Environmental Endocrine Disruption: An Effects Assessment and Analysis

Crisp, Thomas M.; Clegg, Eric D.; Cooper, Ralph L.; Wood, William R.; Anderson, David G.; Baetcke, Karl P.; Hoffmann, Jennifer L.; Morrow, Melba S.; Rodier, Donald J.; Schaeffer, John E.; Touart, Leslie W.; Zeeman, Maurice; Patel, Yogendra M.

doi:10.2307/3433911

Cited by 157 publications

(149 citation statements)

References 145 publications

(172 reference statements)

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“…Recently, exogenous environmental pollutants exposure has gained more attention on their endocrinedisrupting effects and other human health impacts [1][2][3][4][5]. This concern was highlighted by a recent survey of 1,442 French male newborns perinatally exposed to environmental chemicals, revealing a potential link between pollutants biochemical effects and occurrence of diseases [6].…”

Section: Introductionmentioning

confidence: 96%

MAPK and NF-κB Pathways Are Involved in Bisphenol A-Induced TNF-α and IL-6 Production in BV2 Microglial Cells

et al. 2014

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Microglial activation has been reported to play an important role in neurodegenerative diseases by producing pro-inflammatory cytokines. Bisphenol A (BPA, 2,2-bis (4-hydroxyphenyl) propane), known as a ubiquitous endocrine-disrupting chemical, is reported to perform both mimic- and anti-estrogen properties; however, whether it affects cytokine production or immune response in central nervous system remains unclear. The present study was aimed to explore whether BPA was involved in inflammatory action and to investigate the potential mechanisms in microglial cells. BV2, the murine microglial cell line, was used in the present work as the cell model. BPA-associated morphologic changes, cytokine responses, and signaling events were examined using immunofluorescence analysis, real-time PCR, enzyme-linked immunosorbent assay, and western blot. Our results indicated that BPA increased BV2 cells activation and simultaneously elevated tumor necrosis factor-α and interleukin 6 expression, which could be partially reversed by estrogen receptor antagonist, ICI182780. In addition, the c-Jun N-terminal protein kinase (JNK) inhibitor (SP600125), rather than ERK1/2 blocker (PD98059), displayed anti-inflammatory properties on BPA-elicited cytokine responses. Moreover, the inflammatory transcription factor NF-κB was specifically activated by BPA as well. These results, taken together, suggested that BPA may have functional effects on the response of microglial cell activation via, in part, the estrogen receptor, JNK, ERK mitogen-activated protein kinase, and NF-κB signaling pathways with its subsequent influence on pro-inflammatory action.

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Section: Introductionmentioning

confidence: 96%

MAPK and NF-κB Pathways Are Involved in Bisphenol A-Induced TNF-α and IL-6 Production in BV2 Microglial Cells

et al. 2014

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“…The most frequently reported effects of EDCs on reproductive process were on sex determination, secondary sexual characters, oogenesis, spermatogenesis and the onset Speciation Analysis and Environment of sexual maturation. 54 The exposure to these compounds during the juvenile life is responsible for genital anomalies, infertility or sexual inversion. 55 -57 The histological observations showed that kidney, pancreas and intestinal cells had irregular cellular outlines.…”

Section: Discussionmentioning

confidence: 99%

Effects of sublethal levels of tributyltin chloride on a new toxicity test organism, Liza saliens (osteichthyes, mugilidae): a histological study

D'Agati

Mansueto

et al. 2006

Applied Organom Chemis

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The histopathological effects of 10 −7 and 10 −9 M tributyltin(IV)chloride,TBTCl, solutions on different Liza saliens organs have been studied by light microscope. The fish were sacrificed after 3-4 h incubation in 10 −7 M TBTCl solution or after 15 days incubation in 10 −9 M solution. The observed histopathological changes were dose-and time-dependent. The 10 −7 M TBTCl concentration resulted in major damage to the gill epithelium, indicating that TBTCl primarily interfered with the respiration, osmoregulation, acid balance and nitrogenous waste excretion processes. After incubation in 10 −9 M TBTCl solution the fish lived 20 or more days, but many of the organs were altered. Thymus atrophy, reduced spleen and altered head kidney were observed. These histological results indicated that TBTCl interfered with organ immunodefense and altered main metabolic pathways in Liza saliens. The presence of melano-macrophage centers, only in TBT-treated liver and spleen, can be considered a tool to facilitate, with other biomarkers, the detection of alterations by toxicants. Regarding the pancreas activity in 10 −7 M solutions, it has been noted that, in the exocrine cells, very few zymogen granules were still present and the Langerhans islets were more altered. In 10 −9 M solution the exocrine pancreatic cells had no granules and the islet cells presented degenerative alterations. In addition, TBTCl, which altered the pancreas and gonad morphology, could again be considered an endocrine disrupter even if biochemical data are still necessary. Finally, the Liza saliens juveniles could be considered an interesting biological model for experiments with contaminants, due to their ease of adaptation to experimental conditions and food chain position.

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“…The classical definition reported by the Environmental Protection Agency of the United States (EPA-USA) is "An endocrine disruptor is an exogenous substance that causes adverse health effects in an intact organism, or its progeny, secondary to changes in endocrine function" [2].…”

Section: Introductionmentioning

confidence: 99%

Adverse Effects of Bisphenol A Exposure on Glucose Metabolism Regulation

Menale¹,

Mita²,

Diano³

et al. 2015

TOBIOTJ

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Bisphenol A (BPA) is used as basic chemical compound in the production of polycarbonate food containers or epoxy resins coating metallic cans for food and beverages conservation. Its xenoestrogenic activity alters endocrine-metabolic pathways modulating glucose metabolism and increasing the risk of developing diabetes, insulin resistance, and obesity. Based on in vitro and in vivo experimental research, here we report some of the major BPA adverse effects on tissues that play a key role in the regulation on the whole body's metabolism. Evidences have shown that BPA is able to exert its endocrine disrupting action altering glucose metabolism and contributing to the onset of metabolic disorders, acting on liver functions and affecting insulin production by the pancreas. Exposure to BPA has been reported also to modulate glucose utilization in muscles, as well as to interfere with adipose tissue endocrine function. In addition, to peripheral tissues, recent studies have shown that BPA by acting in the Central Nervous System affects neuroendocrine regulation of glucose metabolism, promoting glucose metabolism dysfunction such as glucose intolerance and insulin resistance. Thus, exposure to BPA seems to be an important risk factor in the onset of obesity and metabolic syndrome.However, its mechanisms of action need to be further investigated to provide a major evaluation of risk assessment.

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Environmental Endocrine Disruption: An Effects Assessment and Analysis

Cited by 157 publications

References 145 publications

MAPK and NF-κB Pathways Are Involved in Bisphenol A-Induced TNF-α and IL-6 Production in BV2 Microglial Cells

MAPK and NF-κB Pathways Are Involved in Bisphenol A-Induced TNF-α and IL-6 Production in BV2 Microglial Cells

Effects of sublethal levels of tributyltin chloride on a new toxicity test organism, Liza saliens (osteichthyes, mugilidae): a histological study

Adverse Effects of Bisphenol A Exposure on Glucose Metabolism Regulation

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