odds ratio (OR) of CRP levels for individuals with GSTP1 variants allele, GSTM1 null, GSTT1 null, double-null GSTM1, and GSTT1 compared with wild-type allele was 1.46 (95% CI; 1.05-2.20), 1.32 (95% CI; 1.03-1.69), 1.65 (95% CI; 1.17-2.35), and 1.98 (95% CI; 1.47-2.55), respectively. Our �ndings suggested that lead exposure is associated with adverse changes in in�ammatory marker and SBP. GST polymorphisms are among the genetic determinants related to lead-induced in�ammatory response.

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“…Exposure to heavy metals in the environment has been related to immunotoxic effects and has been targeted for direct reduction in consumption (e.g. consuming less foods with trace amounts of metals) (134). Heavy metals present in PM appear to be the main culprits impacting mental health via the respiratory system, cardiovascular system and immune system (69,74,86).…”

Section: Discussionmentioning

confidence: 99%

Air pollution, aeroallergens and suicidality: a review of the effects of air pollution and aeroallergens on suicidal behavior and an exploration of possible mechanisms

Ragguett

Danielle

Subramaniapillai

et al. 2017

Reviews on Environmental Health

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Objective: Risk factors for suicide can be broadly categorized as sociodemographic, clinical and treatment. There is interest in environmental risk and protection factors for suicide. Emerging evidence suggests a link between environmental factors in the form of air pollution and aeroallergens in relation to suicidality. Methods: Herein, we conducted a systematic review of 15 articles which have met inclusion criteria on the aforementioned effects. Results: The majority of the reviewed articles reported an increased suicide risk alongside increased air pollutants or aeroallergens (i.e. pollen) increase; however, not all environmental factors were explored equally. In specific, studies that were delimited to evaluating particulate matter (PM) reported a consistent association with suicidality. We also provide a brief description of putative mechanisms (e.g. inflammation and neurotransmitter dysregulation) that may mediate the association between air pollution, aeroallergens and suicidality. Conclusion:Available evidence suggests that exposure to harmful air quality may be associated with suicidality. There are significant public health implications which are amplified in regions and countries with greater levels of air pollution and aeroallergens. In addition, those with atopic sensitivity may represent a specific subgroup that is at risk.

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Immunotoxicity of heavy metals in relation to Great Lakes.

Cited by 78 publications

References 110 publications

Environmental Endocrine Disruption: An Effects Assessment and Analysis

Environmental Endocrine Disruption: An Effects Assessment and Analysis

Association between inflammatory marker, environmental lead exposure and glutathione S-transferase gene

Air pollution, aeroallergens and suicidality: a review of the effects of air pollution and aeroallergens on suicidal behavior and an exploration of possible mechanisms

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